"Micromegaly": an update on the prevalence of acromegaly with apparently normal GH secretion in the modern era.

abstract：:Leptin is a key mediator in the maintenance of neuroendocrine homeostasis. The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia. The study consists of 16 consecutive patients with ...

journal_title：Pituitary

authors： Balci H,Akgun-Dar K,Gazioglu N,Kapucu A,Bolayirli M,Oz B

更新日期：2009-01-01 00:00:00

abstract：CONTEXT:Outcome of acromegaly surgery is assessed by IGF-1 and glucose-suppressed GH, but whether the latter provides additional clinically relevant information when IGF-1 is normal is unclear. The role of GH suppression testing after surgery requires clarification. METHODS:We studied 97 acromegaly patients with norma...

journal_title：Pituitary

authors： Freda PU,Bruce JN,Reyes-Vidal C,Singh S,DeLeon Y,Jin Z,Khandji AG,Cremers S,Post KD

更新日期：2020-10-30 00:00:00

abstract：:Resistance to dopamine agonists can be defined with respect to failure to normalize PRL levels and failure to decrease tumor size by > or = 50%. Using these definitions, failure to normalize PRL levels is seen in 24% of those treated with bromocriptine, 13% of those treated with pergolide and 11% of those treated with...

journal_title：Pituitary

authors： Molitch ME

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...

journal_title：Pituitary

authors： Hölsken A,Stache C,Schlaffer SM,Flitsch J,Fahlbusch R,Buchfelder M,Buslei R

更新日期：2014-12-01 00:00:00

abstract：:Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral prot...

journal_title：Pituitary

authors： Pérez FR,Camiña JP,Menéndez C,Beiras A,Casabiell X,Casanueva FF

更新日期：1998-04-01 00:00:00

abstract：:A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infi...

journal_title：Pituitary

authors： McIntyre EA,Perros P

更新日期：2007-01-01 00:00:00

abstract：:The diagnoses of acromegaly and dwarfism require biochemical confirmation of abnormal GH and IGF-1 concentrations. The same parameters are used for therapeutic decisions, i.e. initiation or termination of particular treatments. Therefore, reliable and epidemiologically and statistically proven criteria of normalcy for...

journal_title：Pituitary

authors： Barkan AL

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operat...

journal_title：Pituitary

authors： Ved R,Logier N,Leach P,Davies JS,Hayhurst C

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before. METHODS:In a retrospective electronic medical records review, 13 patients with SPA ...

journal_title：Pituitary

authors： Zhu J,Wang Z,Zhang Y,Liu J,Li X,Deng K,Lu L,Yao Y

更新日期：2020-08-01 00:00:00

abstract：:It is estimated that up to one in five individuals develops pituitary gland tumors, despite the common occurrence of these tumors, the pathogenetic mechanisms underlying their development mainly remain unknown. We studied the gene expression in null cell adenomas compared with normal pituitary by expressed sequence ta...

journal_title：Pituitary

authors： Hu J,Song H,Wang X,Shen Y,Chen F,Liu Y,Li S,Wang Y,Shou X,Zhang Y,Hu R

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Endogenous Cushing's syndrome (CS) is a rare disease that results from exposure to high levels of cortisol; Cushing's disease (CD) is the most frequent form of CS. Patients with CS suffer from a variety of comorbidities that increase the risk of mortality. Surgical resection of the disease-causing lesion is gen...

journal_title：Pituitary

authors： Fleseriu M,Castinetti F

更新日期：2016-12-01 00:00:00

abstract：:Glucocorticoids are important immunosuppressive hormones; these steroids also inhibit somatic growth by decreased growth hormone (GH) secretion and induced protein catabolism. The ability of ghrelin, the endogenous ligand for the GHS-1a receptor, to increase body weight is attributed to a combination of enhanced food ...

journal_title：Pituitary

authors： Tulipano G,Taylor JE,Halem HA,Datta R,Dong JZ,Culler MD,Bianchi I,Cocchi D,Giustina A

更新日期：2007-01-01 00:00:00

abstract：:Pituitary cysts are usually craniopharyngiomas or remnants of Rathke's cleft. Histologically craniopharyngiomas are lined by stratified squamous epithelium whereas Rathke's cleft cysts are lined by cuboidal or columnar epithelium. The management of pituitary cysts remains difficult because of the risks associated with...

journal_title：Pituitary

authors： Dashora U,Mathias D,James A,Zammit-Maempel I,Perros P

更新日期：2002-01-01 00:00:00

abstract：:Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...

journal_title：Pituitary

authors： Quintero Wolfe S,Hood B,Barker J,Benveniste RJ

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:In this study, we set out to define our institutional criteria for patient eligibility for transsphenoidal resection of parasellar meningiomas, and to report our experience with extended transnasal approaches for these lesions. We aimed to discuss the important considerations of patient selection and risk strat...

journal_title：Pituitary

authors： Castlen JP,Cote DJ,Zaidi HA,Laws ER Jr

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Cystic prolactinoma is a variant of prolactin-secreting pituitary adenoma. The strategies for the management of cystic prolactinoma have not been addressed thoroughly in clinical guidelines. METHODS:A literature search was performed using Pubmed to review the current approaches to the treatment of cystic ...

journal_title：Pituitary

authors： Nakhleh A,Shehadeh N,Hochberg I,Zloczower M,Zolotov S,Taher R,Daoud Naccache D

更新日期：2018-08-01 00:00:00

abstract：:The management of invasive giant prolactinomas (IGP) has been an area of some controversy. The relative roles of transsphenoidal surgery, craniotomy, radiation therapy and dopamine agonist based medical therapy are gradually becoming clarified. We report the results of management of 30 patients with IGP. Surgery was t...

journal_title：Pituitary

authors： Yu C,Wu Z,Gong J

更新日期：2005-01-01 00:00:00

abstract：:A high incidence of venous thromboembolic (VTE) complications has been reported in Cushing's syndrome (CS), mostly post-operatively and attributable to hypercoagulability. The prevalence of symptomatic VTE was investigated retrospectively in 58 consecutive CS patients in relation to acquired and genetic thrombotic ris...

journal_title：Pituitary

authors： Koutroumpi S,Daidone V,Sartori MT,Cattini MG,Albiger NM,Occhi G,Ferasin S,Frigo A,Mantero F,Casonato A,Scaroni C

更新日期：2013-06-01 00:00:00

abstract：CONTEXT:Somatostatin (SST) and dopamine (DA) inhibit growth hormone (GH) secretion and proliferation of GH-secreting pituitary adenomas (GHomas) through binding to SSTR2 and D2R receptors. Chimeric SST-DA compounds (Dopastatins) display increased potency in inhibiting GH secretion, as compared with individual SST or DA...

journal_title：Pituitary

authors： Cuny T,Graillon T,Defilles C,Datta R,Zhang S,Figarella-Branger D,Dufour H,Mougel G,Brue T,Landsman T,Halem HA,Culler MD,Barlier A,Saveanu A

更新日期：2021-01-12 00:00:00

abstract：PURPOSE:Nelson's syndrome is a challenging condition that can develop following bilateral adrenalectomy for Cushing's disease, with high circulating ACTH levels, pigmentation and an invasive pituitary tumor. There is no established medical therapy. The aim of the study was to assess the effects of pasireotide on plasma...

journal_title：Pituitary

authors： Daniel E,Debono M,Caunt S,Girio-Fragkoulakis C,Walters SJ,Akker SA,Grossman AB,Trainer PJ,Newell-Price J

更新日期：2018-06-01 00:00:00

abstract：:Most patients with acromegaly have some degree of insulin resistance. The principal mediator of insulin resistance in acromegaly is hypersecretion of growth hormone. Growth hormone acts at several levels to block insulin actions including inhibiting phosphorylation of the insulin receptor and one of its principal sign...

journal_title：Pituitary

authors： Clemmons DR

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Cushing's syndrome (CS) is a rare disease characterized by a collection of signs and symptoms, also common in the general population without elevated cortisol secretion. During the last years more patients with CS are identified earlier and with milder disease. Many of these patients are diagnosed during s...

journal_title：Pituitary

authors： Shimon I

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:To report the results of a consecutive series of patients who underwent an endoscopic endonasal approach (EEA) for resection of a pituitary adenoma and compare them to previous series of microscopic and endoscopic approaches. METHODS:A retrospective review of clinical and radiographic outcomes of a consecutive...

journal_title：Pituitary

authors： Paluzzi A,Fernandez-Miranda JC,Tonya Stefko S,Challinor S,Snyderman CH,Gardner PA

更新日期：2014-08-01 00:00:00

abstract：:Growth hormone excess has been associated with hypercalciuria and nephrolithiasis. Hypercalcemia in acromegaly is rare and usually due to coexistent primary hyperparathyroidism. To report two cases of 1,25-dihydroxyvitamin D (1,25 (OH)(2) D)-dependent hypercalcemia in cromegaly. A 50 year-old female with 2 years histo...

journal_title：Pituitary

authors： Shah R,Licata A,Oyesiku NM,Ioachimescu AG

更新日期：2012-12-01 00:00:00

abstract：:The diagnosis of disorders of growth hormone (GH) is dependent upon accurate measurement of insulin-like growth factor-I (IGF-I) concentrations since serum IGF-I assays have been found to be useful as a screening tests for the presence of growth hormone deficiency (GHD) in children and in both children and adults they...

journal_title：Pituitary

authors： Clemmons DR

更新日期：2007-01-01 00:00:00

abstract：:Nonfunctioning pituitary adenomas (NFPA) are typically benign neoplasms that can cause significant morbidity through local mass effects. MIB-1/Ki-67 and p53 immuno-reactivity are used to predict aggressive behavior but have known limitations. No marker to date is widely used to reliably predict tumor progression. Phos...

journal_title：Pituitary

authors： Hightower E,Cabanillas ME,Fuller GN,McCutcheon IE,Hess KR,Shah K,Waguespack SG,Corley LJ,Devin JK

更新日期：2012-12-01 00:00:00

abstract：:Familial neurohypophyseal diabetes insipidus (FNDI) is mostly an autosomal dominant inherited disorder presenting with severe polydipsia and polyuria typically in early childhood. To date, 69 different variations in the AVP gene encoding the AVP prohormone have been identified in autosomal dominant FNDI (adFNDI). In t...

journal_title：Pituitary

authors： Birkegaard C,Christensen JH,Falorni A,Marzotti S,Minarelli V,Gregersen N,Rittig S

更新日期：2013-06-01 00:00:00

abstract：:The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database) were studied before a...

journal_title：Pituitary

authors： Filipsson Nyström H,Feldt-Rasmussen U,Kourides I,Popovic V,Koltowska-Häggström M,Jonsson B,Johannsson G

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Lymphocytic hypophysitis (LH) is a rare chronic inflammatory disorder characterized by lymphocytic infiltration of the pituitary gland commonly affecting women during pregnancy or post-partum period. The pathogenesis remains uncertain, however an autoimmune process is frequently implicated. There is limited d...

journal_title：Pituitary

authors： Lim S,Elston MS,Swarbrick MJ,Conaglen JV

更新日期：2009-01-01 00:00:00

abstract：:Cushing's Syndrome (CS) is associated with an increased mortality, where hypercoagulability seems to have a crucial role in both arterial and venous thrombosis. Parameters of in vitro thrombin generation (TG) such as lag time, peak thrombin and endogenous thrombin potential (ETP), that describe the time until thrombin...

journal_title：Pituitary

authors： Koutroumpi S,Spiezia L,Albiger N,Barbot M,Bon M,Maggiolo S,Gavasso S,Simioni P,Frigo A,Mantero F,Scaroni C

更新日期：2014-02-01 00:00:00