Venous thromboembolism in patients with Cushing's syndrome: need of a careful investigation of the prothrombotic risk profile.

abstract：:We describe two young men with cystic pituitary enlargement on magnetic resonance imaging (MRI) causing hypopituitarism. The first patient presented acutely unwell with headache and vomiting associated with anterior and posterior pituitary dysfunction. The second patient presented with hypopituitarism after a long his...

journal_title：Pituitary

authors： Burt MG,Morey AL,Turner JJ,Pell M,Sheehy JP,Ho KK

更新日期：2003-01-01 00:00:00

abstract：:In this report we emphasize the opportunity of considering the uncommon causes of chronic GH-excess in the initial diagnostic process, such as GHRH hypersecretion, especially in the presence of ambiguous pituitary neuroimaging. This topic may have an important clinical significance in order to plan the most cost-effec...

journal_title：Pituitary

authors： Verrua E,Ronchi CL,Ferrante E,Ferrari DI,Bergamaschi S,Ferrero S,Zatelli MC,Branca V,Spada A,Beck-Peccoz P,Lania AG

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Cystic prolactinoma is a variant of prolactin-secreting pituitary adenoma. The strategies for the management of cystic prolactinoma have not been addressed thoroughly in clinical guidelines. METHODS:A literature search was performed using Pubmed to review the current approaches to the treatment of cystic ...

journal_title：Pituitary

authors： Nakhleh A,Shehadeh N,Hochberg I,Zloczower M,Zolotov S,Taher R,Daoud Naccache D

更新日期：2018-08-01 00:00:00

abstract：:Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients wi...

journal_title：Pituitary

authors： Laway BA,Mir SA,Bashir MI,Bhat JR,Samoon J,Zargar AH

更新日期：2011-03-01 00:00:00

abstract：:Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotrop...

journal_title：Pituitary

authors： Gadelha MR,Kasuki L,Korbonits M

更新日期：2017-02-01 00:00:00

abstract：:The management of invasive giant prolactinomas (IGP) has been an area of some controversy. The relative roles of transsphenoidal surgery, craniotomy, radiation therapy and dopamine agonist based medical therapy are gradually becoming clarified. We report the results of management of 30 patients with IGP. Surgery was t...

journal_title：Pituitary

authors： Yu C,Wu Z,Gong J

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:To evaluate the effects of somatostatin analogs and disease activity status on the upper gastrointestinal system in patients with acromegaly. METHODS:One hundred eighty-one patients with acromegaly were retrospectively assessed. The demographic, biochemical, pathologic, and radiologic data of the patients were...

journal_title：Pituitary

authors： Sahin S,Icli TB,Durcan E,Sulu C,Ozkaya HM,Hatemi AI,Kadioglu P

更新日期：2020-10-19 00:00:00

abstract：PURPOSE:It is estimated that approximately 69 million individuals worldwide will sustain a TBI each year, which accounts for substantial morbidity and mortality in both children and adults. TBI may lead to significant neuroendocrine changes, if the delicate pituitary is ruptured. In this review, we focus on the anterio...

journal_title：Pituitary

authors： Ntali G,Tsagarakis S

更新日期：2019-06-01 00:00:00

abstract：:MAP-2, a well characterized member of the microtubule associated protein (MAP) family, binds to and stabilizes microtubules and is involved in cell proliferation as well as neuronal differentiation. The aim of the present work was to study MAP-2 expression in human adenohypophyses and pituitary adenomas. To our knowle...

journal_title：Pituitary

authors： Rotondo F,Oniya K,Kovacs K,Bell CD,Scheithauer BW

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Hypophysitis develops in up to 19% of melanoma patients treated with ipilimumab, a cytotoxic T-lymphocyte antigen-4 antibody. Early detection may avert life-threatening hypopituitarism. We aimed to assess the incidence of ipilimumab-induced hypophysitis (IH) at a quaternary melanoma referral centre, and to dete...

journal_title：Pituitary

authors： De Sousa SMC,Sheriff N,Tran CH,Menzies AM,Tsang VHM,Long GV,Tonks KTT

更新日期：2018-06-01 00:00:00

abstract：:We report the case of a B-cell type pituitary lymphoma in a 65 year-old male immunocompetent patient who presented with hypogonadotropic hypogonadism and central hypothyroidism and subsequently developed pulmonary lymphoma. Only three cases of pituitary lymphoma have been previously reported, one in a patient with acq...

journal_title：Pituitary

authors： Mathiasen RA,Jarrahy R,Cha ST,Kovacs K,Herman VS,Ginsberg E,Shahinian HK

更新日期：2000-05-01 00:00:00

abstract：:The role of pituitary radiotherapy (RT) in the management of clinically non-functioning pituitary tumors (NFTs) remains controversial. Observational studies suggest that RT is effective in preventing the regrowth of NFT remnants following initial surgical debulking. However, not all tumor remnants will regrow in the a...

journal_title：Pituitary

authors： Gittoes NJ

更新日期：2003-09-01 00:00:00

abstract：:Isolated familial somatotropinomas (IFS) rarely occurs in the absence of multiple endocrine neoplasia type I (MEN1) or the Carney complex. In the present study we report two Italian siblings affected by GH-secreting adenomas. There was no history of parental consanguinity. The sister presented at 18 years of age with ...

journal_title：Pituitary

authors： De Menis E,Prezant TR

更新日期：2002-01-01 00:00:00

abstract：:We evaluated the efficacy of Gamma knife stereotactic radiosurgery (GKSR) as an adjunctive management modality for patients with drug resistant or intolerant cavernous sinus invasive prolactinomas. Twenty-two patients with cavernous sinus invasive prolactinoma underwent GKSR between 1994 and 2009. Thirteen patients we...

journal_title：Pituitary

authors： Liu X,Kano H,Kondziolka D,Park KJ,Iyer A,Shin S,Niranjan A,Flickinger JC,Lunsford LD

更新日期：2013-03-01 00:00:00

abstract：:GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be normalised after biochemical control is achieved. We aimed at comparing body composition and the cardiovascular...

journal_title：Pituitary

authors： Dimopoulou C,Sievers C,Wittchen HU,Pieper L,Klotsche J,Roemmler J,Schopohl J,Schneider HJ,Stalla GK

更新日期：2010-09-01 00:00:00

abstract：CONTEXT:Somatostatin (SST) and dopamine (DA) inhibit growth hormone (GH) secretion and proliferation of GH-secreting pituitary adenomas (GHomas) through binding to SSTR2 and D2R receptors. Chimeric SST-DA compounds (Dopastatins) display increased potency in inhibiting GH secretion, as compared with individual SST or DA...

journal_title：Pituitary

authors： Cuny T,Graillon T,Defilles C,Datta R,Zhang S,Figarella-Branger D,Dufour H,Mougel G,Brue T,Landsman T,Halem HA,Culler MD,Barlier A,Saveanu A

更新日期：2021-01-12 00:00:00

abstract：:The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of a RAS mutation in a single aggressive prolactinoma, no mutational changes have been identified. In prolactinomas, a further obstacle has been the paucity of surgical specimens suitable for molecular analysis since prolactionoma...

journal_title：Pituitary

authors： Evans CO,Moreno CS,Zhan X,McCabe MT,Vertino PM,Desiderio DM,Oyesiku NM

更新日期：2008-01-01 00:00:00

abstract：PURPOSE:Thyrotropin-secreting pituitary adenoma is a rare disorder and was recently classified as an aggressive tumor in the World Health Organization guidelines. The number of available studies on cosecreting thyrotropin/growth hormone pituitary adenoma is especially limited. METHODS:A single-center retrospective ana...

journal_title：Pituitary

authors： Li X,Lynch L,Xing H,Wang Z,Zhu J,Deng K,Wang R,Yao Y,Lian X

更新日期：2020-10-01 00:00:00

abstract：:An unusual case of tubercular granulomatous hypophysitis is reported. A sellar mass diagnosed as pituitary adenoma in MRI, showed non-caseating granulomas, glandular destruction and fibrosis in histology. Stain for acid-fast bacilli (AFB) were negative and the case was misdiagnosed as Idiopathic Granulomatous hypophys...

journal_title：Pituitary

authors： Husain N,Husain M,Rao P

更新日期：2008-01-01 00:00:00

abstract：:Clinically inapparent adrenal masses, or adrenal incidentalomas, are discovered inadvertently in the course of workup or treatment of unrelated disorders. Cortical adenoma is the most frequent type of adrenal incidentaloma accounting for approximately 50% of cases in surgical series and even greater shares in medical ...

journal_title：Pituitary

authors： Terzolo M,Reimondo G,Bovio S,Angeli A

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operat...

journal_title：Pituitary

authors： Ved R,Logier N,Leach P,Davies JS,Hayhurst C

更新日期：2018-06-01 00:00:00

abstract：:Symptomatic cerebral vasospasm (CVS) after transsphenoidal surgery (TSS) is very rare compared with vasospasm resulting from aneurysmal subarachnoid hemorrhage (SAH). Fewer than six cases documented by cerebral angiography have been reported. We evaluated the records of 15 patients in whom SAH developed after TSS. The...

journal_title：Pituitary

authors： Kim EH,Oh MC,Kim SH

更新日期：2013-06-01 00:00:00

abstract：:Arterial bleeding during transsphenoidal surgery for pituitary adenoma is known complication. This usually happens due to rupture of intracavernous carotid or delayed hemorrhage due to the carotico-cavernous fistula and/or pseudoaneurysm. There is also evidence that cavernous carotid aneurysms may occur with pituitary...

journal_title：Pituitary

authors： Berker M,Aghayev K,Saatci I,Palaoğlu S,Onerci M

更新日期：2010-06-01 00:00:00

abstract：:Nonfunctioning pituitary adenomas (NFPA) are typically benign neoplasms that can cause significant morbidity through local mass effects. MIB-1/Ki-67 and p53 immuno-reactivity are used to predict aggressive behavior but have known limitations. No marker to date is widely used to reliably predict tumor progression. Phos...

journal_title：Pituitary

authors： Hightower E,Cabanillas ME,Fuller GN,McCutcheon IE,Hess KR,Shah K,Waguespack SG,Corley LJ,Devin JK

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...

journal_title：Pituitary

authors： Hölsken A,Stache C,Schlaffer SM,Flitsch J,Fahlbusch R,Buchfelder M,Buslei R

更新日期：2014-12-01 00:00:00

abstract：:Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Ad...

journal_title：Pituitary

authors： Follin C,Wiebe T,Moëll C,Erfurth EM

更新日期：2014-02-01 00:00:00

abstract：:In this case report we describe a 38 year-old-female with galactorrhea several months after the birth of an anencephalic child. She had hyperpolactemia and imaging of the pituitary gland revealed a midline defect and a nasopharyngeal mass compatible with a meningo-(hypophyso-) encephalocele and possibly an ectopic ter...

journal_title：Pituitary

authors： Rabelink NM,Lips P,Castelijns JA

更新日期：2012-12-01 00:00:00

abstract：:Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...

journal_title：Pituitary

authors： Quintero Wolfe S,Hood B,Barker J,Benveniste RJ

更新日期：2009-01-01 00:00:00

abstract：:Non-functioning pituitary carcinomas (NFPC) are defined as tumours of adenophyseal origin with craniospinal or systemic dissemination, with the absence of a hormonal hypersecretion syndrome. These are a histologically heterogenous group of tumours, comprising gonadotroph, null cell, "silent" tumours of corticotroph, s...

journal_title：Pituitary

authors： Lenders N,McCormack A

更新日期：2018-04-01 00:00:00

abstract：:Glucocorticoids are important immunosuppressive hormones; these steroids also inhibit somatic growth by decreased growth hormone (GH) secretion and induced protein catabolism. The ability of ghrelin, the endogenous ligand for the GHS-1a receptor, to increase body weight is attributed to a combination of enhanced food ...

journal_title：Pituitary

authors： Tulipano G,Taylor JE,Halem HA,Datta R,Dong JZ,Culler MD,Bianchi I,Cocchi D,Giustina A

更新日期：2007-01-01 00:00:00