Abstract:
:The diagnoses of acromegaly and dwarfism require biochemical confirmation of abnormal GH and IGF-1 concentrations. The same parameters are used for therapeutic decisions, i.e. initiation or termination of particular treatments. Therefore, reliable and epidemiologically and statistically proven criteria of normalcy for GH and IGF-1 are required for these tasks to be accomplished. Despite major progress in all these areas, the definition of what constitutes "normalcy" of the somatotropic axis is still lacking. Using an example of acromegaly, we discuss the contradictions and the uncertainties of the biochemical diagnosis of this disease.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Barkan ALdoi
10.1007/s11102-007-0029-7subject
Has Abstractpub_date
2007-01-01 00:00:00pages
135-9issue
2eissn
1386-341Xissn
1573-7403journal_volume
10pub_type
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