Staging and managing patients with acromegaly in clinical practice: baseline data from the SAGIT® validation study.

Abstract:

PURPOSE:The SAGIT® instrument, designed to assist clinicians to stage acromegaly, assess treatment response and adapt patient management, was well received by endocrinologists in a pilot study. We report an interim analysis of baseline data from the validation phase. METHODS:The SAGIT® validation study (ClinicalTrials.gov NCT02539927) is an international, non-interventional study. Data collection included: demographic/disease characteristics; medical/surgical histories; concomitant acromegaly treatments; investigators' subjective evaluation of disease-control status (clinical global evaluation of disease control [CGE-DC]; controlled/not controlled/yet to be clarified) and clinical disease activity (active/not active); growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels; investigators' therapeutic decision. RESULTS:Of 228 patients enrolled, investigators considered disease to be controlled in 110 (48.2%), not controlled in 105 (46.1%), and yet to be clarified in 13 (5.7%) according to CGE-DC. Thirty-three patients were treatment-naïve (not controlled, n = 31; yet to be clarified, n = 2). Investigators considered 48.2% patients in the controlled and 95.2% in the not-controlled groups to have clinically active disease. In the controlled group, 29.7% of patients did not exhibit hormonal control (GH ≤ 2.5 µg/L; normalized IGF-1) and 47.3% did not have rigorous hormonal control (GH < 1.0 µg/L; normalized IGF-1) by contemporary consensus. Current acromegaly treatment was continued with no change for 91.8% of patients in the controlled and 40.0% in the not-controlled groups. CONCLUSIONS:These data highlight discrepancies between investigator-evaluated disease-control status, disease activity, hormonal control, and treatment decisions in acromegaly. Once validated, the SAGIT® instrument may assist clinicians in making active management decisions for patients with acromegaly.

journal_name

Pituitary

journal_title

Pituitary

authors

Giustina A,Bronstein MD,Chanson P,Petersenn S,Casanueva FF,Sert C,Houchard A,Melmed S

doi

10.1007/s11102-019-00977-5

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

476-487

issue

5

eissn

1386-341X

issn

1573-7403

pii

10.1007/s11102-019-00977-5

journal_volume

22

pub_type

杂志文章
  • Adverse anthropometric risk profile in biochemically controlled acromegalic patients: comparison with an age- and gender-matched primary care population.

    abstract::GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be normalised after biochemical control is achieved. We aimed at comparing body composition and the cardiovascular...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-010-0218-7

    authors: Dimopoulou C,Sievers C,Wittchen HU,Pieper L,Klotsche J,Roemmler J,Schopohl J,Schneider HJ,Stalla GK

    更新日期:2010-09-01 00:00:00

  • Late-onset X-linked adrenal hypoplasia (DAX-1, NR0B1): two new adult-onset cases from a single center.

    abstract:PURPOSE:DAX-1 (NR0B1) is an orphan nuclear receptor, which plays a critical role in development and regulation of the adrenal gland and hypothalamo-pituitary-gonadal axis. Mutations in NR0B1 lead to adrenal hypoplasia congenita (AHC), hypogonadotropic hypogonadism (HH) and azoospermia in men. Presentation is typically ...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-017-0822-x

    authors: Kyriakakis N,Shonibare T,Kyaw-Tun J,Lynch J,Lagos CF,Achermann JC,Murray RD

    更新日期:2017-10-01 00:00:00

  • Outcomes of stereotactic radiosurgery and hypofractionated stereotactic radiotherapy for refractory Cushing's disease.

    abstract:PURPOSE:Hypofractionated stereotactic radiotherapy (HSRT) for refractory Cushing's disease may offer a condensed treatment schedule for patients with large tumors abutting the optic chiasm unsuitable for stereotactic radiosurgery (SRS). To-date only four patients have been treated by HSRT in the published literature. W...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-019-00992-6

    authors: Sherry AD,Khattab MH,Xu MC,Kelly P,Anderson JL,Luo G,Utz AL,Chambless LB,Cmelak AJ,Attia A

    更新日期:2019-12-01 00:00:00

  • Chiasmapexy for secondary empty sella syndrome: diagnostic and therapeutic considerations.

    abstract:PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collec...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1007/s11102-020-01104-5

    authors: Graillon T,Passeri T,Boucekine M,Meyer M,Abritti R,Bernat AL,Labidi M,Dufour H,Froelich S

    更新日期:2020-11-02 00:00:00

  • Oral estroprogestin: an alternative low cost therapy for women with postoperative persistent acromegaly?

    abstract::Oral estrogens reduce GH-induced IGF-1 production and preliminary studies have shown that adjuvant estroprogestin (EP) therapy with octreotide LAR may control disease activity in some female patients who are partially responsive to octreotide LAR. Our aim was to verify if EP alone or in combination with octreotide LAR...

    journal_title:Pituitary

    pub_type: 临床试验,杂志文章

    doi:10.1007/s11102-010-0236-5

    authors: Vallette S,Serri O

    更新日期:2010-12-01 00:00:00

  • Gene expression profiling in human null cell pituitary adenoma tissue.

    abstract::It is estimated that up to one in five individuals develops pituitary gland tumors, despite the common occurrence of these tumors, the pathogenetic mechanisms underlying their development mainly remain unknown. We studied the gene expression in null cell adenomas compared with normal pituitary by expressed sequence ta...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-007-0008-z

    authors: Hu J,Song H,Wang X,Shen Y,Chen F,Liu Y,Li S,Wang Y,Shou X,Zhang Y,Hu R

    更新日期:2007-01-01 00:00:00

  • Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies.

    abstract:PURPOSE:Endogenous Cushing's syndrome (CS) is a rare disease that results from exposure to high levels of cortisol; Cushing's disease (CD) is the most frequent form of CS. Patients with CS suffer from a variety of comorbidities that increase the risk of mortality. Surgical resection of the disease-causing lesion is gen...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1007/s11102-016-0742-1

    authors: Fleseriu M,Castinetti F

    更新日期:2016-12-01 00:00:00

  • A novel variation in the AVP gene resulting in familial neurohypophyseal diabetes insipidus in a large Italian kindred.

    abstract::Familial neurohypophyseal diabetes insipidus (FNDI) is mostly an autosomal dominant inherited disorder presenting with severe polydipsia and polyuria typically in early childhood. To date, 69 different variations in the AVP gene encoding the AVP prohormone have been identified in autosomal dominant FNDI (adFNDI). In t...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-012-0392-x

    authors: Birkegaard C,Christensen JH,Falorni A,Marzotti S,Minarelli V,Gregersen N,Rittig S

    更新日期:2013-06-01 00:00:00

  • Be careful... She has a pituitary gland in her nose.

    abstract::In this case report we describe a 38 year-old-female with galactorrhea several months after the birth of an anencephalic child. She had hyperpolactemia and imaging of the pituitary gland revealed a midline defect and a nasopharyngeal mass compatible with a meningo-(hypophyso-) encephalocele and possibly an ectopic ter...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-011-0320-5

    authors: Rabelink NM,Lips P,Castelijns JA

    更新日期:2012-12-01 00:00:00

  • Cis-unsaturated free fatty acids block VIP-mediated GH and PRL secretion by perturbing the cAMP/protein kinase A pathway.

    abstract::Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral prot...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1023/a:1009962624036

    authors: Pérez FR,Camiña JP,Menéndez C,Beiras A,Casabiell X,Casanueva FF

    更新日期:1998-04-01 00:00:00

  • Ancient views on the hypothalamic-pituitary-thyroid axis: an historical and epistemological perspective.

    abstract::The modern views on the anatomical and physiological interactions between the hypothalamus, pituitary and thyroid gland have emerged only in the last fifty years, although their historical roots may be found in a number of ancient and still not widely known ideas and observations. The regulation of energy body stores ...

    journal_title:Pituitary

    pub_type: 历史文章,杂志文章

    doi:10.1023/a:1009953723963

    authors: Toni R

    更新日期:2000-10-01 00:00:00

  • Sellar collision tumor involving pituitary gonadotroph adenoma and chondroma: a potential clinical diagnosis.

    abstract::We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with ...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-009-0199-6

    authors: Sahli R,Christ E,Kuhlen D,Giger O,Vajtai I

    更新日期:2011-12-01 00:00:00

  • What are critical outcome measures for patients receiving pituitary replacement following brain injury?

    abstract::There are scant prospective studies defining improvements in critical outcome measures with hormone replacement in hypopituitarism secondary to brain injury. We review the tests of cognition and physical function and summarize their use for subjects that are deficient in anterior hormone production during anterior pit...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1007/s11102-008-0133-3

    authors: Beca SG,High WM Jr,Masel BE,Mossberg KA,Urban RJ

    更新日期:2012-03-01 00:00:00

  • The extended, transnasal, transsphenoidal approach for anterior skull base meningioma: considerations in patient selection.

    abstract:PURPOSE:In this study, we set out to define our institutional criteria for patient eligibility for transsphenoidal resection of parasellar meningiomas, and to report our experience with extended transnasal approaches for these lesions. We aimed to discuss the important considerations of patient selection and risk strat...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-017-0818-6

    authors: Castlen JP,Cote DJ,Zaidi HA,Laws ER Jr

    更新日期:2017-10-01 00:00:00

  • Effect of gsp oncogene on somatostatin receptor subtype 1 and 2 mRNA levels in GHRH-responsive GH3 cells.

    abstract::Growth hormone releasing hormone (GHRH) signals via G protein-coupled receptors (GHRH-R) to enhance intracellular Galphas/adenylyl cyclase/cAMP signaling, which in turn has positive effects on GH synthesis and release, as well as proliferation of the GH-producing cells of the anterior pituitary gland. Some GH-producin...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-005-5245-4

    authors: Kim E,Sohn S,Lee M,Park C,Jung J,Park S

    更新日期:2005-01-01 00:00:00

  • Thrombin generation in Cushing's Syndrome: do the conventional clotting indices tell the whole truth?

    abstract::Cushing's Syndrome (CS) is associated with an increased mortality, where hypercoagulability seems to have a crucial role in both arterial and venous thrombosis. Parameters of in vitro thrombin generation (TG) such as lag time, peak thrombin and endogenous thrombin potential (ETP), that describe the time until thrombin...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-013-0467-3

    authors: Koutroumpi S,Spiezia L,Albiger N,Barbot M,Bon M,Maggiolo S,Gavasso S,Simioni P,Frigo A,Mantero F,Scaroni C

    更新日期:2014-02-01 00:00:00

  • Androgen deficiency: effects on body composition.

    abstract::Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1007/s11102-008-0121-7

    authors: Miller KK

    更新日期:2009-01-01 00:00:00

  • Fatal inflammatory hypophysitis.

    abstract::A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infi...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-007-0016-z

    authors: McIntyre EA,Perros P

    更新日期:2007-01-01 00:00:00

  • Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, Phase II study in Cushing's disease.

    abstract:PURPOSE:In a 10-week proof-of-concept study (LINC 1), the potent oral 11β-hydroxylase inhibitor osilodrostat (LCI699) normalized urinary free cortisol (UFC) in 11/12 patients with Cushing's disease. The current 22-week study (LINC 2; NCT01331239) further evaluated osilodrostat in patients with Cushing's disease. METHO...

    journal_title:Pituitary

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s11102-015-0692-z

    authors: Fleseriu M,Pivonello R,Young J,Hamrahian AH,Molitch ME,Shimizu C,Tanaka T,Shimatsu A,White T,Hilliard A,Tian C,Sauter N,Biller BM,Bertagna X

    更新日期:2016-04-01 00:00:00

  • Pituitary tuberculosis mimicking idiopathic granulomatous hypophysitis.

    abstract::An unusual case of tubercular granulomatous hypophysitis is reported. A sellar mass diagnosed as pituitary adenoma in MRI, showed non-caseating granulomas, glandular destruction and fibrosis in histology. Stain for acid-fast bacilli (AFB) were negative and the case was misdiagnosed as Idiopathic Granulomatous hypophys...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-007-0068-0

    authors: Husain N,Husain M,Rao P

    更新日期:2008-01-01 00:00:00

  • Pituitary stem cells: candidates and implications.

    abstract::The pituitary is the master endocrine gland of the body. It undergoes many changes after birth, and these changes may be mediated by the differentiation of pituitary stem cells. Stem cells in any tissue source must display (1) pluripotent capacity, (2) capacity for indefinite self-renewal, and (3) a lack of specializa...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1007/s11102-013-0470-8

    authors: Nassiri F,Cusimano M,Zuccato JA,Mohammed S,Rotondo F,Horvath E,Syro LV,Kovacs K,Lloyd RV

    更新日期:2013-09-01 00:00:00

  • Aerosolisation in endonasal endoscopic pituitary surgery.

    abstract:PURPOSE:To determine the particle size, concentration, airborne duration and spread during endoscopic endonasal pituitary surgery in actual patients in a theatre setting. METHODS:This observational study recruited a convenience sample of three patients. Procedures were performed in a positive pressure operating room. ...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-021-01125-8

    authors: Dhillon RS,Nguyen LV,Rowin WA,Humphries RS,Kevin K,Ward JD,Yule A,Phan TD,Zhao YC,Wynne D,McNeill PM,Hutchins N,Scott DA

    更新日期:2021-01-19 00:00:00

  • Craniopharyngioma surgery.

    abstract::Ideal surgical treatment of craniopharyngiomas remains a major challenge for neurosurgeons. Craniopharyngiomas grow in the deep-seated hypothalamic area that is paramount for vegetative, emotional and endocrine function, and for maintaining worthwhile life. The benign histological nature of craniopharyngiomas belies t...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1007/s11102-008-0137-z

    authors: Honegger J,Tatagiba M

    更新日期:2008-01-01 00:00:00

  • Endoscopic endonasal approach for pituitary adenomas: a series of 555 patients.

    abstract:PURPOSE:To report the results of a consecutive series of patients who underwent an endoscopic endonasal approach (EEA) for resection of a pituitary adenoma and compare them to previous series of microscopic and endoscopic approaches. METHODS:A retrospective review of clinical and radiographic outcomes of a consecutive...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-013-0502-4

    authors: Paluzzi A,Fernandez-Miranda JC,Tonya Stefko S,Challinor S,Snyderman CH,Gardner PA

    更新日期:2014-08-01 00:00:00

  • Pituitary xanthogranulomas: clinical features, radiological appearances and post-operative outcomes.

    abstract:BACKGROUND:Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operat...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-017-0859-x

    authors: Ved R,Logier N,Leach P,Davies JS,Hayhurst C

    更新日期:2018-06-01 00:00:00

  • Minor tumour shrinkage in nonfunctioning pituitary adenomas by long-term treatment with the dopamine agonist cabergoline.

    abstract:OBJECTIVE:The purpose of this study was to define safety and efficacy of medical therapy in the treatment of nonfunctioning pituitary tumours. DESIGN:We studied thirteen patients with a clinically nonfunctioning pituitary macroadenoma for response to cabergoline treatment for 1 year. Twelve/13 patients were already op...

    journal_title:Pituitary

    pub_type: 临床试验,杂志文章

    doi:10.1023/a:1015366923810

    authors: Lohmann T,Trantakis C,Biesold M,Prothmann S,Guenzel S,Schober R,Paschke R

    更新日期:2001-08-01 00:00:00

  • Management of recurrent pituitary cysts with pituitary-nasal drain.

    abstract::Pituitary cysts are usually craniopharyngiomas or remnants of Rathke's cleft. Histologically craniopharyngiomas are lined by stratified squamous epithelium whereas Rathke's cleft cysts are lined by cuboidal or columnar epithelium. The management of pituitary cysts remains difficult because of the risks associated with...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1023/a:1025373715860

    authors: Dashora U,Mathias D,James A,Zammit-Maempel I,Perros P

    更新日期:2002-01-01 00:00:00

  • Drugs and prolactin.

    abstract::Medications commonly cause hyperprolactinemia and their use must be differentiated from pathologic causes. The most common medications to cause hyperprolactinemia are the antipsychotic agents, although some of the newer atypical antipsychotics do not do so. Other medications causing hyperprolactinemia include antidepr...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1007/s11102-008-0106-6

    authors: Molitch ME

    更新日期:2008-01-01 00:00:00

  • Hematologic neoplasias and acromegaly.

    abstract::We report a 59-year-old acromegalic woman, who presented with generalized bone pain, weakness, fatigue and foamy urine, who was found to have multiple myeloma (MM); and a 60-year-old acromegalic woman with dizziness, vomiting and abdominal pain, high blood pressure and splenomegaly that was posteriorly diagnosed as ha...

    journal_title:Pituitary

    pub_type: 杂志文章

    doi:10.1007/s11102-009-0176-0

    authors: Barbosa FR,Vieira Neto L,Lima GA,Wildemberg LE,Portugal R,Gadelha MR

    更新日期:2011-12-01 00:00:00

  • Dopamine resistance of prolactinomas.

    abstract::Resistance to dopamine agonists can be defined with respect to failure to normalize PRL levels and failure to decrease tumor size by > or = 50%. Using these definitions, failure to normalize PRL levels is seen in 24% of those treated with bromocriptine, 13% of those treated with pergolide and 11% of those treated with...

    journal_title:Pituitary

    pub_type: 杂志文章,评审

    doi:10.1023/a:1026225625897

    authors: Molitch ME

    更新日期:2003-01-01 00:00:00