Abstract:
:Ideal surgical treatment of craniopharyngiomas remains a major challenge for neurosurgeons. Craniopharyngiomas grow in the deep-seated hypothalamic area that is paramount for vegetative, emotional and endocrine function, and for maintaining worthwhile life. The benign histological nature of craniopharyngiomas belies their biological behavior and the propensity to recur is a major threat. Surgical treatment has to weigh the risk of hypothalamic damage against the risk of tumor recurrence or progression. Both aggressive surgery and conservative minor surgery followed by radiotherapy has been proclaimed by the proponents of different schools. During the past decade, the pendulum has swung back to surgery with the attempt at radical removal. Refined neurosurgical techniques and innovative approaches yielded improved surgical results. The contemporary neurosurgical strategy of treating craniopharyngiomas with early and late outcome data is presented. Neurosurgical therapy is only beneficial in the context of an interdisciplinary treatment concept as discussed here.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Honegger J,Tatagiba Mdoi
10.1007/s11102-008-0137-zsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
361-73issue
4eissn
1386-341Xissn
1573-7403journal_volume
11pub_type
杂志文章,评审相关文献
Pituitary文献大全abstract:INTRODUCTION:Autoimmune lymphocytic hypophysitis associates predominantly with other autoimmune endocrinopathies and is most commonly treated with glucocorticoids and/or decompressive pituitary surgery. Here we report a new association and treatment modality for lymphocytic hypophysitis. METHODS:A 52-year-old woman pr...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0592-7
更新日期:2015-08-01 00:00:00
abstract::Non-functioning pituitary neuroendocrine tumors do not cause endocrine symptoms related to hypersecretion of adenohypophyseal hormones and are clinically characterized by symptoms due to growing sellar tumor mass. Histopathological classification of this tumor group has always been challenging due to their heterogenei...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-017-0855-1
更新日期:2018-04-01 00:00:00
abstract::We report the case of a 60 year old male who complained of headache and blurry vision--that progressed to left ophthalmoplegia and ptosis--after receiving a dose of leuprolide for Prostate cancer therapy. Imaging showed a hemorrhagic sellar mass. The patient underwent transsphenoidal debulking, and the tissue obtained...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-009-0202-2
更新日期:2010-01-01 00:00:00
abstract::We report a 59-year-old acromegalic woman, who presented with generalized bone pain, weakness, fatigue and foamy urine, who was found to have multiple myeloma (MM); and a 60-year-old acromegalic woman with dizziness, vomiting and abdominal pain, high blood pressure and splenomegaly that was posteriorly diagnosed as ha...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0176-0
更新日期:2011-12-01 00:00:00
abstract::A 57-year-old woman presented with 2-year history of polyuria and polydipsia. Hormonal studies revealed almost normal anterior pituitary function and central diabetes insipidus. Magnetic resonance imaging showed thickening of the pituitary stalk and enlargement of the neurohypophysis without high intensity of the post...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1009914711287
更新日期:1999-05-01 00:00:00
abstract::Resistance to dopamine agonists can be defined with respect to failure to normalize PRL levels and failure to decrease tumor size by > or = 50%. Using these definitions, failure to normalize PRL levels is seen in 24% of those treated with bromocriptine, 13% of those treated with pergolide and 11% of those treated with...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1026225625897
更新日期:2003-01-01 00:00:00
abstract::Glucocorticoids are important immunosuppressive hormones; these steroids also inhibit somatic growth by decreased growth hormone (GH) secretion and induced protein catabolism. The ability of ghrelin, the endogenous ligand for the GHS-1a receptor, to increase body weight is attributed to a combination of enhanced food ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0054-6
更新日期:2007-01-01 00:00:00
abstract::Pituitary cysts are usually craniopharyngiomas or remnants of Rathke's cleft. Histologically craniopharyngiomas are lined by stratified squamous epithelium whereas Rathke's cleft cysts are lined by cuboidal or columnar epithelium. The management of pituitary cysts remains difficult because of the risks associated with...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1025373715860
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Patients treated for pituitary adenomas generally report a reduced quality of life (QoL). At present, the patient's perspective of QoL has not been fully addressed and this, and further insight in potential determinants of QoL in pituitary diseases is required to design strategies to improve QoL. We aimed to de...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0561-1
更新日期:2015-02-01 00:00:00
abstract::Most patients with acromegaly have some degree of insulin resistance. The principal mediator of insulin resistance in acromegaly is hypersecretion of growth hormone. Growth hormone acts at several levels to block insulin actions including inhibiting phosphorylation of the insulin receptor and one of its principal sign...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1023321421760
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:To provide an overview of fundamental concepts in machine learning (ML), review the literature on ML applications in imaging analysis of pituitary tumors for the last 10 years, and highlight the future directions on potential applications of ML for pituitary tumor patients. METHOD:We presented an overview of t...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-019-01026-x
更新日期:2020-06-01 00:00:00
abstract::The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database) were studied before a...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-011-0356-6
更新日期:2012-12-01 00:00:00
abstract:INTRODUCTION:Temozolomide (TMZ) is an oral alkylating agent that has been used over the past 8 years to treat aggressive pituitary tumors resistant to conventional therapy. To date, only 25 patients treated with TMZ for ACTH producing pituitary tumors (14 adenomas and 11 carcinomas) have been reported. MATERIALS AND M...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-015-0694-x
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collec...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-020-01104-5
更新日期:2020-11-02 00:00:00
abstract::A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0016-z
更新日期:2007-01-01 00:00:00
abstract:INTRODUCTION:Cystic prolactinoma is a variant of prolactin-secreting pituitary adenoma. The strategies for the management of cystic prolactinoma have not been addressed thoroughly in clinical guidelines. METHODS:A literature search was performed using Pubmed to review the current approaches to the treatment of cystic ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-018-0888-0
更新日期:2018-08-01 00:00:00
abstract::Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0121-7
更新日期:2009-01-01 00:00:00
abstract::A 54-years-old woman diagnosed of myotonic dystrophy (MyD) with past medical history of massive postpartum haemorrhage at age 28 and panhypopituitarism was studied. BMI and body composition were determined and we determined baseline serum IGF-I, IGFBP3, insulin and leptin levels and after the IGF-I generation test per...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1009984505312
更新日期:1999-01-01 00:00:00
abstract::Wegener's granulomatosis (WG) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis of small and medium-sized vessels. Pituitary involvement in WG is rare with only 22 previous case reports in the English medical literature between 1966 and 2006. Herein we report another patient with WG-rela...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0021-2
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality. MATERIALS AND METHODS:This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particu...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-014-0631-4
更新日期:2015-04-01 00:00:00
abstract::Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0084-8
更新日期:2009-01-01 00:00:00
abstract::The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0022-1
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To report the results of a consecutive series of patients who underwent an endoscopic endonasal approach (EEA) for resection of a pituitary adenoma and compare them to previous series of microscopic and endoscopic approaches. METHODS:A retrospective review of clinical and radiographic outcomes of a consecutive...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0502-4
更新日期:2014-08-01 00:00:00
abstract::Adequate ADH secretion, adrenal and thyroid functions are vital during the acute and post-acute phases of TBI. Deficiencies of these functions as a result of TBI are increasingly recognized. During the acute phase of TBI the incidence of severe DI is 2.9%; the incidence of less severe forms of DI is 21.6-26%. The deve...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-006-6049-x
更新日期:2005-01-01 00:00:00
abstract::Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Ad...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0459-8
更新日期:2014-02-01 00:00:00
abstract::Postoperative serum cortisol is used as an indicator of Cushing's disease (CD) remission following transsphenoidal surgery (TSS) and guides (controversially) the need for immediate adjuvant treatment for CD. We investigated postoperative cortisol and adrenocorticotropic hormone (ACTH) levels as predictors of remission...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0455-z
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:The SAGIT® instrument, designed to assist clinicians to stage acromegaly, assess treatment response and adapt patient management, was well received by endocrinologists in a pilot study. We report an interim analysis of baseline data from the validation phase. METHODS:The SAGIT® validation study (ClinicalTrials...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-019-00977-5
更新日期:2019-10-01 00:00:00
abstract::We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0199-6
更新日期:2011-12-01 00:00:00
abstract::Patients with adult GH deficiency (AGHD) have a high cardiovascular risk and probably an alteration of the oxidative balance, although evidence is lacking. To evaluate the presence of endothelial dysfunction and oxidative stress in patients with AGHD. Biochemical parameters of oxidative stress and endothelial dysfunct...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-011-0374-4
更新日期:2012-12-01 00:00:00
abstract::Meningiomas account for about 1% of sellar masses. Although they can mimic pituitary adenomas, they are more vascularized and invasive. To gain insights that would enhance our ability to establish a pre-surgical diagnosis of meningioma, we performed a retrospective study of these tumors. Query of the surgical patholog...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0507-z
更新日期:2014-08-01 00:00:00