Versatility of peroxisomes: An evolving concept.

Abstract:

:Research spanning almost 50 years has highlighted unique characteristics and irreplaceable list of diverse functions performed by peroxisomes in various model systems. Peroxisomes are single membrane bound highly dynamic organelles ubiquitous to most eukaryotic cells. Proliferation by division of pre-existing organelles and the role of endoplasmic reticulum in the biogenesis of these organelles is now well established. The earliest identified conserved functions of peroxisomes are β-oxidation of fatty acids and reactive oxygen species metabolism. Several studies over the last few decades have reported the importance of this organelle and its numerous cell type, tissue and environment-dependent functions. Their role in several aspects of human health and disease is now under investigation. Studies related to peroxisome biology and functions are now also extended to diverse model systems like Drosophila melanogaster, trypanosomatids, etc. Peroxisomes also intricately collaborate and carry out these functions together with several other organelles in a cell. In this review, we aim to present an overview of our current knowledge of the repertoire of functions of peroxisomes in various model systems.

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Deb R,Nagotu S

doi

10.1016/j.tice.2017.03.002

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

209-226

issue

2 Pt B

eissn

0040-8166

issn

1532-3072

pii

S0040-8166(17)30018-6

journal_volume

49

pub_type

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