Abstract：
:When adult rat hepatocytes were cultured in plastic Petri dishes in a medium containing insulin and glucagon, supplementation with epidermal growth factor (EGF) had a pronounced effect on their viability, morphology, and biochemical integrity. Transmission and scanning electron microscopic studies showed that after 1 week cells denied EGF accumulated numerous non-electron-dense bodies and filamentous whorls, had irregular nuclei, and exhibited atypical cell surfaces. In contrast, cells grown for 2-3 weeks in the presence of EGF had well-preserved cellular organelles and remained as an epithelial-like monolayer. After 3 weeks EGF-exposed cultures were still inducible for liver-specific tyrosine aminotransferase, and both rat albumin and rat transferrin were recoverable from the culture medium. Virtually no viable cells were present at 3 weeks in EGF-deprived cultures.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Jansing R,Samsonoff WAdoi
10.1016/0040-8166(84)90040-5subject
Has Abstractpub_date
1984-01-01 00:00:00pages
157-66issue
2eissn
0040-8166issn
1532-3072pii
0040-8166(84)90040-5journal_volume
16pub_type
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