Automated identification of keratinization and keratin pearl area from in situ oral histological images.

Abstract:

:Oral squamous cell carcinoma (OSCC) has contributed 90% of oral cancer worldwide. In situ histological evaluation of tissue sections is the gold standard for oral cancer detection. Formation of keratinization and keratin pearl is one of the most important histological features for OSCC grading. This paper aims at developing a computer assisted quantitative microscopic methodology for automated identification of keratinization and keratin pearl area from in situ oral histological images. The proposed methodology includes colour space transform in YDbDr channel, enhancement of keratinized area in most significant bit (MSB) plane of Db component, segmentation of keratinized area using Chan-Vese model. The proposed methodology achieves 95.08% segmentation accuracy in comparison with (manually) experts-based ground truths. In addition, a grading index describing keratinization area is explored for grading OSCC cases (poorly, moderately and well differentiated).

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Das DK,Chakraborty C,Sawaimoon S,Maiti AK,Chatterjee S

doi

10.1016/j.tice.2015.04.009

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

349-58

issue

4

eissn

0040-8166

issn

1532-3072

pii

S0040-8166(15)00052-X

journal_volume

47

pub_type

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