Sepsis leads to thyroid impairment and dysfunction in rat model.

Abstract:

:Sepsis was a systemic response to a local infection. Apoptosis was observed in the experimental sepsis. In this study, cecal ligation and puncture (CLP)-induced sepsis was established in rats. We found that sepsis decreased thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free T3 (fT3), and free T4 (fT4). Besides, we detected the increasing expression level of Caspase-3 and increasing ratio of TUNEL positive cells in the thyroid after sepsis. Furthermore, a series of pathological ultrastructural changes were observed in thyroid follicular epithelial cells by CLP-induced sepsis. This study established a sepsis animal model and provided the cellular and molecular basis for decoding the pathological mechanism in thyroid with the occurrence of sepsis.

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Lin X,Shi S,Shi S

doi

10.1016/j.tice.2016.07.001

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

511-5

issue

5

eissn

0040-8166

issn

1532-3072

pii

S0040-8166(16)30145-8

journal_volume

48

pub_type

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