Abstract:
:Morphological and functional changes caused by diabetes in the accessory sex organs and especially the prostate have been reported by several investigators. The aim of the present study was to examine the possible deleterious effects of experimentally induced diabetes on the secretory epithelium of the ventral prostate of mice. Sixteen adult male C57BL/6J mice were divided into two groups. The diabetic group received a streptozotocin injection of 75 mg/kg, while the control group received only 0.1 ml citrate buffer, i.p. After 30 days, the diabetic state was ascertained, the animals were sacrificed and the ventral lobe of the prostate was collected for histological and ultrastructural examination. The results showed reduction in glandular epithelium cell height, increased numbers of cytoplasmic vacuoles and thickening of the extracellular matrix. In conclusion, experimental diabetes has harmful effects on the secretory epithelial cells of the ventral lobe of the prostate of mice.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Cagnon VH,Camargo AM,Rosa RM,Fabiani R,Padovani CR,Martinez FEdoi
10.1054/tice.2000.0123subject
Has Abstractpub_date
2000-08-01 00:00:00pages
275-83issue
4eissn
0040-8166issn
1532-3072pii
S0040-8166(00)90123-Xjournal_volume
32pub_type
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