In vitro-microenvironment directs preconditioning of human chorion derived MSC promoting differentiation of OPC-like cells.

Abstract:

:The loss of oligodendrocyte progenitor cells (OPC) is a hallmark of perinatal brain injury. Our aim was to develop an in vitro culture condition for human chorion-derived mesenchymal stem cells (MSC) that enhances their stem cell properties and their capability to differentiate towards OPC-like cells. MSC were grown either in serum replacement medium (SRM) or serum-containing medium (SM) and tested for their morphology, proliferation, secretome, migration, protein expression and differentiation into OPC-like cells. MSC cultured in SRM condition have distinct morphology/protein expression profile, increased cell proliferation/migration and capacity to differentiate into OPC-like cells.

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Periasamy R,Surbek DV,Schoeberlein A

doi

10.1016/j.tice.2018.04.002

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

65-70

eissn

0040-8166

issn

1532-3072

pii

S0040-8166(17)30413-5

journal_volume

52

pub_type

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