Abstract:
:The loss of oligodendrocyte progenitor cells (OPC) is a hallmark of perinatal brain injury. Our aim was to develop an in vitro culture condition for human chorion-derived mesenchymal stem cells (MSC) that enhances their stem cell properties and their capability to differentiate towards OPC-like cells. MSC were grown either in serum replacement medium (SRM) or serum-containing medium (SM) and tested for their morphology, proliferation, secretome, migration, protein expression and differentiation into OPC-like cells. MSC cultured in SRM condition have distinct morphology/protein expression profile, increased cell proliferation/migration and capacity to differentiate into OPC-like cells.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Periasamy R,Surbek DV,Schoeberlein Adoi
10.1016/j.tice.2018.04.002subject
Has Abstractpub_date
2018-06-01 00:00:00pages
65-70eissn
0040-8166issn
1532-3072pii
S0040-8166(17)30413-5journal_volume
52pub_type
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