Growth factors and chondrogenic differentiation of mesenchymal stem cells.

Abstract:

:The main purpose of the article is to review recent knowledge about growth factors and their effect on the chondrogenic differentiation of mesenchymal stem cells under in vitro conditions. Damaged or lost articular cartilage leads to progressive debilitation, which have major impact on the life quality of the affected individuals of both sexes in all age groups. Mature hyaline cartilage has a very low self-repair potential due to intrinsic properties - lack of innervation and vascular supply. Another limiting factor is low mitotic potential of chondrocytes. Small defects are healed by migration of chondrocytes, while large ones are healed by formation of inferior fibrocartilage. However, in many cases osteoarthritis develops. Recently, cellular therapy combining mesenchymal stem cells and proper differentiation factors seems to be promising tool for hyaline cartilage defects healing.

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Danišovič L,Varga I,Polák S

doi

10.1016/j.tice.2011.11.005

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

69-73

issue

2

eissn

0040-8166

issn

1532-3072

pii

S0040-8166(11)00132-7

journal_volume

44

pub_type

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