Abstract:
:The main purpose of the article is to review recent knowledge about growth factors and their effect on the chondrogenic differentiation of mesenchymal stem cells under in vitro conditions. Damaged or lost articular cartilage leads to progressive debilitation, which have major impact on the life quality of the affected individuals of both sexes in all age groups. Mature hyaline cartilage has a very low self-repair potential due to intrinsic properties - lack of innervation and vascular supply. Another limiting factor is low mitotic potential of chondrocytes. Small defects are healed by migration of chondrocytes, while large ones are healed by formation of inferior fibrocartilage. However, in many cases osteoarthritis develops. Recently, cellular therapy combining mesenchymal stem cells and proper differentiation factors seems to be promising tool for hyaline cartilage defects healing.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Danišovič L,Varga I,Polák Sdoi
10.1016/j.tice.2011.11.005subject
Has Abstractpub_date
2012-04-01 00:00:00pages
69-73issue
2eissn
0040-8166issn
1532-3072pii
S0040-8166(11)00132-7journal_volume
44pub_type
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