Abstract：
:Parathyroid hormone/parathyroid hormone-related protein receptor (PPR) signaling is known to be involved in tooth development. In bone, extracellular matrix protein osteopontin (OPN) is a negative regulator of PPR signaling in bone formation. However, the role of OPN in modulation of PPR action in tooth development is not understood. Therefore, we examined the tooth in double mutant mice. Constitutively active PPR was expressed specifically in the odontoblasts and osteoblasts (caPPR-tg) in the presence or absence of OPN. Radiographic analysis indicated that the length of the third molar (M3) and the incisor was decreased in the caPPR-tg mice compared to wild type, and such reduction in molar and incisor length was further enhanced in the absence of OPN (caPPR-tg OPN-KO). With respect to histology of incisors, caPPR-tg induced high cellularity and irregularity in odontoblastic shape and this was enhanced by the absence of OPN. These morphological observations suggest that OPN modulates PPR signaling that are involved in tooth formation.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Morishita M,Ono N,Miyai K,Nakagawa T,Hanyu R,Nagao M,Kamolratanakul P,Notomi T,Rittling SR,Denhardt DT,Kronenberg HM,Ezura Y,Hayata T,Nakamoto T,Noda Mdoi
10.1016/j.tice.2011.02.003subject
Has Abstractpub_date
2011-06-01 00:00:00pages
196-200issue
3eissn
0040-8166issn
1532-3072pii
S0040-8166(11)00042-5journal_volume
43pub_type
杂志文章相关文献
TISSUE & CELL文献大全abstract：:Many insect cells, including epidermis, fat body, ocnocytcs and pericardial cells, can very easily be induced to form long fine processes or filopodia. Filopodia contain microfilaments hut differ from epidermal feet in lacking microtubules and in having a much smaller and uniform diameter. Although they may be 10-30 m...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(87)90014-0
更新日期：1987-01-01 00:00:00
abstract：:The structure of the sclerite and intersegmental cuticle of the opithosoma of the desert scorpion, Hadrurus arizonensis, has been examined by transmission electron microscopy. The sclerite cuticle contains a four-layered epicuticle, a hyaline exocuticle, an inner exocuticle and an endocuticle. The outer part of the hy...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(79)90040-5
更新日期：1979-01-01 00:00:00
abstract：:Granulocytes (GRs) and/or plasmatocytes (PLs), the two major immunocytes in arthropods, participate in cellular encapsulation of foreign tissue. Although gap and desmosome junctions have been reported in insect capsules, smooth septate junctions are being reported for the first time by both thin section and freeze-fra...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(88)90064-x
更新日期：1988-01-01 00:00:00
abstract：:In tendon lesions, inflammation indicates the beginning of tissue repair and influences cell proliferation and the remodeling of the extracellular matrix (ECM). Low level laser (LLL) therapy has been an important method to induce tissue repair, and several studies have sought to better understand the therapeutic possi...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/j.tice.2017.05.006
更新日期：2017-08-01 00:00:00
abstract：:In lepidoptera the spermatophore is deposited in a bursa copulatrix, which is lined by a cuticle through which solubilized components of the spermatophore must be absorbed by the underlying epithelium. This study follows the route taken by the phosphorus which, with calcium, forms a significant portion of the spermato...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(91)90079-9
更新日期：1991-01-01 00:00:00
abstract：:Seawater diluted to half (1.750% salinity) is lethal for adult carps after 3 h and 15 min. At lower salinities (0.350%-0.875%), the fish survived for longer periods, but only 0.175% salinity was innocuous. In carps, adapted to 0.175% salinity, the secretory activity of pavement cells was very high and their external r...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1054/tice.2000.0149
更新日期：2001-02-01 00:00:00
abstract：:Due to the recent importance assumed by the apoptotic process as a tool in the therapeutic protocols, we investigated the onset and rate of drug-induced apoptosis in a cell model of prostatic tumor: the DU-145 cells. The human prostatic cancer cells, DU-145, have been treated with pro-apoptotic substances like puromyc...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/j.tice.2005.06.006
更新日期：2005-10-01 00:00:00
abstract：:Embryonic stem cells (ESCs) have various uses in drug toxicity, as they can be easily differentiated in vitro. However, one of the major obstacles in the assessment of these differentiated cells is the presence of a heterogeneous cell population. To circumvent this problem, purified ESC-derived desired cells by means ...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/j.tice.2012.09.009
更新日期：2013-04-01 00:00:00
abstract：:A panel of 40 monoclonal antibodies was constructed in response to cationic endothelial cell growth factor (c-ECGF), the cationic peptide mitogen isolated from endothelial mitogen. The monoclonal antibodies were assayed by dot blot for immunoreactivity to various other peptide angiogenic factors. The panel of monoclon...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(87)90040-1
更新日期：1987-01-01 00:00:00
abstract：:Docetaxel (DCT) is an anticancer drug which acts by disrupting microtubule dynamics in the highly mitotic cancer cells. Thus, this drug has a potential to affect function and organization of tissues exhibiting high cellular turnover. We investigated, in the rabbit, the effects of a single human equivalent dose (6.26 m...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/j.tice.2014.04.005
更新日期：2014-06-01 00:00:00
abstract：:On dark-adaptation of the 11-day adult eye, the rhabdomers move towards the cuticle. Each c-c-r array (of tandem centrioles and ciliary root) maintains its position relative to the rhabdomere, and the length of the root is apparently unchanged. The close association of the array with the rhabdomere is not established ...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(75)90038-5
更新日期：1975-01-01 00:00:00
abstract：:Autologous fibrin has been widely used in surgical procedures for both soft and hard tissue repair. There are different protocols and devices to obtain this matrix, with varying centrifugal time, gravity force, speed, angle of the sample tube and spinning radius. The aim of this study was to compare three methods of o...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/j.tice.2020.101407
更新日期：2020-12-01 00:00:00
abstract：:Kupffer's vesicle, a transitory organ peculiar to teleost embryos, was investigated in embryos of Fundulus heteroclitus by scanning electron microscopy. The roof of the vesicle is constructed to rather large columnar cells which are in continuity wiht hypoblast cells. Each of the roof cells is adorned with a single lo...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(78)90003-4
更新日期：1978-01-01 00:00:00
abstract：:The second half of the 20th century has witnessed the birth and growth of biological ultrastructure research--a branch of cell biology in which electron microscopy plays an important role. After a humble start in around 1950, when only a limited arsenal of instrumentation was available, a wealth of auxiliary methodolo...
journal_title：Tissue & cell
pub_type： 历史文章,杂志文章,评审
doi：10.1016/j.tice.2003.11.001
更新日期：2004-04-01 00:00:00
abstract：:Epithelial and peritubular cells associated with the reproductive tract of the snail, Limnaea stagnalis, contain an extensive system of endoplasmic reticulum that is often dilated with many closely packed intracisternal tubules. The intracisternal tubules are approximately 24-28 nm in diameter and they are often hexag...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(84)90059-4
更新日期：1984-01-01 00:00:00
abstract：:The albumen gland of Pomacea paludosa, a prosobranch gastropod, contains two main ducts. The albumen gland duct consists of a single layer of secretory and non-secretory cells. The surface of the non-secretory cells is covered with cilia. Microvilli are associated with the luminal edges of the secretory cells. Globule...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(84)90022-3
更新日期：1984-01-01 00:00:00
abstract：:Two systems of microtubules appear to be functionally significant in the transformation of a small cell into an elongated, acellular 'corkscrew', which represents the anterior region of a sperm bundle of Pseudococcus obscurus. One system of microtubules lies within the cell; it is oriented parallel to the long axis of...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/s0040-8166(71)80029-0
更新日期：1971-01-01 00:00:00
abstract：:Head and neck cancers are common in several regions of the world and the treatment usually includes radiotherapy. This treatment can generate adverse effects to the salivary flow, with a relationship between the dose and the damage caused. Salivary gland cells are highly permeable to water and therefore, they express ...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/j.tice.2018.06.006
更新日期：2018-08-01 00:00:00
abstract：:The imaginal antenna of the male silkmoth Antheraea polyphemus is a feather-shaped structure consisting of about 30 flagellomeres, each of which gives off two pairs of side branches. During the pupal stage (lasting for 3 weeks), the antenna develops from a leaf-shaped, flattened epidermal sac ('antennal blade') via tw...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/s0040-8166(95)80048-4
更新日期：1995-06-01 00:00:00
abstract：:Kidney cells of the marine stickleback Spinachia have been studied with histochemical methods for the demonstration of glycoconjugates. The fine structure of epithelial cells is described. Mucus threads in the nephronic tubule of sexually mature consist of neutral glycoprotein which corresponds with the secretory gran...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(79)90060-0
更新日期：1979-01-01 00:00:00
abstract：:Antiserum to leucokinin I, a neuropeptide originally isolated from the cockroach Leucophaea maderae, was used for immunocytochemical labeling of neurons in the brain and ventral ganglia of the moth Spodoptera litura during postembryonic development. In the ventral ganglia, leucokinin-like immunoreactivity begins to oc...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/s0040-8166(98)80008-6
更新日期：1998-02-01 00:00:00
abstract：:As part of an ongoing comparative fine structural study, the retinal pigment epithelium (RPE), choriocapillaris and complexus basalis (Bruch's membrane) in the emu (Dromaius novaehollandiae) have been investigated by light and electron microscopy. The RPE consists of a single layer of cuboidal cells joined basally by ...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/s0040-8166(98)80063-3
更新日期：1998-04-01 00:00:00
abstract：:The subcellular distribution of calcium has been investigated in samples, from the intestinal mucosa of 10-day rats, prepared for X-ray microanalysis by various techniques designed to minimize the loss of this element. Calcium retention and its threshold of detection was most satisfactory in freeze-dried frozen thin s...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(83)90073-3
更新日期：1983-01-01 00:00:00
abstract：:Examination of livers from transgenic mice over expressing human growth hormone (hGH) revealed numerous alterations including a striking incidence of mitotic figures. The reason for increased proliferation is unclear, but could be related to effects of hGH, which is also acting as a lactogen in rodents. In order to id...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(94)90029-9
更新日期：1994-06-01 00:00:00
abstract：:A hydrogenosome is a hydrogen-producing organelle, evolutionary related to mitochondria and is found in Parabasalia protozoa, certain chytrid fungi and certain ciliates. It displays similarities to and differences from mitochondria. Hydrogenosomes are spherical or slightly elongated organelles, although very elongated...
journal_title：Tissue & cell
pub_type： 杂志文章,评审
doi：10.1016/j.tice.2009.01.001
更新日期：2009-06-01 00:00:00
abstract：:The present study reports on the ultrastructure features of spermatozoa and spermatogenesis of several species of Dysderidae (Dysdera crocata, Dysdera erythrina, Dysdera ninnii, Harpactea arguta, Harpactea piligera, Dasumia taeniifera). Dysderid spiders are known to possess a peculiar sperm transfer form known as syns...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/j.tice.2004.08.001
更新日期：2004-12-01 00:00:00
abstract：:The electron microscopical changes in the glial lacunar network that surrounds the large neurons of meso- and metacerebrum of land snail cerebral ganglia were considered, in order to get an insight into the functional role of this peculiar structure in invertebrates. Compared with snails during the active period, in t...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/s0040-8166(97)80056-0
更新日期：1997-10-01 00:00:00
abstract：:The epithelial cell morphology and distribution in the utero-tubal junction and isthmus of pigs was documented by scanning electron microscopy around ovulation. In animals mated at different times before slaughter, our observations confirmed that the utero-tubal junction and posterior part of the isthmus regulate the ...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(81)90043-4
更新日期：1981-01-01 00:00:00
abstract：:Fluorescent staining of Rhodnius prolixus ovarioles with rhodaminylphalloidin revealed an elaborate interconnecting meshwork of F-actin encasing the microtubule rich core. The thick actin struts have branches extending partially into the nurse cell lobes extending from the syncytical core. Basally the network ends at ...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(86)90075-3
更新日期：1986-01-01 00:00:00
abstract：:Pelagic amphipods belonging to the genus Phronima have four compound eyes; two lateral eyes and two large transparent medial eyes which comprise the entire top of the head. The eyes are structurally similar but the crystalline cones of the medial eyes are more than twenty times as long as those of the lateral eyes, re...
journal_title：Tissue & cell
pub_type： 杂志文章
doi：10.1016/0040-8166(77)90010-6
更新日期：1977-01-01 00:00:00
