Is the Golgi apparatus the obligatory final step for lipoprotein secretion by intestinal cells?

Abstract:

:It is currently admitted that the synthesis and excretion of triglyceride-rich lipoproteins (chylomicrons and 'small chylomicrons') by intestinal epithelial cells involves the Golgi apparatus as an obligatory final step before exocytosis. The cells of the proximal intestine of the trout are an excellent model for investigating functional compartmentalization in the course of lipid absorption. Using this model, our data invalidate morphological data which were the basis for considering the Golgi apparatus as the mandatory final stage for their secretion. In particular, we show that triglyceride-rich particles can be transported directly from the endoplasmic reticulum to the intercellular space. Two pathways of intestinal lipoprotein excretion appear to coexist. One follows the classical export route, the second functions in a manner that bypasses the Golgi apparatus. The arguments used to affirm the requirement for the Golgi apparatus as a final step (glycosylation of apoprotein B, membrane vehicle for exocytosis) are discussed.

journal_name

Tissue Cell

journal_title

Tissue & cell

authors

Vernier JM,Sire MF

doi

10.1016/0040-8166(86)90064-9

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

447-60

issue

3

eissn

0040-8166

issn

1532-3072

pii

0040-8166(86)90064-9

journal_volume

18

pub_type

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