Abstract:
:It is currently admitted that the synthesis and excretion of triglyceride-rich lipoproteins (chylomicrons and 'small chylomicrons') by intestinal epithelial cells involves the Golgi apparatus as an obligatory final step before exocytosis. The cells of the proximal intestine of the trout are an excellent model for investigating functional compartmentalization in the course of lipid absorption. Using this model, our data invalidate morphological data which were the basis for considering the Golgi apparatus as the mandatory final stage for their secretion. In particular, we show that triglyceride-rich particles can be transported directly from the endoplasmic reticulum to the intercellular space. Two pathways of intestinal lipoprotein excretion appear to coexist. One follows the classical export route, the second functions in a manner that bypasses the Golgi apparatus. The arguments used to affirm the requirement for the Golgi apparatus as a final step (glycosylation of apoprotein B, membrane vehicle for exocytosis) are discussed.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Vernier JM,Sire MFdoi
10.1016/0040-8166(86)90064-9subject
Has Abstractpub_date
1986-01-01 00:00:00pages
447-60issue
3eissn
0040-8166issn
1532-3072pii
0040-8166(86)90064-9journal_volume
18pub_type
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