Abstract:
:Acne is the most common skin disorder and can directly affect the patients' self-esteem. Systemic treatment has been indicated for nodular, cystic or persistent acne rather than another type of treatment, such as a topic one. Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands the disease can be controlled. This study was designed to mimic the treatment performed in young patients using the dosage of 1mg/kg, and a higher one of 10mg/kg, for 60days in young male Wistar rats. 24 Wistar rats were divided into four groups: control(water), D0(soybean oil, control group), D1(1mg/kg of Isotretinoin solution), D10(10mg/kg of Isotretinoin solution). Using the morphometry tool and histochemical techniques we evaluated the villus, intestinal crypts, and goblet cells to find signs of possible alterations of the duodenum, jejunum and ileum segments of the small intestine. We found no signs of changes in the jejunum mucosa after 60 days of treatment with 1mg/kg and 10mg/kg. The duodenum is also less affected, whereas significant modifications were found in the ileum. The goblet cell frequency was altered, indicating a proliferative potential for the substance. Although some patients have described intestinal symptoms, no important alterations were found with this protocol, reaffirming the security involved in the treatment with this substance.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Thomazini BF,Dolder MAdoi
10.1016/j.tice.2017.03.003subject
Has Abstractpub_date
2017-04-01 00:00:00pages
203-208issue
2 Pt Beissn
0040-8166issn
1532-3072pii
S0040-8166(16)30297-Xjournal_volume
49pub_type
杂志文章相关文献
TISSUE & CELL文献大全abstract::The expression and localization of gap junctional proteins connexin (Cx) 26, 32, and 43 was examined in human dental pulp. Dental pulp tissues were obtained from human third molars immediately after extraction. Some pulp tissues were used for cell culture, and the rest for histological observations. Immunostaining for...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/s0040-8166(02)00028-9
更新日期:2002-06-01 00:00:00
abstract::The diabetes (db/db) and obese (ob/ob) genotype mutations induce a progressive, hypercytolipidemic condition within the endometrium of the female reproductive tract that promotes sterility and premature organ involution in C57BL/KsJ mice. The current studies focus on the ultrastructural changes that occur within the e...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2003.08.002
更新日期:2004-02-01 00:00:00
abstract::The reproductive system of the female Urodacus manicatus (Scorpionidae) is described. Situated on the ventral side of the ovariuterus tubes are buds and diverticulae belonging to three developmental phases: (1) Bud-like, rudimentary diverticulae that will form future generations. (2) Embryonic diverticulae that will h...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(94)90060-4
更新日期:1994-10-01 00:00:00
abstract::Docetaxel (DCT) is an anticancer drug which acts by disrupting microtubule dynamics in the highly mitotic cancer cells. Thus, this drug has a potential to affect function and organization of tissues exhibiting high cellular turnover. We investigated, in the rabbit, the effects of a single human equivalent dose (6.26 m...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2014.04.005
更新日期:2014-06-01 00:00:00
abstract::Responses of cells in the tick salivary gland to parasitism by Theileria parva were studied by electron microscopy. The gland is composed of three distinct types of acini (I, II, III) which together include ten or more different cell types. Of some 30 infected cells observed in the present study, all were E-cells of a...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(82)90035-0
更新日期:1982-01-01 00:00:00
abstract::We used specific markers and fluorescence microscopy to identify and characterize cerebrovascular cells. Cultures were derived from brain microvessels isolated from normotensive (Wistar Kyoto, WKY) and spontaneously hypertensive (SHR) rat brains prior to, coincident with and following the onset of chronic hypertension...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(87)90005-x
更新日期:1987-01-01 00:00:00
abstract::Routine light microscopy and transmission and scanning electron microscopy were used to describe and compare the livers of larval lampreys, Lampetra lamottenii before and during infection of the bile ducts by the nematode, Truttaedacnitis stelmioides. The hepatocytes of uninfected animals differ from other lamprey spe...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(92)90073-g
更新日期:1992-01-01 00:00:00
abstract::A detailed model for hyposmotic fluid formation in Hydra is presented. We propose that enteron fluid formation occurs in two steps: (1) segregation of an isosmotic fluid in large intercellular vacuoles with (2) subsequent reabsorption of solute in the intercellular channels to form the hyposmotic fluid of the enteron....
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(77)90045-3
更新日期:1977-01-01 00:00:00
abstract::In this study, we aimed to investigate the presence of asprosin (ASP) in the liver, kidneys, heart, stomach, testicles and brain and to determine the serum and tissue asprosin levels in diabetic rats. A total of 14 male Wistar Albino rats were divided into two groups, each containing 7 rats: (I) control group and (II)...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2020.101397
更新日期:2020-10-01 00:00:00
abstract::Testicular peritubular tissue, also known as the tunica propria, surrounds the seminiferous tubules and is responsible for contractile, paracrine and transport functions. The aim of the present report is to describe the pathomorphology of peritubular tissue in association with tubular hyalinization in human testis. Tw...
journal_title:Tissue & cell
pub_type: 临床试验,杂志文章
doi:10.1054/tice.1999.0005
更新日期:1999-02-01 00:00:00
abstract::Human amniotic mesenchymal stromal cells (hAMSCs) are considered as a population of multipotent cells. The molecular events associated with mesenchymal stromal cell (MSC)/tumor cell interactions should be studied to identify the role of MSCs on suppressing or inducing the key signaling pathways of tumor cells. Thus, d...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2020.101479
更新日期:2021-02-01 00:00:00
abstract::The epithelium of the gastric mucosa and its glands in the corpus of rat stomach contains mucous surface cells (MSCs), parietal cells, mucous neck cells (MNCs), zymogenic or chief cells (ZCs), several types of enteroendocrine cells, and intermediate cells with characteristics between MNCs and ZCs also called transitio...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2017.10.007
更新日期:2017-12-01 00:00:00
abstract::The origin of midgut epithelium may begin either from yolk cells (energids), tips of stomo- and proctodaeum (ectoderm), inner layer (endoderm) or from both kinds of the above mentioned cells. The origin of the midgut epithelium in wingless insects (Apterygota) has still not been determined. In Thermobia domestica the ...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2004.12.001
更新日期:2005-04-01 00:00:00
abstract::Junctional complexes between the epithelial cells in the four distinct regions of the glow-worm Malpighian tubule were investigated by electron microscopy using thin sectioning, freeze-fracturing, osmotic disruption and tracer techniques. The lateral plasma membranes of all four cell types are joined by smooth septate...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(80)90011-7
更新日期:1980-01-01 00:00:00
abstract::In this study we compared the effects of the Toll-like receptor (TLR) ligands lipopolysaccharide (LPS), flagellin, the synthetic bacterial triacylated lipopeptide Pam3-Cys-Ser-Lys4 (Pam3CSK4), Polyinosinic:polycytidylic acid (Poly I:C), and macrophage-activating lipopeptide (MALP-2), which are TLR4, TLR5, TLR1/2, TLR3...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2016.04.002
更新日期:2016-08-01 00:00:00
abstract::Bilateral pairs of specific neurones in the metathoracic ganglion of the cockroach were used to study the ultrastructural changes which follow axon injury. The appearance of these matched pairs of cells was compared three days after the axons on one side of the ganglion only had been severed. The control or uninjured ...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/s0040-8166(70)80039-8
更新日期:1970-01-01 00:00:00
abstract::We aimed to investigate the application of adipose-derived stromal cells in the treatment of stress urinary incontinence (SUI). Animal models of stress urinary incontinence were established with Sprague-Dawley female rats by complete cutting of the pudendal nerve. Rat adipose-derived stromal cells were isolated, cultu...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2011.04.003
更新日期:2011-08-01 00:00:00
abstract::Degeneration of intervertebral disk (IVD) has been increased in recent years. The lumbar herniation can be cured using conservative and surgical procedures. Surgery is considered after failure of conservative treatment. Partial discectomy, fusion, and total disk replacement (TDR) are also common surgical treatments fo...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2014.05.008
更新日期:2014-10-01 00:00:00
abstract::Kidney cells of the marine stickleback Spinachia have been studied with histochemical methods for the demonstration of glycoconjugates. The fine structure of epithelial cells is described. Mucus threads in the nephronic tubule of sexually mature consist of neutral glycoprotein which corresponds with the secretory gran...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(79)90060-0
更新日期:1979-01-01 00:00:00
abstract::Little is known of the cell biology of Leydig cells during the neonatal activation of the hypothalamic-pituitary-testicular (HPT) axis. The current study examined the effect of blockade of the HPT axis with a GnRH antagonist (antide) on the neonatal population of Leydig cells in the new world primate, the common marmo...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/s0040-8166(98)80084-0
更新日期:1998-12-01 00:00:00
abstract::Research spanning almost 50 years has highlighted unique characteristics and irreplaceable list of diverse functions performed by peroxisomes in various model systems. Peroxisomes are single membrane bound highly dynamic organelles ubiquitous to most eukaryotic cells. Proliferation by division of pre-existing organell...
journal_title:Tissue & cell
pub_type: 杂志文章,评审
doi:10.1016/j.tice.2017.03.002
更新日期:2017-04-01 00:00:00
abstract::Specific biomechanical characters and some structures possibly related to them were investigated in the skin of the toad Bufo marinus using tensile testing techniques (at constant strain till rupture) as well as morphological methods (histological, immunohistochemical and electronmicroscopical). Mechanical parameters ...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1054/tice.2001.0208
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:The current study proposes an automated machine learning approach for the quantification of cells in cell death pathways according to DNA fragmentation. METHODS:A total of 17 images of kidney histological slide samples from male Wistar rats were used. The slides were photographed using an Axio Zeiss Vert.A1 ...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2016.12.006
更新日期:2017-02-01 00:00:00
abstract::We established a human pancreatic carcinoma cell line, designated SPH, from cancerous ascites of a 57-year-old male patient with ductal adenocarcinoma of the pancreas. The cells have been cultured for 32 months with RPMI-1640 medium supplemental with 10% fetal calf serum. The population doubling time of this cell line...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2007.04.001
更新日期:2007-08-01 00:00:00
abstract::The morphology of the extensible intersegmental membrane (i.s.m.) of the female Locusta migratoria migratorioides is dictated by three main requirements: (a) high extensibility (1500%), (b) low stiffness (5 X 10(3) Pa), (c) low Poisson ratio in the plane of the cuticle (0.01 or less). These requirements can be met onl...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/s0040-8166(81)80017-1
更新日期:1981-01-01 00:00:00
abstract::In the crayfish Astacus leptodactylus, the podobranch, bearing respiratory and ion-transporting filaments, is attached to the lamina. The Na(+)/K(+)-ATPase activity is higher in filaments than in lamina. Using a mouse monoclonal antibody directed against the alpha subunit of Na(+)/K(+)-ATPase, and indirect immunofluor...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1054/tice.1999.0063
更新日期:1999-10-01 00:00:00
abstract::Female adults of the bagworm moth, Eumeta variegata, lack wings completely, whereas male adults of this species have functional wings. We previously found that ecdysteroid induces apoptotic events in the female wing rudiment of E. variegata in vitro, whereas the male wing discs cultured with 20-hydroxyecdysone (20E) u...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/j.tice.2011.01.003
更新日期:2011-06-01 00:00:00
abstract::Antiserum to leucokinin I, a neuropeptide originally isolated from the cockroach Leucophaea maderae, was used for immunocytochemical labeling of neurons in the brain and ventral ganglia of the moth Spodoptera litura during postembryonic development. In the ventral ganglia, leucokinin-like immunoreactivity begins to oc...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/s0040-8166(98)80008-6
更新日期:1998-02-01 00:00:00
abstract::Zebra Finches are the epitome of desert-adapted avian species; i.e. they are able to survive without drinking water for over a year. Whereas transepidermal water loss (TEWL) in naked Zebra Finch nestlings is lower than in adults, and desert adaptation is accompanied by intercellular deposition of epidermal multigranul...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/0040-8166(89)90023-2
更新日期:1989-01-01 00:00:00
abstract::We have performed studies to determine if different populations of satellite cells provide nuclei to growing and regenerating skeletal muscle fibers. Satellite cells were isolated from regenerating or growing anterior tibialis muscles, and their phenotypic properties were compared in vitro. Isolates from regenerating ...
journal_title:Tissue & cell
pub_type: 杂志文章
doi:10.1016/s0040-8166(96)80057-7
更新日期:1996-10-01 00:00:00