Abstract:
:In order to determine the effects of testosterone upon the function of the pineal gland we quantitated, under the electron microscope, the number of dense-core vesicles, lysosomes, lipid droplets and the fractional volume of the pineal gland components in adult male mice. We studied six groups of mice submitted to different treatments as follows: treated with testosterone propionate (0.1 mg/10 g body weight for 15 consecutive days), castrated and the respective control mice. In mice treated with testosterone we observed a decrease in the number and fractional volume of dense-core vesicles and an increase in the fractional volume of lysosomes and lipid droplets. In castrated mice, without treatment, we observed a decrease in the number of lysosomes and an increase in the number and fractional volume of dense-core vesicles. These results show that testosterone is closely related to the secretory process of mice pinealocytes, playing an inhibitory role upon the functional activity of the pineal gland.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Redins CA,Novaes JC,Torres KBdoi
10.1054/tice.1999.0010subject
Has Abstractpub_date
1999-04-01 00:00:00pages
233-9issue
2eissn
0040-8166issn
1532-3072pii
S0040816699900101journal_volume
31pub_type
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