Abstract：
:The role of phagocytosis in eliminating apoptotic spermatogenic cells caused by mono(2-ethylhexyl) phthalate (MEHP) was studied. Twenty-one-day-old C57Bl/6N male mice were given a single dose of 800 mg/kg MEHP in corn oil by oral gavage and sacrificed at 1, 3, 5, 7 and 9 days after initial exposure. At the same time, the role of phagocytosis in MEHP related apoptosis was examined using microinjection of annexin V into the seminiferous tubules of living mice. Results showed that mice treated with MEHP had a lower rate of testis weight gain (lower regression line) and a significant TUNEL-positive spermatogenic cell number compared to control. However, this incident was reversible, and the number of TUNEL-positive cells returned to normal after 9 days. Mice microinjected with annexin V and later treated with MEHP showed a large amount of TUNEL-positive cells compared to mice treated with MEHP only. This clearly proves that phagocytosis plays an efficient and highly important role in eliminating dead cells in the injured testis of mice treated with MEHP.
journal_name
Tissue Celljournal_title
Tissue & cellauthors
Tay TW,Andriana BB,Ishii M,Choi EK,Zhu XB,Alam MS,Tsunekawa N,Kanai Y,Kurohmaru Mdoi
10.1016/j.tice.2007.04.002subject
Has Abstractpub_date
2007-08-01 00:00:00pages
241-6issue
4eissn
0040-8166issn
1532-3072pii
S0040-8166(07)00036-5journal_volume
39pub_type
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