Abstract:
BACKGROUND:MicroRNAs are able to control vital tumor biological processes, such as proliferation, tissue transformation and cell migration, as well as apoptosis. One of the micro RNAs, namely miR-1, has been classified as a tumor suppressor, however, preliminary data did not confirm this finding in ovarian cancer (OC) cells. This study examined the impact of miR-1 on OC cell growth. MATERIALS AND METHODS:Recombinant miR-1 was overexpressed in human OC cell lines OVCAR-3, SK-OV-3, TOV-112D, and TOV-21G. Subsequently, cell growth was analyzed. RESULTS:After transfection, 11- to 487-fold overexpression of miR-1 was detectable in the OC cells. However, no significant differences in proliferation compared to control cells were detected, neither in transiently nor in stably transfected cells. CONCLUSION:In numerous cancer entities miR-1 is defined as an antiproliferative tumor suppressor. Notably, the present study demonstrated a loss of growth-inhibitory functionality of miR-1 by so far unknown mechanisms, suggesting dysregulated miR-1 signaling or effector cascades in OC cells.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Stope MB,Hettenbach D,Kaul A,Paditz M,Diesing K,Burchardt M,Zygmunt M,Mustea A,Koensgen Dsubject
Has Abstractpub_date
2016-07-01 00:00:00pages
3329-34issue
7eissn
0250-7005issn
1791-7530pii
36/7/3329journal_volume
36pub_type
杂志文章abstract:UNLABELLED:Magnetic drug targeting (MDT) is a new locoregional chemotherapy method that increases the drug dose in the tumour region, while simultaneously reducing the overall dose through the application of chemotherapeutic-bound superparamagnetic nanoparticles, which are focused by an external magnetic field to the d...
journal_title:Anticancer research
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journal_title:Anticancer research
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abstract::Pegylated liposomal doxorubicin is associated with a lower risk of cardiotoxocity than conventional formulations of doxorubicin, allowing the use of higher cumulative doses. In this Phase II study, 25 patients aged over 70 years (median 79, range 75-82 years) with aggressive non-Hodgkin's lymphoma (NHL) (International...
journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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更新日期:1998-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2009-07-01 00:00:00
abstract::260 CB57BL/J6 mice were used in an experimental protocol designed to investigate the effects of 4 different varieties of splenectomy on the growth rate of subcutaneously implanted GB-16 melanoma. In addition, the mean and absolute survival of the mice, the histopathology of the tumour and the effects of the same proce...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
更新日期:2016-05-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND/AIM:Non-pegylated liposomal doxorubicin (NPLD) has demonstrated antitumour activity equivalent to conventional doxorubicin and a significantly lower risk of cardiotoxicity. This phase II trial was performed to evaluate the activity and the safety of NPLD and ifosfamide combination in patients with metastatic...
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pub_type: 杂志文章,多中心研究
doi:
更新日期:2015-01-01 00:00:00
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doi:
更新日期:2010-05-01 00:00:00
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doi:
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更新日期:2006-01-01 00:00:00
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journal_title:Anticancer research
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doi:
更新日期:2003-05-01 00:00:00
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更新日期:2000-09-01 00:00:00
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