White Matter Changes and Confrontation Naming in Retired Aging National Football League Athletes.

abstract：:Traumatic spinal cord injury (SCI) can cause permanent disabilities that seriously reduce quality of life. We evaluated the effects of chronic hyperglycemia before SCI on inflammatory markers and functional recovery after SCI in human patients and a rat model. In the human study, multivariate logistical regression ana...

journal_title：Journal of neurotrauma

authors： Park KS,Kim JB,Keung M,Seo YJ,Seo SY,Mun SA,Lee YS,Cho DC,Hwang JH,Han I,Kim CH,Kim KT

更新日期：2020-05-01 00:00:00

abstract：:Although atrophic changes have been well described following traumatic brain injury (TBI) in humans, little is known concerning the mechanisms or progression of brain tissue loss. In the present study, we evaluated the temporal profile of histopathological changes following parasagittal fluid-percussion (FP) brain inj...

journal_title：Journal of neurotrauma

authors： Smith DH,Chen XH,Pierce JE,Wolf JA,Trojanowski JQ,Graham DI,McIntosh TK

更新日期：1997-10-01 00:00:00

abstract：:Traumatic brain damage may cause acute emotional symptoms such as uncontrolled crying, apathy, and sleep problems. Rehabilitation may be less effective in patients afflicted by these symptoms. Citalopram, a selective serotonin reuptake inhibitor (SSRI), has a documented immediate and dramatic effect on pathological cr...

journal_title：Journal of neurotrauma

authors： Andersen G,Stylsvig M,Sunde N

更新日期：1999-04-01 00:00:00

abstract：:The protective effect of chlorpromazine on rat spinal cord injury was investigated using a dynamic impact model. A 10 g weight was dropped 5 cm on an impounder placed on the exposed spinal cord at the T-11 level. Changes in potassium concentration on the epidural surface of the injured spinal cord were measured using ...

journal_title：Journal of neurotrauma

authors： Sadanaga KK,Ohnishi ST

更新日期：1989-10-01 00:00:00

abstract：:This study characterizes the histological and immunohistochemical changes in the adult rat spinal cord following photochemically induced spinal cord lesions. The spinal cord was exposed by laminectomy (T12-L1 vertebrae) and bathed with 1.5% rose bengal solution for 10 min. The excess dye was removed by saline rinse an...

journal_title：Journal of neurotrauma

authors： Verdú E,García-Alías G,Forés J,Vela JM,Cuadras J,López-Vales R,Navarro X

更新日期：2003-05-01 00:00:00

abstract：:Assessment of acute mild traumatic brain injury (mTBI) symptoms after a combat blast could aid diagnosis and guide follow-up care. Our objective was to document acute mTBI symptoms following a combat blast and to examine associations between acute symptoms and mental health and service discharge outcomes. A retrospect...

journal_title：Journal of neurotrauma

authors： Eskridge SL,Macera CA,Galarneau MR,Holbrook TL,Woodruff SI,MacGregor AJ,Morton DJ,Shaffer RA

更新日期：2013-08-15 00:00:00

abstract：:The increase in the volume of a traumatic intracerebral hemorrhage (TICH) is a widely studied phenomenon that has a direct impact on the prognosis of patients. The objective of this study was to identify the risk factors associated with the progression of TICH. We retrospectively analyzed the records of 1970 adult pat...

journal_title：Journal of neurotrauma

authors： Cepeda S,Gómez PA,Castaño-Leon AM,Martínez-Pérez R,Munarriz PM,Lagares A

更新日期：2015-08-15 00:00:00

abstract：:Poor response inhibition is a hallmark of pediatric traumatic brain injury (TBI). We assessed motor response inhibition by measuring commission error rates on Simple (minimized cognitive demands) and Motivation (monetary reward) Go/No-Go tasks, comparing 17 children with chronic TBI (>1 year post-injury) and 14 matche...

journal_title：Journal of neurotrauma

authors： Stephens JA,Salorio CF,Gomes JP,Nebel MB,Mostofsky SH,Suskauer SJ

更新日期：2017-11-15 00:00:00

abstract：:Anecdotal observations of blast victims indicate that significant neuropathological and neurobehavioral defects may develop at later stages of life. To pre-clinically model this phenomenon, we have examined neurobehavioral changes in rats up to 1 year after exposure to single and tightly coupled repeated blasts using ...

journal_title：Journal of neurotrauma

authors： Arun P,Wilder DM,Eken O,Urioste R,Batuure A,Sajja S,Van Albert S,Wang Y,Gist ID,Long JB

更新日期：2020-02-15 00:00:00

abstract：:The expression of alternatively spliced mRNAs for amyloid precursor protein (APP) isoforms and their translation products were examined in the rat cerebral cortex 1, 3, 6, and 12 h and 1, 3, and 7 days (n = 4-5 in each group) after fluid-percussion brain injury. In situ hybridization studies demonstrated that the expr...

journal_title：Journal of neurotrauma

authors： Masumura M,Hata R,Uramoto H,Murayama N,Ohno T,Sawada T

更新日期：2000-02-01 00:00:00

abstract：:This study investigated corticomotor excitability and inhibition, cognitive functioning, and fine motor dexterity in retired elite and amateur Australian football (AF) players who had sustained concussions during their playing careers. Forty male AF players who played at the elite level (n=20; mean age 49.7±5.7 years)...

journal_title：Journal of neurotrauma

authors： Pearce AJ,Hoy K,Rogers MA,Corp DT,Maller JJ,Drury HG,Fitzgerald PB

更新日期：2014-07-01 00:00:00

abstract：:The fluid-percussion technique produces experimental brain injury by rapid injection of a fluid volume into the closed cranial cavity. The experiments reported here characterize a new, more controlled technique for fluid-percussion brain injury in the rat and systematically examine systemic physiologic, histopathologi...

journal_title：Journal of neurotrauma

authors： Dixon CE,Lighthall JW,Anderson TE

更新日期：1988-01-01 00:00:00

abstract：:Axon retraction greatly limits functional recovery after spinal cord injury (SCI) and neuron polarization, which affects processes including axon formation and development, is a promising target for promoting axon regeneration. Increasing microtubule stability has been demonstrated to improve intrinsic axon regenerati...

journal_title：Journal of neurotrauma

authors： Wang Q,Cai H,Hu Z,Wu Y,Guo X,Li J,Wang H,Liu Y,Liu Y,Xie L,Xu K,Xu H,He H,Zhang H,Xiao J

更新日期：2019-06-15 00:00:00

abstract：:Much recent research has focused on the pathological significance of calcium accumulation in the central nervous system (CNS) following cerebral ischemia, spinal cord injury (SCI), and traumatic brain injury (TBI). Disturbances in neuronal calcium homeostasis may result in the activation of several calcium-sensitive e...

journal_title：Journal of neurotrauma

authors： Kampfl A,Posmantur RM,Zhao X,Schmutzhard E,Clifton GL,Hayes RL

更新日期：1997-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) is one of the most acute degenerative pathologies in the central nervous system, and in vivo indices enabling an assessment of TBI on a mechanistic basis have yet to be established. The aim of this work was to pursue neuroinflammatory changes and their link to functional disruptions of tra...

journal_title：Journal of neurotrauma

authors： Yu I,Inaji M,Maeda J,Okauchi T,Nariai T,Ohno K,Higuchi M,Suhara T

更新日期：2010-08-01 00:00:00

abstract：:Contusion-type cervical spinal cord injury (SCI) is one of the most common forms of SCI observed in patients. In particular, injuries targeting the C3-C5 region affect the pool of phrenic motor neurons (PhMNs) that innervates the diaphragm, resulting in significant and often chronic respiratory dysfunction. Using a pr...

journal_title：Journal of neurotrauma

authors： Nicaise C,Frank DM,Hala TJ,Authelet M,Pochet R,Adriaens D,Brion JP,Wright MC,Lepore AC

更新日期：2013-06-15 00:00:00

abstract：:Older adults tend to have poorer outcomes compared to younger adults following moderate-to-severe traumatic brain injury (TBI). Currently, there is a need for research focusing on how elderly TBI has changed as the U.S. population shifts. This study provides a statewide account of moderate-to-severe TBI in regard to i...

journal_title：Journal of neurotrauma

authors： Ramanathan DM,McWilliams N,Schatz P,Hillary FG

更新日期：2012-05-01 00:00:00

abstract：:Many patients with mild traumatic brain injury (MTBI) concurrently sustain extracranial injuries; however, little is known about the impact of these additional injuries on outcome. We assessed the impact of additional injuries on the severity of postconcussional symptoms (PCS) and functional outcome 6 months post-inju...

journal_title：Journal of neurotrauma

authors： Stulemeijer M,van der Werf SP,Jacobs B,Biert J,van Vugt AB,Brauer JM,Vos PE

更新日期：2006-10-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) studies have demonstrated that measures of altered metabolism and axonal injury can be detected following traumatic brain injury. The aim of this study was to characterize and compare the distributions of altered image parameters obtained by thes...

journal_title：Journal of neurotrauma

authors： Maudsley AA,Govind V,Levin B,Saigal G,Harris L,Sheriff S

更新日期：2015-07-15 00:00:00

abstract：:Diffusion tensor imaging (DTI) has demonstrated success as a biomarker of spinal cord injury (SCI) severity as shown from numerous pre-clinical studies. However, artifacts from stabilization hardware at the lesion have precluded its use for longitudinal assessments. Previous research has documented ex vivo diffusion c...

journal_title：Journal of neurotrauma

authors： Motovylyak A,Skinner NP,Schmit BD,Wilkins N,Kurpad SN,Budde MD

更新日期：2019-05-01 00:00:00

abstract：:Previous studies have shown that location and direction of injury may affect outcome in experimental models of traumatic brain injury. Significant variability in outcome data has also been noted in studies using the lateral fluid percussion brain injury model (FPI) in rats. In recent studies from our laboratory, we ob...

journal_title：Journal of neurotrauma

authors： Vink R,Mullins PG,Temple MD,Bao W,Faden AI

更新日期：2001-08-01 00:00:00

abstract：:Large-scale network analysis characterizes the brain as a complex network of nodes and edges to evaluate functional connectivity patterns. The utility of graph-based techniques has been demonstrated in an increasing number of resting-state functional MRI (rs-fMRI) studies in the normal and diseased brain. However, to ...

journal_title：Journal of neurotrauma

authors： Kaushal M,Oni-Orisan A,Chen G,Li W,Leschke J,Ward BD,Kalinosky B,Budde MD,Schmit BD,Li SJ,Muqeet V,Kurpad SN

更新日期：2017-03-15 00:00:00

abstract：:Patients with spinal cord injury (SCI) typically experience body weight loss, motor function deficits, and a general decline of physical fitness. Animal models with these characteristics can serve to study the detailed adaptive changes following SCI. In the present study, we report the use of an adult paraplegic mouse...

journal_title：Journal of neurotrauma

authors： Landry E,Frenette J,Guertin PA

更新日期：2004-08-01 00:00:00

abstract：:The majority of studies do not support the use of the prophylactic anticonvulsants studied thus far for the prevention of late PTS. Routine seizure prophylaxis later than 1 week following head injury is, therefore, not recommended. If late PTS occur, patients should be managed in accordance with standard approaches to...

journal_title：Journal of neurotrauma

authors：

更新日期：2000-06-01 00:00:00

abstract：:Traumatic injury to the central nervous system (CNS) is accompanied by the spreading damage of secondary degeneration, resulting in further loss of neurons and function. Partial transection of the optic nerve (ON) has been used as a model of secondary degeneration, in which axons of retinal ganglion cells in the ventr...

journal_title：Journal of neurotrauma

authors： Fitzgerald M,Bartlett CA,Payne SC,Hart NS,Rodger J,Harvey AR,Dunlop SA

更新日期：2010-11-01 00:00:00

abstract：:After experimental traumatic brain injury (TBI), calcineurin is upregulated; blocking calcineurin is associated with improved outcomes. In humans, variation in the calcineurin A-gamma gene (PPP3CC) has been associated with neuropsychiatric disorders, though any role in TBI recovery remains unknown. This study examines...

journal_title：Journal of neurotrauma

authors： Osier ND,Bales JW,Pugh B,Shin S,Wyrobek J,Puccio AM,Okonkwo DO,Ren D,Alexander S,Conley YP,Dixon CE

更新日期：2017-01-01 00:00:00

abstract：:Accurate localization of cerebrospinal fluid (CSF) fistula in a patient with CSF rhinorrhea is challenging and often involves multiple imaging studies with associated expense and patient discomfort. Intrathecal contrast-enhanced computed tomography (CT) and unenhanced magnetic resonance (MR) cisternography using const...

journal_title：Journal of neurotrauma

authors： Goel G,Ravishankar S,Jayakumar PN,Vasudev MK,Shivshankar JJ,Rose D,Anandh B

更新日期：2007-10-01 00:00:00

abstract：:Prognostic biomarkers for post-injury outcome are necessary for the development of neuroprotective and antiepileptogenic treatments for traumatic brain injury (TBI). We hypothesized that T2 relaxation magnetic resonance imaging (MRI) predicts the progression of perilesional cortical pathology and epileptogenesis. The ...

journal_title：Journal of neurotrauma

authors： Manninen E,Chary K,Lapinlampi N,Andrade P,Paananen T,Sierra A,Tohka J,Gröhn O,Pitkänen A

更新日期：2020-12-01 00:00:00

abstract：:The current lack of diagnostic and prognostic biomarkers for traumatic brain injury (TBI) confounds treatment and management of patients and is of increasing concern as the TBI population grows. We have generated plasma proteomic profiles from mice receiving TBI by controlled cortical impact at either 1.3 mm or 1.8 mm...

journal_title：Journal of neurotrauma

authors： Crawford F,Crynen G,Reed J,Mouzon B,Bishop A,Katz B,Ferguson S,Phillips J,Ganapathi V,Mathura V,Roses A,Mullan M

更新日期：2012-01-20 00:00:00

abstract：:A hallmark of the progressive cascade of damage referred to as secondary spinal cord injury (SCI) is vascular disruption resulting in decreased oxygen delivery and loss of mitochondria homeostasis. While therapeutics targeting restoration of single facets of mitochondrial function have proven largely ineffective clini...

journal_title：Journal of neurotrauma

authors： Scholpa NE,Williams H,Wang W,Corum D,Narang A,Tomlinson S,Sullivan PG,Rabchevsky AG,Schnellmann RG

更新日期：2019-03-19 00:00:00