Abstract：
:Cultured mammalian cells are the main workhorses for producing biologics. The performance of these cell culture processes, in terms of both productivity and product quality attributes, is significantly influenced by cellular metabolism. Glucose is the major carbon source for cellular biosynthesis and energy generation. We summarize here recent advances in our understanding of the regulation of glucose metabolism in cultured cells. The versatility of cells to sustain homeostatic states under widely varying environments is made possible by allosteric regulation of the metabolic network, interplay between the signaling pathways, and transcription factors. Understanding the regulation of metabolism holds the key to altering the metabolic regulatory circuit and implementing direct metabolic control over cell culture processes.
journal_name
Trends Biotechnoljournal_title
Trends in biotechnologyauthors
Mulukutla BC,Yongky A,Le T,Mashek DG,Hu WSdoi
10.1016/j.tibtech.2016.04.012subject
Has Abstractpub_date
2016-08-01 00:00:00pages
638-651issue
8eissn
0167-7799issn
1879-3096pii
S0167-7799(16)30031-2journal_volume
34pub_type
杂志文章,评审abstract：:Nature's most potent molecules are produced by enzyme-catalysed reactions, coupled with the natural selection of those products that possess optimal biological activity. Combinatorial biocatalysis harnesses the natural diversity of enzymatic reactions for the iterative synthesis of organic libraries. Iterative reactio...
journal_title：Trends in biotechnology
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abstract：:Are current docking methods capable of building complexes from putative component protein structures? Results of recent computational studies, including those of the CAPRI (Critical Assessment of Protein Interactions) competition, were used to determine the key properties for successful docking and introduce a classif...
journal_title：Trends in biotechnology
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journal_title：Trends in biotechnology
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