Neoadjuvant chemotherapy and chemotherapy cycle number: A national multicentre study.


OBJECTIVES:Six cycles of consolidation chemotherapy have become the standard for ovarian cancer treatment regimen following primary cytoreduction, yet with neoadjuvant chemotherapy (NAC), only 3 consolidation cycles are used. This study examines the effects of number of chemotherapy cycles in women with ovarian cancer that are being treated with neoadjuvant chemotherapy. In addition, we examined the effect of number of cycles on survival on consolidation and total chemotherapy. METHODS:All patients with stage IIIC and IV high grade serous carcinoma (HGSC) were identified at 4 major Canadian cancer centers treated with NAC. A retrospective chart review was conducted using the medical charts and registry databases. RESULTS:403 NAC patients were identified. 47% had zero residual disease. Chemotherapy cycles were divided into <3cycles or ≥4cycles for NAC and consolidation treatments and analyzed with multivariate analysis. 139/403 (34.5%) received ≥4cycles of NAC and had a worse prognosis than <3cycles (p=0.011). 70/403 (17.4%) received ≥4cycles of consolidation treatment and there was no difference in survival (p=0.33) CONCLUSION: Women with advanced HGSC are managed with a combination of surgery and chemotherapy. This is a study of a homogenous cohort of patients with stage IIIC or IV high grade serous cancers who received NAC. ≥4cycles of NAC had a worse outcome than <3cycles likely due to poor prognostic factors or poor response. The number of consolidation cycles did not appear to make a difference in overall survival.


Gynecol Oncol


Gynecologic oncology


Altman AD,McGee J,May T,Lane K,Lu L,Xu W,Ghatage P,Rosen B




Has Abstract


2017-11-01 00:00:00














  • Stage I uterine carcinosarcoma: Matched cohort analyses for lymphadenectomy, chemotherapy, and brachytherapy.

    abstract:OBJECTIVE:To determine if lymphadenectomy, chemotherapy and radiotherapy are associated with survival benefit among women with stage I uterine carcinosarcoma. METHODS:Women with stage I uterine carcinosarcoma (n=5614) were identified from the 1998-2013 National Cancer Data Base. Kaplan-Meier survival estimates and Cox...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Seagle BL,Kanis M,Kocherginsky M,Strauss JB,Shahabi S

    更新日期:2017-04-01 00:00:00

  • Effect of differentiation agents on expression of CA 125, alkaline phosphatase, and cytokeratins in human ovarian adenocarcinoma cells (OVCA 433).

    abstract::A number of chemical agents have been found to influence the proliferation, morphology, enzymatic activity, and antigen expression of neoplastic cells toward a more differentiated phenotype. We studied the effects of differentiating agents retinoic acid, sodium butyrate, and dibutyryl cyclic AMP on the expression of t...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Brooks SE,Timmerman J,Lau CC,Tsao SW,Knapp RC,Sheets EE

    更新日期:1991-09-01 00:00:00

  • Radical hysterectomy followed by tailored postoperative therapy in the treatment of stage IB2 cervical cancer: feasibility and indications for adjuvant therapy.

    abstract:OBJECTIVE:To determine the outcome, complications and likelihood of requiring adjuvant therapy of patients with stage IB2 cervical cancer treated with primary radical hysterectomy and lymph node dissection. METHODS:Clinical and pathologic data between 1985 and 1999 were reviewed. Associations between clinical and path...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yessaian A,Magistris A,Burger RA,Monk BJ

    更新日期:2004-07-01 00:00:00

  • Endometrial adenocarcinoma: clinical outcome in 881 patients and analysis of 146 patients whose deaths were due to endometrial cancer.

    abstract::Throughout 1970-1975, 881 patients were treated at Departments I and II of Obstetrics and Gynecology, Helsinki University Central Hospital. They were treated mainly by using surgery and/or radiotherapy combined with adjuvant progestin therapy. The over-all uncorrected 5-year survival rate was 72.2% and corrected rate ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Tiitinen A,Forss M,Aho I,Vesterinen E,Nieminen U

    更新日期:1986-09-01 00:00:00

  • Thromboembolic events in patients with cervical carcinoma: Incidence and effect on survival.

    abstract:OBJECTIVES:The purpose of this study was to determine whether thromboembolic events (TE) in cervical cancer patients are associated with survival by comparing the survival of patients with and without thromboembolic events over a seven year period. METHODS:Utilizing a retrospective chart review we identified patients ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jacobson G,Lammli J,Zamba G,Hua L,Goodheart MJ

    更新日期:2009-05-01 00:00:00

  • Advanced ovarian carcinoma presenting with a cerebrovascular accident.

    abstract::Ovarian carcinoma usually presents in an indolent manner, most often nonspecifically with complaints of abdominal pain or swelling, bloating, constipation, anorexia, early satiety, and evidence of ascites. We present a case of ovarian cancer with a cerebrovascular accident (CVA) as the presenting symptom, with minimal...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Shamonki MI,Squatrito RC,Welander CE

    更新日期:1998-08-01 00:00:00

  • Prognostic implications of histological tumor regression (Böhm's score) in patients receiving neoadjuvant chemotherapy for high grade serous tubal & ovarian carcinoma.

    abstract:OBJECTIVE:Primary objective of this study was to determine prognostic significance of Bohm's histopathological regression score in patients who received neoadjuvant chemotherapy (NACT) for treatment of high grade serous (HGS) tubal & ovarian carcinoma. METHODS:This was a retrospective cohort study of patients who rece...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rajkumar S,Polson A,Nath R,Lane G,Sayasneh A,Jakes A,Begum S,Mehra G

    更新日期:2018-11-01 00:00:00

  • Radical hysterectomy for recurrent cervical cancer following radiation therapy.

    abstract::In patients with small central recurrences following radiation therapy for cervical cancer the surgeon may have to make a judgment as to when radical hysterectomy is preferable to exenteration. During the years 1968-1984 there were 21 radical hysterectomies performed at Memorial Sloan-Kettering Cancer Center for recur...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rubin SC,Hoskins WJ,Lewis JL Jr

    更新日期:1987-07-01 00:00:00

  • Comparison of different commercial methods for HPV detection in follow-up cytology after ASCUS/LSIL, prediction of CIN2-3 in follow up biopsies and spontaneous regression of CIN2-3.

    abstract:OBJECTIVE:Different Human Papilloma Virus (HPV) tests are currently used. An integrated comparison of the Amplicor, Cobas4800, PreTect HPV-Proofer and APTIMA HPV tests has not been done. METHODS:We compared the high-risk HPV detection power of these HPV tests in 528 consecutive population-based follow-up Liquid-Based ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Ovestad IT,Vennestrøm U,Andersen L,Gudlaugsson E,Munk AC,Malpica A,Feng W,Voorhorst F,Janssen EA,Baak JP

    更新日期:2011-11-01 00:00:00

  • Expression and localization of aquaporin-5 in the epithelial ovarian tumors.

    abstract:OBJECTIVE:To investigate the expression and localization of aquaporin-5 (AQP5) in epithelial ovarian tumors and its clinic significance. METHODS:The expression of AQP5 protein and mRNA in 65 cases epithelial ovarian tumors and 13 cases normal tissue were measured by immunohistochemical technique, Western blotting and ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Yang JH,Shi YF,Cheng Q,Deng L

    更新日期:2006-02-01 00:00:00

  • Increased risk of secondary uterine leiomyosarcoma in hereditary retinoblastoma.

    abstract:OBJECTIVE:In the US, second non-ocular malignancies are the primary cause of death in retinoblastoma survivors with the germline RB1 mutation. Soft tissue sarcomas are one of the most likely malignancies to pose a risk to these patients, with leiomyosarcoma (LMS) being the most common subtype. As our cohort is followed...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Francis JH,Kleinerman RA,Seddon JM,Abramson DH

    更新日期:2012-02-01 00:00:00

  • The haplotype of two FSHR polymorphisms in ovarian cancer--a potential role of ethnology in risk modification.

    abstract:OBJECTIVES:The precise role of gonadotropins in the carcinogenesis of epithelial ovarian cancer remains uncertain. Recently, the haplotype of two single nucleotide polymorphisms, Thr307Ala (rs6165) and Asn680Ser (rs6166), has been described as a risk factor for ovarian cancer in Chinese women. In this study we investig...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Heubner M,Riemann K,Otterbach F,Kimmig R,Kasimir-Bauer S,Siffert W,Wimberger P

    更新日期:2009-03-01 00:00:00

  • Effect of race/ethnicity on risk of complete and partial molar pregnancy after adjustment for age.

    abstract:OBJECTIVE:To quantify the effect of race/ethnicity on risk of complete and partial molar pregnancy. METHODS:We conducted a cross-sectional study including women who were followed for complete or partial mole and those who had a live singleton birth in a teaching hospital in the northeastern United States between 2000 ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Melamed A,Gockley AA,Joseph NT,Sun SY,Clapp MA,Goldstein DP,Berkowitz RS,Horowitz NS

    更新日期:2016-10-01 00:00:00

  • Altered HLA expression by metastatic cervical carcinoma cells as a factor in impaired immune surveillance.

    abstract::The altered expression of histocompatibility leukocyte antigens (HLA) in the development to cervical carcinoma suggests that tumor progression may be related to impaired recognition by host immune defense mechanisms. To investigate whether this phenomenon plays a role in the process of metastasis of cervical cancer, w...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Hilders CG,Munoz IM,Nooyen Y,Fleuren GJ

    更新日期:1995-06-01 00:00:00

  • Proteomic analysis of stage I endometrial cancer tissue: identification of proteins associated with oxidative processes and inflammation.

    abstract:OBJECTIVE:The present study aimed to identify differentially expressed proteins employing a high resolution mass spectrometry (MS)-based proteomic analysis of endometrial cancer cells harvested using laser microdissection. METHODS:A differential MS-based proteomic analysis was conducted from discrete epithelial cell p...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Maxwell GL,Hood BL,Day R,Chandran U,Kirchner D,Kolli VS,Bateman NW,Allard J,Miller C,Sun M,Flint MS,Zahn C,Oliver J,Banerjee S,Litzi T,Parwani A,Sandburg G,Rose S,Becich MJ,Berchuck A,Kohn E,Risinger JI,Conrad

    更新日期:2011-06-01 00:00:00

  • Malignant struma ovarii: recurrence and response to treatment monitored by thyroglobulin levels.

    abstract::A patient with malignant struma ovarii who had elevated thyroglobulin levels at the time of her original surgery was diagnosed with recurrence on the basis of progressive thyroglobulin level elevation while on thyroid suppressive therapy. Subsequent treatment with therapeutic doses of iodine-137 resulted in normalizat...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Rose PG,Arafah B,Abdul-Karim FW

    更新日期:1998-09-01 00:00:00

  • Para-aortic lymphadenectomy may improve disease-related survival in patients with multipositive pelvic lymph node stage IIIc endometrial cancer.

    abstract:OBJECTIVE:The purpose of this study was to determine whether para-aortic lymphadenectomy improves disease-related survival (DRS) in stage IIIc endometrial cancer. METHODS:A total of 63 patients with stage IIIc endometrial carcinoma underwent primary radical surgery in the Tohoku Gynecologic Cancer Unit from 1993 to 20...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Fujimoto T,Nanjyo H,Nakamura A,Yokoyama Y,Takano T,Shoji T,Nakahara K,Yamada H,Mizunuma H,Yaegashi N,Sugiyama T,Kurachi H,Sato A,Tanaka T

    更新日期:2007-11-01 00:00:00

  • How accurate is frozen section histology of pelvic lymph nodes in patients with endometrial cancer?

    abstract:OBJECTIVE:Recent prospective data support the trend towards systematic retroperitoneal lymphadenectomy in patients with high-risk endometrial cancer. Because para-aortic node involvement in the absence of pelvic node involvement is uncommon, a reliable finding of negative pelvic lymph nodes (PLN) at intraoperative froz...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Pristauz G,Bader AA,Regitnig P,Haas J,Winter R,Tamussino K

    更新日期:2009-10-01 00:00:00

  • Comparison of long-term survival of total abdominal radical hysterectomy and laparoscopy-assisted radical vaginal hysterectomy in patients with early cervical cancer: Korean multicenter, retrospective analysis.

    abstract:PURPOSE:The aim of this study was to compare survival outcomes of total abdominal radical hysterectomy (TARH) versus laparoscopy-assisted radical vaginal hysterectomy (LARVH) in stage IA2-IB2 cervical cancer. METHODS:812 patients who underwent RH between 2008 and 2017 were evaluated in 3 institutions. Progression-free...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Kwon BS,Roh HJ,Lee S,Yang J,Song YJ,Lee SH,Kim KH,Suh DS

    更新日期:2020-12-01 00:00:00

  • Preoperative pathologic findings associated with residual disease at radical hysterectomy in women with stage IA2 cervical cancer.

    abstract:OBJECTIVE:To correlate findings on pathologic examination of loop electroexcisional procedure (LEEP) or cone biopsy specimens with residual disease in radical hysterectomy specimens in patients with stage IA2 cervical cancer to determine whether a subset of such patients may be eligible for conservative, fertility-spar...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Suri A,Frumovitz M,Milam MR,dos Reis R,Ramirez PT

    更新日期:2009-01-01 00:00:00

  • Endometrial cancer presentation is associated with social determinants of health in a public healthcare system: A population-based cohort study.

    abstract:OBJECTIVE:Delay in diagnosis of endometrial cancer may be associated with disease progression and impact management and outcomes. Social and cultural barriers influence recognition of symptoms and self-advocacy in seeking care. Associations between social determinants of health (SDH) and disease presentation have been ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Helpman L,Pond GR,Elit L,Anderson LN,Seow H

    更新日期:2020-07-01 00:00:00

  • Determinants of response to a cisplatin-based regimen as neoadjuvant chemotherapy in stage IB-IIB invasive cervical cancer.

    abstract::The response rate and the determinants of response to a cisplatin-based regimen of neodjuvant chemotherapy (NACT) in women with a histologically confirmed first-diagnosis of invasive bulky stage IB-IIB cervical cancer are analyzed. A total of 79 cases were treated with cisplatin (40 mg/m2) each 7 days for seven course...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Bolis G,van Zainten-Przybysz I,Scarfone G,Zanaboni F,Scarabelli C,Tateo S,Calabrese M,Parazzini F

    更新日期:1996-10-01 00:00:00

  • Elevated nm23 protein expression is correlated with diminished progression-free survival in patients with epithelial ovarian carcinoma.

    abstract:OBJECTIVES:The role of the candidate metastasis-suppressor gene nm23-H1 first characterized in breast cancer remains controversial, with both metastasis suppression and disease progression being linked to elevated nm23-H1 gene expression in different human tumor types. We sought to characterize (1) the pattern and inte...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Srivatsa PJ,Cliby WA,Keeney GL,Dodson MK,Suman VJ,Roche PC,Podratz KC

    更新日期:1996-03-01 00:00:00

  • Analysis of outcomes and prognostic factors after fertility-sparing surgery in malignant ovarian germ cell tumors.

    abstract:OBJECTIVE:To evaluate the oncologic and reproductive outcomes and to analyze prognostic factors after fertility-sparing surgery in patients with early and advanced malignant ovarian germ cell tumors (MOGCTs). METHODS:This study included 171 patients who underwent fertility-sparing surgery. Data were gathered from pati...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Park JY,Kim DY,Suh DS,Kim JH,Kim YM,Kim YT,Nam JH

    更新日期:2017-06-01 00:00:00

  • Correlation between LRIG1 and LRIG2 expressions and expression of 11 tumor markers, with special reference to tumor suppressors, in CIN and normal cervical epithelium.

    abstract:OBJECTIVE:Novel biological markers LRIG1 and LRIG2 have been associated with favorable as well as poor prognosis, respectively, in different cancer types, including cervical cancer. The aim of this study was to investigate possible interactions between these proteins and other tumor markers, and as diagnostic adjuncts ...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Lindström AK,Asplund A,Hellberg D

    更新日期:2011-08-01 00:00:00

  • Benign müllerian inclusions in pelvic and paraaortic lymph nodes.

    abstract:OBJECTIVE:This study was undertaken to determine the incidence and distribution of the location of benign müllerian inclusions in pelvic and paraaortic lymph nodes. METHODS:A total of 114 patients operated on for gynecologic malignancy between 1995 and 1998 underwent surgery including systematic pelvic (n = 114) or pe...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Reich O,Tamussino K,Haas J,Winter R

    更新日期:2000-08-01 00:00:00

  • Methotrexate-resistant mechanisms in human choriocarcinoma cells.

    abstract::Choriocarcinoma cells grown in the presence of methotrexate (MTX) developed resistance in two ways. HCCM-derived sublines (relatively high MTX resistance) produced enhanced levels of dihydrofolate reductase (DHFR) and had impaired transport of MTX. Altered transport was the primary determinant of response in CC1-deriv...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Sakai K,Wake N,Fujino T,Yasuda T,Kato H,Fujimoto S,Fujinaga K

    更新日期:1989-07-01 00:00:00

  • Incapacitating autonomic neuropathy precipitated by taxol.

    abstract::Taxol is one of the more significant advances in cancer chemotherapy in the last 10-15 years with a 30-50% response rate in both breast and ovarian cancers. The toxicity profile of taxol is still evolving as changes in the dosing and scheduling of the drug are instituted. We herein present the first evidence of taxol-...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Jerian SM,Sarosy GA,Link CJ Jr,Fingert HJ,Reed E,Kohn EC

    更新日期:1993-11-01 00:00:00

  • Prognostic factors for stage III epithelial ovarian cancer treated with intraperitoneal chemotherapy: a Gynecologic Oncology Group study.

    abstract:OBJECTIVES:To determine prognostic factors for survival in ovarian cancer patients treated with intraperitoneal (IP) chemotherapy using ancillary data from cooperative group clinical trials. METHODS:Data were collected from 428 patients with stage III ovarian cancer who underwent optimal surgical cytoreduction (<1 cm)...

    journal_title:Gynecologic oncology

    pub_type: 杂志文章


    authors: Landrum LM,Java J,Mathews CA,Lanneau GS Jr,Copeland LJ,Armstrong DK,Walker JL

    更新日期:2013-07-01 00:00:00

  • The effect of beta-adrenergic stimulation on the bladder and urethra following radical hysterectomy.

    abstract::The effect of two beta-adrenergic stimulating agents on bladder and urethral function was assessed in 16 patients 3 weeks after radical hysterectomy for carcinoma of the cervix. Urodynamic evaluation was performed before and after inhalation of metaproterenol by metered dose inhaler in 10 patients and injection of 0.2...

    journal_title:Gynecologic oncology

    pub_type: 临床试验,杂志文章


    authors: Kerr-Wilson RH,Orr JW Jr,Shingleton HM,Hatch KD,Trammel MW

    更新日期:1986-03-01 00:00:00