Mechanisms of transport of polymeric and lipidic nanoparticles across the intestinal barrier.

abstract：:The effective delivery of antigens via the oral route is an extremely desirable goal. Mucosal delivery of antigens stimulates mucosal and systemic immunity without affecting maternal antibodies and reduces the need for sterile needles or trained personnel. To date, there are very few commercially available oral vaccin...

journal_title：Advanced drug delivery reviews

authors： Foster N,Hirst BH

更新日期：2005-01-10 00:00:00

abstract：:Many drug molecules possess inadequate physical-chemical characteristics that prevent to surpass the viscous mucus layer present in the surface of mucosal tissues. Due to mucus protective role and its fast turnover, these drug molecules end up being removed from the body before being absorbed and, thus, before exertin...

journal_title：Advanced drug delivery reviews

authors： Araújo F,Martins C,Azevedo C,Sarmento B

更新日期：2018-01-15 00:00:00

abstract：:This paper reviews key issues found to affect acceptability and preferences for vaginal products to prevent HIV infection or HIV and pregnancy. We focus on the interplay between the biological and physico-chemical aspects of formulation and the social and behavioral issues that may affect use. The need for an HIV prev...

journal_title：Advanced drug delivery reviews

authors： Woodsong C,Holt JD

更新日期：2015-09-15 00:00:00

abstract：:Traditional anticancer therapies are often unable to completely eradicate the tumor bulk due to multi-drug resistance (MDR) of cancers. A number of mechanisms such as micro-environmental stress and overexpression of drug efflux pumps are involved in the MDR process. Hence, therapeutic strategies for overcoming MDR are...

journal_title：Advanced drug delivery reviews

authors： Zhou G,Latchoumanin O,Hebbard L,Duan W,Liddle C,George J,Qiao L

更新日期：2018-09-01 00:00:00

abstract：:A polymer stereocomplex is defined as a stereoselective interaction between two complementing stereoregular polymers, that interlock and form a new composite, demonstrating altered physical properties in comparison to the parent polymers. The main interactions, resulting in the complexation, are suggested to rely on s...

journal_title：Advanced drug delivery reviews

authors： Slager J,Domb AJ

更新日期：2003-04-25 00:00:00

abstract：:Modern pharmaceutical delivery systems are intended to produce plasma drug concentration versus time profiles that result in optimum therapeutic efficacy and a minimum of drug concentration-dependent adverse effects. To accomplish this requires that the drug delivery rate and temporal profile be based on the pharmacok...

journal_title：Advanced drug delivery reviews

authors： Levy G

更新日期：1998-09-07 00:00:00

abstract：:Synthetic polymer based Polyfectins (cationic polymer-DNA complex) have received intensive scientific research as they can potentially circumvent problems associated with viral vectors for gene therapy. These cationic macromolecules can readily condense DNA or RNA into stable nanostructures for use in gene delivery. R...

journal_title：Advanced drug delivery reviews

authors： Hunter AC

更新日期：2006-12-01 00:00:00

abstract：:Antibody-directed enzyme prodrug therapy (ADEPT) is a therapeutic strategy which aims to improve the selectivity of anticancer drugs. ADEPT is a two-step antibody targeting system that has benefits over a one-step chemo-, toxin- or radioimmunoconjugate. The basic principles of ADEPT are discussed alongside the require...

journal_title：Advanced drug delivery reviews

authors： Springer CJ,Niculescu-Duvaz I I

更新日期：1997-07-07 00:00:00

abstract：:Experimental and computational approaches to estimate solubility and permeability in discovery and development settings are described. In the discovery setting 'the rule of 5' predicts that poor absorption or permeation is more likely when there are more than 5 H-bond donors, 10 H-bond acceptors, the molecular weight ...

journal_title：Advanced drug delivery reviews

authors： Lipinski CA,Lombardo F,Dominy BW,Feeney PJ

更新日期：2001-03-01 00:00:00

abstract：:Microbubbles are used as ultrasonic contrast agents that enhance the ultrasound signals of the vascular bed. The recent development of site-targeted microbubbles opened up the possibility for molecular imaging as well as localised drug and gene delivery. Initially the microbubbles' physical properties and their respon...

journal_title：Advanced drug delivery reviews

authors： Sboros V

更新日期：2008-06-30 00:00:00

abstract：:A layer of mucus covers the surface of all wet epithelia throughout the human body. Mucus is a hydrogel mainly composed of water, mucins (glycoproteins), DNA, proteins, lipids, and cell debris. This complex composition yields a tenacious viscoelastic hydrogel that lubricates and protects the exposed epithelia from ext...

journal_title：Advanced drug delivery reviews

authors： Murgia X,Loretz B,Hartwig O,Hittinger M,Lehr CM

更新日期：2018-01-15 00:00:00

abstract：:The use of in silico tools within the drug development process to predict a wide range of properties including absorption, distribution, metabolism, elimination and toxicity has become increasingly important due to changes in legislation and both ethical and economic drivers to reduce animal testing. Whilst in silico ...

journal_title：Advanced drug delivery reviews

authors： Hewitt M,Ellison CM,Cronin MT,Pastor M,Steger-Hartmann T,Munoz-Muriendas J,Pognan F,Madden JC

更新日期：2015-06-23 00:00:00

abstract：:As the mainstay in the treatment of various cancers for several decades, chemotherapy is successful but still faces challenges including non-selectivity and high toxicity. Improving the selectivity is therefore a critical step to improve the therapeutic efficacy of chemotherapy. Prodrug is one of the most promising ap...

journal_title：Advanced drug delivery reviews

authors： Mahato R,Tai W,Cheng K

更新日期：2011-07-18 00:00:00

abstract：:The great interest in mucosal vaccine delivery arises from the fact that mucosal surfaces represent the major site of entry for many pathogens. Among other mucosal sites, nasal delivery is especially attractive for immunization, as the nasal epithelium is characterized by relatively high permeability, low enzymatic ac...

journal_title：Advanced drug delivery reviews

authors： Csaba N,Garcia-Fuentes M,Alonso MJ

更新日期：2009-02-27 00:00:00

abstract：:The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different collagen types identified so far. Collagens are centrally involved in the formatio...

journal_title：Advanced drug delivery reviews

authors： Gelse K,Pöschl E,Aigner T

更新日期：2003-11-28 00:00:00

abstract：:The extreme shortage of human donor organs for treatment of patients with end-stage organ failures is well known. Xenotransplantation, which might provide unlimited organ supply, is a most promising strategy to solve this problem. Domestic pigs are regarded as ideal organ-source animals owing to similarity in anatomy,...

journal_title：Advanced drug delivery reviews

authors： Niu D,Ma X,Yuan T,Niu Y,Xu Y,Sun Z,Ping Y,Li W,Zhang J,Wang T,Church GM

更新日期：2021-01-01 00:00:00

abstract：:Endogenous regenerative technology (Endoret) involves the use of patient's own biologically active proteins, growth factors and biomaterial scaffolds for therapeutic purposes. This technology provides a new approach for the stimulation and acceleration of tissue healing and bone regeneration. The versatility and bioco...

journal_title：Advanced drug delivery reviews

authors： Anitua E,Sánchez M,Orive G

更新日期：2010-06-15 00:00:00

abstract：:DNA plasmid-based gene expression systems are being widely investigated for the potential treatment of genetic and acquired disease and for DNA-based vaccination. A number of human clinical trials are in progress using plasmid-based drugs. The regulatory framework that has been applied to biologicals such as recombina...

journal_title：Advanced drug delivery reviews

authors： Eastman EM,Durland RH

更新日期：1998-03-02 00:00:00

abstract：:Gene delivery to bone is useful both as an experimental tool and as a potential therapeutic strategy. Among its advantages over protein delivery are the potential for directed, sustained and regulated expression of authentically processed, nascent proteins. Although no clinical trials have been initiated, there is a s...

journal_title：Advanced drug delivery reviews

authors： Evans CH

更新日期：2012-09-01 00:00:00

abstract：:The recent introduction of multi-photon microscopy coupled with advances in optics, computer sciences and the available fluorophores used to label molecules of interest have empowered investigators to study the dynamic events within the functioning kidney at cellular and subcellular levels. This emerging technique, wi...

journal_title：Advanced drug delivery reviews

authors： Molitoris BA,Sandoval RM

更新日期：2006-09-15 00:00:00

abstract：:Clinical pharmacogenomics, integrating genomic information with clinical practices to facilitate the prediction of drug response, has recently emerged as a vital area of public health. In clinical trials, phenotypic data on drug response are often longitudinal, with some patients dropping out early due to physiologica...

journal_title：Advanced drug delivery reviews

authors： Wang Z,Li H,Wang J,Li J,Wu R

更新日期：2013-06-30 00:00:00

abstract：:Amphiphilic polymers are particularly useful for drug delivery because of their ability to self-assemble into discrete aggregates. While this behavior has been studied in depth for simple linear block copolymer amphiphiles, recent advances in synthetic methodologies have provided efficient routes to amphiphilic polyme...

journal_title：Advanced drug delivery reviews

authors： Wang Y,Grayson SM

更新日期：2012-06-15 00:00:00

abstract：:With inhalational delivery the alveolar epithelium appears to be the appropriate lung surface to target for the systemic delivery of macromolecules, such as therapeutic proteins. The existence of a high numerical density of smooth-coated or non-coated plasma membrane vesicles or invaginations within the alveolar epith...

journal_title：Advanced drug delivery reviews

authors： Gumbleton M

更新日期：2001-07-28 00:00:00

abstract：:We have entered a new era in understanding CNS circuitry involved in acute and chronic pain. The ability to objectively measure a pain or analgesic state of the brain using non-invasive methods that define neural activation provides the possibility for top-down approaches to drug discovery. These brain maps represent ...

journal_title：Advanced drug delivery reviews

authors： Borsook D,Becerra L

更新日期：2003-08-28 00:00:00

abstract：:The composition and architecture of the stratum corneum render it a formidable barrier to the topical and transdermal administration of therapeutic agents. The physicochemical constraints severely limit the number of molecules that can be considered as realistic candidates for transdermal delivery. Iontophoresis provi...

journal_title：Advanced drug delivery reviews

authors： Kalia YN,Naik A,Garrison J,Guy RH

更新日期：2004-03-27 00:00:00

abstract：:An essential element of tissue homeostasis is the response to injuries, cutaneous wound healing being the most studied example. In the adults, wound healing aims at quickly restoring the barrier function of the skin, leading however to scar, a dysfunctional fibrotic tissue. On the other hand, in fetuses a scarless tis...

journal_title：Advanced drug delivery reviews

authors： Pratsinis H,Mavrogonatou E,Kletsas D

更新日期：2019-06-01 00:00:00

abstract：:Genome-editing tools such as Cre recombinase (Cre), zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and most recently the clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein system have revolutionized biomedical research, agriculture, microbial e...

journal_title：Advanced drug delivery reviews

authors： Li J,Røise JJ,He M,Das R,Murthy N

更新日期：2021-01-01 00:00:00

abstract：:Microemulsions are clear, stable, isotropic mixtures of oil, water and surfactant, frequently in combination with a cosurfactant. These systems are currently of interest to the pharmaceutical scientist because of their considerable potential to act as drug delivery vehicles by incorporating a wide range of drug molecu...

journal_title：Advanced drug delivery reviews

authors： Lawrence MJ,Rees GD

更新日期：2000-12-06 00:00:00

abstract：:Topical delivery to the various regions of the skin and underlying tissues, transdermal drug delivery and dermal exposure to environmental chemicals are important areas of research. Mathematical models of epidermal and dermal transport, involving penetration of a solute through various layers of the skin, metabolism i...

journal_title：Advanced drug delivery reviews

authors： Anissimov YG,Jepps OG,Dancik Y,Roberts MS

更新日期：2013-02-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have been developed for a number of indications due to their regenerative and anti-inflammatory phenotypes and their utility is enhanced by the fact that allogeneic transplant is feasible with this cell type. Animal studies and early human cases indicate that this has the potential to be ...

journal_title：Advanced drug delivery reviews

authors： Rodgers K,Jadhav SS

更新日期：2018-01-01 00:00:00