Abstract:
:Traditional anticancer therapies are often unable to completely eradicate the tumor bulk due to multi-drug resistance (MDR) of cancers. A number of mechanisms such as micro-environmental stress and overexpression of drug efflux pumps are involved in the MDR process. Hence, therapeutic strategies for overcoming MDR are urgently needed to improve cancer treatment efficacy. Aptamers are short single-stranded oligonucleotides or peptides exhibiting unique three-dimensional structures and possess several unique advantages over conventional antibodies such as low immunogenicity and stronger tissue-penetration capacity. Aptamers targeting cancer-associated receptors have been explored to selectively deliver a therapeutic cargo (anticancer drugs, siRNAs, miRNAs and drug-carriers) to the intratumoral compartment where they can exert better tumor-killing effects. In this review, we summarize current knowledge of the multiple regulatory mechanisms of MDR, with a particular emphasis on aptamer-mediated novel therapeutic agents and strategies that seek to reversing MDR. The challenges associated with aptamer-based agents and approaches are also discussed.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Zhou G,Latchoumanin O,Hebbard L,Duan W,Liddle C,George J,Qiao Ldoi
10.1016/j.addr.2018.04.005subject
Has Abstractpub_date
2018-09-01 00:00:00pages
107-121eissn
0169-409Xissn
1872-8294pii
S0169-409X(18)30057-7journal_volume
134pub_type
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journal_title:Advanced drug delivery reviews
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