Abstract：
:Current treatment of human immunodeficiency virus type-1 (HIV-1) infection involves a combination of antiretroviral drugs (ARVs) that target different stages of the HIV-1 life cycle. This strategy is commonly referred to as highly active antiretroviral therapy (HAART) or combined antiretroviral therapy (cART). Membrane-associated drug transporters expressed ubiquitously in mammalian systems play a crucial role in modulating ARV disposition during HIV-1 infection. Members of the ATP-binding cassette (ABC) and solute carrier (SLC) transporter superfamilies have been shown to interact with ARVs, including those that are used as part of first-line treatment regimens. As a result, the functional expression of drug transporters can influence the distribution of ARVs at specific sites of infection. In addition, pathological factors related to HIV-1 infection and/or ARV therapy itself can alter transporter expression and activity, thus further contributing to changes in ARV disposition and the effectiveness of HAART. This review summarizes current knowledge on the role of drug transporters in regulating ARV transport in the context of HIV-1 infection.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Alam C,Whyte-Allman SK,Omeragic A,Bendayan Rdoi
10.1016/j.addr.2016.05.001subject
Has Abstractpub_date
2016-08-01 00:00:00pages
121-143eissn
0169-409Xissn
1872-8294pii
S0169-409X(16)30143-0journal_volume
103pub_type
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