Abstract:
:In recent years, drug development costs have soared, primarily due to the failure of preclinical animal and cell culture models, which do not directly translate to human physiology. Organ-on-a-chip (OOC) is a burgeoning technology with the potential to revolutionize disease modeling, drug discovery, and toxicology research by strengthening the relevance of culture-based models while reducing costly animal studies. Although OOC models can incorporate a variety of tissue sources, the most robust and relevant OOC models going forward will include stem cells. In this review, we will highlight the benefits of stem cells as a tissue source while considering current limitations to their complete and effective implementation into OOC models.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Wnorowski A,Yang H,Wu JCdoi
10.1016/j.addr.2018.06.001subject
Has Abstractpub_date
2019-02-01 00:00:00pages
3-11eissn
0169-409Xissn
1872-8294pii
S0169-409X(18)30132-7journal_volume
140pub_type
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