Oral insulin delivery.

abstract：:Posterior segment drug delivery challenges inherent in the treatment of many sight-threatening diseases have become increasingly apparent. Therapeutic interventions for ocular diseases such as neovascular retinopathies, inflammatory and/or infectious diseases may involve drug delivery to vitreoretinal targets. An impo...

journal_title：Advanced drug delivery reviews

authors： Duvvuri S,Rittenhouse KD,Mitra AK

更新日期：2005-12-13 00:00:00

abstract：:Analogues of luteinizing hormone-releasing hormone (LH-RH) have made possible new approaches to the treatment of some hormone-dependent cancers and diseases and conditions which result from inappropriate sex hormone levels. In the fields of both gynaecology and oncology, the development of sustained delivery depot sys...

journal_title：Advanced drug delivery reviews

authors： Maria Comaru-Schally A,Schally AV

更新日期：1997-10-13 00:00:00

abstract：:Most antifolate drugs are efficiently transported by the reduced-folate carrier (RFC). However, several also bind with high affinity to the alpha-isoform of the folate receptor (alpha-FR) and there is evidence to suggest that this transport mechanism may contribute to their activity when the receptor is highly overexp...

journal_title：Advanced drug delivery reviews

authors： Jackman AL,Theti DS,Gibbs DD

更新日期：2004-04-29 00:00:00

abstract：:Gene and antisense/ribozyme therapy possesses tremendous potential for the successful treatment of genetically based diseases, such as cancer. Several cancer gene therapy strategies have already been realized in vitro, as well as in vivo. A few have even reached the stage of clinical trials, most of them phase I, whil...

journal_title：Advanced drug delivery reviews

authors： Merdan T,Kopecek J,Kissel T

更新日期：2002-09-13 00:00:00

abstract：:Poly(ortho esters), POE, are synthetic bioerodible polymers that can be prepared as solid materials, or as viscous, injectable polymers. These materials have evolved through a number of families, and the latest member of this family, POE IV, is particularly well suited to drug delivery since latent acid is integrated ...

journal_title：Advanced drug delivery reviews

authors： Barr J,Woodburn KW,Ng SY,Shen HR,Heller J

更新日期：2002-10-16 00:00:00

abstract：:Novel drug delivery systems based on microtechnology have advanced tremendously, but yet face some technological and societal hurdles to fully achieve their potential. The novel drug delivery systems aim to deliver drugs in a spatiotemporal- and dosage-controlled manner with a goal to address the unmet medical needs f...

journal_title：Advanced drug delivery reviews

authors： Lee HJ,Choi N,Yoon ES,Cho IJ

更新日期：2018-03-15 00:00:00

abstract：:Recent pre-clinical and clinical studies have shown that stem cell-based therapies hold tremendous promise for the treatment of human disease. Mesenchymal stem cells (MSC) are emerging as promising anti-cancer agents which have an enormous potential to be utilized to treat a number of different cancer types. MSC have ...

journal_title：Advanced drug delivery reviews

authors： Shah K

更新日期：2012-06-01 00:00:00

abstract：:The mammalian immune system has evolved mechanisms to recognize and respond to 'danger' signals arising from pathogens. Among those danger signals are the unmethylated CpG dinucleotide motifs found in bacteria. At least some of the recognition of these sequences is through cellular components of the innate immune syst...

journal_title：Advanced drug delivery reviews

authors： Scheule RK

更新日期：2000-11-15 00:00:00

abstract：:Antibodies can have exquisite specificity of target recognition and thus generate highly selective outcomes following their systemic administration. While antibodies can have high specificity, the doses required to treat patients, particularly for a chronic condition, are typically large. Fortunately, advances in prod...

journal_title：Advanced drug delivery reviews

authors： Daugherty AL,Mrsny RJ

更新日期：2006-08-07 00:00:00

abstract：:This article reviews the studies on skin electroporation carried out in vivo in animals and emphasizes its potential therapeutic applications for transdermal and topical drug delivery. In agreement with in vitro studies, transport across skin due to high-voltage pulses in vivo was shown to increase by orders of magnit...

journal_title：Advanced drug delivery reviews

authors： Vanbever R,Préat V V

更新日期：1999-01-04 00:00:00

abstract：:Tip-enhanced Raman scattering (TERS) has become a powerful tool for nanoscale structural analysis for several branches of organic, inorganic, and biological chemistry. This highly sensitive technique enables molecular characterization with a lateral resolution far beyond Abbe's diffraction limit and correlates structu...

journal_title：Advanced drug delivery reviews

authors： Sharma G,Deckert-Gaudig T,Deckert V

更新日期：2015-07-15 00:00:00

abstract：:Chronic wounding as a result of recurrent skin blistering in the painful genetic skin disease epidermolysis bullosa, may lead to life-threatening infections, increased risk of tumor formation, and other serious medical complications. Therefore, epidermolysis bullosa patients have an urgent need for optimal wound care ...

journal_title：Advanced drug delivery reviews

authors： Peking P,Koller U,Murauer EM

更新日期：2018-04-01 00:00:00

abstract：:Platinum based anticancer drugs have revolutionized cancer chemotherapy, and continue to be in widespread clinical use especially for management of tumors of the ovary, testes, and the head and neck. However, several dose limiting toxicities associated with platinum drug use, partial anti-tumor response in most patien...

journal_title：Advanced drug delivery reviews

authors： Oberoi HS,Nukolova NV,Kabanov AV,Bronich TK

更新日期：2013-11-01 00:00:00

abstract：:Infectious diseases are prevalent in the developing world and are one of the developing world's major sources of morbidity and mortality. While infectious diseases can initiate in a localized region, they can spread rapidly at any moment due to the ease of traveling from one part of the world to the next. This could l...

journal_title：Advanced drug delivery reviews

authors： Hauck TS,Giri S,Gao Y,Chan WC

更新日期：2010-03-18 00:00:00

abstract：:Despite advances in medicine and biomedical sciences, cancer still remains a major health issue. Complex interactions between tumors and their microenvironment contribute to tumor initiation and progression and also contribute to the development of drug resistant tumor cell populations. The complexity and heterogeneit...

journal_title：Advanced drug delivery reviews

authors： Sung KE,Beebe DJ

更新日期：2014-12-15 00:00:00

abstract：:Amphiphilic polymers are particularly useful for drug delivery because of their ability to self-assemble into discrete aggregates. While this behavior has been studied in depth for simple linear block copolymer amphiphiles, recent advances in synthetic methodologies have provided efficient routes to amphiphilic polyme...

journal_title：Advanced drug delivery reviews

authors： Wang Y,Grayson SM

更新日期：2012-06-15 00:00:00

abstract：:Spray drying is a well-established manufacturing technique which can be used to formulate amorphous solid dispersions (ASDs) which is an effective strategy to deliver poorly water soluble drugs (PWSDs). However, the inherently complex nature of the spray drying process coupled with specific characteristics of ASDs mak...

journal_title：Advanced drug delivery reviews

authors： Singh A,Van den Mooter G

更新日期：2016-05-01 00:00:00

abstract：:Over recent years the research focus within the field of respiratory drug delivery has broadened to include a wide range of potential applications for inhalation by delivering drugs not just onto the lung mucosa but across it. The range of drugs being assessed is broad and includes both current and novel therapies and...

journal_title：Advanced drug delivery reviews

authors： Cryan SA,Sivadas N,Garcia-Contreras L

更新日期：2007-09-30 00:00:00

abstract：:Antiepileptic drugs are commonly given orally for chronic treatment of epilepsy. The treatment of epilepsy requires administration of medications for both acute and chronic treatment using multiple types of formulations. Parenteral routes are used when the oral route is unavailable or a rapid clinical response is requ...

journal_title：Advanced drug delivery reviews

authors： Anderson GD,Saneto RP

更新日期：2012-07-01 00:00:00

abstract：:Several synthetic and natural materials are used in soft tissue engineering and regenerative medicine with varying degrees of success. Among them, silkworm silk protein fibroin, a naturally occurring protein-based biomaterial, exhibits many promising characteristics such as biocompatibility, controllable biodegradabil...

journal_title：Advanced drug delivery reviews

authors： Gholipourmalekabadi M,Sapru S,Samadikuchaksaraei A,Reis RL,Kaplan DL,Kundu SC

更新日期：2020-01-01 00:00:00

abstract：:Nuclear import of macromolecules or particles is a strictly regulated phenomenon that is now understood in some depth at the molecular level. Transport across nuclear membranes is controlled by nuclear pores, with the involvement of cytoplasmic receptors and accessory molecules. Each nuclear pore complex is an assembl...

journal_title：Advanced drug delivery reviews

authors： Pouton CW

更新日期：1998-10-05 00:00:00

abstract：:The selection of drug candidates early in development has become increasingly important to minimize the use of animals and to avoid costly failures of drugs later in development. In vitro systems to predict and assess organ toxicity have so far been of limited value due to difficulties in demonstrating in vivo-relevan...

journal_title：Advanced drug delivery reviews

authors： Roth A,Singer T

更新日期：2014-04-01 00:00:00

abstract：:Lack of approved pharmaceutical agents and/or pharmacokinetic data in the literature for exotic, wildlife, and zoo species is a major issue for veterinarians. These practitioners must take approved agents (veterinary or human) and extrapolate their use to non-approved species with little or no scientific basis to supp...

journal_title：Advanced drug delivery reviews

authors： Hunter RP,Isaza R

更新日期：2002-10-04 00:00:00

abstract：:Orally administered anti-HIV drugs must be adequately and consistently absorbed for therapy to be successful. This review discusses the barriers to achieving oral bioavailability for the currently available anti-HIV drugs. Most reverse transcriptase inhibitors have good oral bioavailabilities. Didanosine bioavailabili...

journal_title：Advanced drug delivery reviews

authors： Aungst BJ

更新日期：1999-10-18 00:00:00

abstract：:Nanotechnology has the potential to open many novel diagnostic and treatment avenues for disorders of the central nervous system (CNS). In this review, we discuss recent developments in the applications of nanotechnology in CNS therapies, diagnosis and biology. Novel approaches for the diagnosis and treatment of neuro...

journal_title：Advanced drug delivery reviews

authors： Smith ES,Porterfield JE,Kannan RM

更新日期：2019-08-01 00:00:00

abstract：:Many kinds of inorganic nanoparticles (NPs) including semiconductor, metal, metal oxide, and lanthanide-doped NPs have been developed for imaging and therapy applications. Their unique optical, magnetic, and electronic properties can be tailored by controlling the composition, size, shape, and structure. Interaction o...

journal_title：Advanced drug delivery reviews

authors： Nam J,Won N,Bang J,Jin H,Park J,Jung S,Jung S,Park Y,Kim S

更新日期：2013-05-01 00:00:00

abstract：:The administration of radiolabeled compounds with gamma-emitting radionuclides allows real time pursuit of in vivo behavior of the compounds by external counting of the radioactivity. If the compounds possess a specific localization mechanism to target tissue, the image reflects the specific function of the target. Th...

journal_title：Advanced drug delivery reviews

authors： Arano Y

更新日期：1999-04-05 00:00:00

abstract：:A wide range of polymeric scaffolds have been intensively studied for use as implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, mig...

journal_title：Advanced drug delivery reviews

authors： Chung HJ,Park TG

更新日期：2007-05-30 00:00:00

abstract：:Vaccines are one of the most powerful technologies supporting public health. The adaptive immune response induced by immunization arises following appropriate activation and differentiation of T and B cells in lymph nodes. Among many parameters impacting the resulting immune response, the presence of antigen and infla...

journal_title：Advanced drug delivery reviews

authors： Irvine DJ,Aung A,Silva M

更新日期：2020-01-01 00:00:00

abstract：:Hydrogels are synthetic or natural polymer networks that closely mimic native extracellular matrices. As hydrogel-based vehicles are being increasingly employed in therapeutic cell delivery, two inherent traits of most common hydrogels, namely low cell affinity and high cell constraint, have significantly drawn the at...

journal_title：Advanced drug delivery reviews

authors： Wang C,Varshney RR,Wang DA

更新日期：2010-06-15 00:00:00