Microfluidic 3D models of cancer.

Abstract:

:Despite advances in medicine and biomedical sciences, cancer still remains a major health issue. Complex interactions between tumors and their microenvironment contribute to tumor initiation and progression and also contribute to the development of drug resistant tumor cell populations. The complexity and heterogeneity of tumors and their microenvironment make it challenging to both study and treat cancer. Traditional animal cancer models and in vitro cancer models are limited in their ability to recapitulate human structures and functions, thus hindering the identification of appropriate drug targets and therapeutic strategies. The development and application of microfluidic 3D cancer models have the potential to overcome some of the limitations inherent to traditional models. This review summarizes the progress in microfluidic 3D cancer models, their benefits, and their broad application to basic cancer biology, drug screening, and drug discovery.

journal_name

Adv Drug Deliv Rev

authors

Sung KE,Beebe DJ

doi

10.1016/j.addr.2014.07.002

subject

Has Abstract

pub_date

2014-12-15 00:00:00

pages

68-78

eissn

0169-409X

issn

1872-8294

pii

S0169-409X(14)00143-4

journal_volume

79-80

pub_type

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