Drug encapsulated polymeric microspheres for intracranial tumor therapy: A review of the literature.

Abstract:

:Despite intensive surgical excision, radiation therapy, and chemotherapy, the current life expectancy for patients diagnosed with glioblastoma multiforme is only 12 to 15months. One of the approaches being explored to increase chemotherapeutic efficacy is to locally deliver chemotherapeutics encapsulated within degradable, polymeric microspheres. This review describes the techniques used to formulate drug encapsulated microspheres targeted for intracranial tumor therapy and how microsphere characteristics such as drug loading and encapsulation efficiency can be tuned based on formulation parameters. Further, the results of in vitro studies are discussed, detailing the varied drug release profiles obtained and validation of drug efficacy. Finally, in vivo results are summarized, highlighting the study design and the effectiveness of the drug encapsulated microspheres applied intracranially.

journal_name

Adv Drug Deliv Rev

authors

Floyd JA,Galperin A,Ratner BD

doi

10.1016/j.addr.2015.04.008

subject

Has Abstract

pub_date

2015-08-30 00:00:00

pages

23-37

eissn

0169-409X

issn

1872-8294

pii

S0169-409X(15)00064-2

journal_volume

91

pub_type

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