Abstract：
:Messenger RNA and small interfering RNA are attractive modalities for curing diseases by complementation or knock-down of proteins. For success of these RNAs, a drug delivery system (DDS) is required to control a pharmacokinetics, to enhance cellular uptake, to overcome biological membranes, and to release the cargo into the cytoplasm. Based on past research, developing nanoparticles that are neutrally charged have been the mainstream of their development. Also, the materials are further mounted with pH- and/or reducing environment-responsive units. In this review, we summarize progress made in the molecular design of these materials. We also focus on the importance of the hydrophobic scaffold for tissue/cell targeting, intracellular trafficking, and immune responses. As a practical example, the design concept of the SS-cleavable and pH-activated lipid-like material (ssPalm) and subsequent molecular modification tailored to the RNA-based medical application is discussed.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Tanaka H,Sakurai Y,Anindita J,Akita Hdoi
10.1016/j.addr.2020.07.001subject
Has Abstractpub_date
2020-01-01 00:00:00pages
210-226eissn
0169-409Xissn
1872-8294pii
S0169-409X(20)30077-6journal_volume
154-155pub_type
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