Abstract:
:When an artificial biomaterial (e.g., a stent or implantable pump) is exposed to blood, plasma proteins immediately adhere to the surface, creating a new interface between the biomaterial and the blood. The recognition proteins within the complement and contact activation/coagulation cascade systems of the blood will be bound to, or inserted into, this protein film and generate different mediators that will activate polymorphonuclear leukocytes and monocytes, as well as platelets. Under clinical conditions, the ultimate outcome of these processes may be thrombotic and inflammatory reactions, and consequently the composition and conformation of the proteins in the initial layer formed on the surface will to a large extent determine the outcome of a treatment involving the biomaterial, affecting both the functionality of the material and the patient's life quality. This review presents models of biomaterial-induced activation processes and describes various strategies to attenuate potential adverse reactions by conjugating bioactive molecules to surfaces or by introducing nanostructures.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Ekdahl KN,Lambris JD,Elwing H,Ricklin D,Nilsson PH,Teramura Y,Nicholls IA,Nilsson Bdoi
10.1016/j.addr.2011.06.012subject
Has Abstractpub_date
2011-09-16 00:00:00pages
1042-50issue
12eissn
0169-409Xissn
1872-8294pii
S0169-409X(11)00186-4journal_volume
63pub_type
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