Abstract：
:The blood-brain barrier (BBB) is a highly regulated and efficient barrier that provides a sanctuary to the brain. It is designed to regulate brain homeostasis and to permit selective transport of molecules that are essential for brain function. Unfortunately, drug transport to the brain is hampered by this almost impermeable, highly selective and well coordinated barrier. With progress in molecular biology, the BBB is better understood, particularly under different pathological conditions. This review will discuss the barrier issue from a biological and pathological perspective to provide a better insight to the challenges and opportunities associated with the BBB. Modern methods which can take advantage of these opportunities will be reviewed. Applications of nanotechnology in drug transport, receptor-mediated targeting and transport, and finally cell-mediated drug transport will also be covered in the review. The challenge of delivering an effective therapy to the brain is formidable; solutions will likely involve concerted multidisciplinary approaches that take into account BBB biology as well as the unique features associated with the pathological condition to be treated.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Chen Y,Liu Ldoi
10.1016/j.addr.2011.11.010subject
Has Abstractpub_date
2012-05-15 00:00:00pages
640-65issue
7eissn
0169-409Xissn
1872-8294pii
S0169-409X(11)00290-0journal_volume
64pub_type
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