Abstract：
:Bioprinted skin tissue has the potential for aiding drug screening, formulation development, clinical transplantation, chemical and cosmetic testing, as well as basic research. Limitations of conventional skin tissue engineering approaches have driven the development of biomimetic skin equivalent via 3D bioprinting. A key hope for bioprinting skin is the improved tissue authenticity over conventional skin equivalent construction, enabling the precise localization of multiple cell types and appendages within a construct. The printing of skin faces challenges broadly associated with general 3D bioprinting, including the selection of cell types and biomaterials, and additionally requires in vitro culture formats that allow for growth at an air-liquid interface. This paper provides a thorough review of current 3D bioprinting technologies used to engineer human skin constructs and presents the overall pipelines of designing a biomimetic artificial skin via 3D bioprinting from the design phase (i.e. pre-processing phase) through the tissue maturation phase (i.e. post-processing) and into final product evaluation for drug screening, development, and drug delivery applications.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Yan WC,Davoodi P,Vijayavenkataraman S,Tian Y,Ng WC,Fuh JYH,Robinson KS,Wang CHdoi
10.1016/j.addr.2018.07.016subject
Has Abstractpub_date
2018-07-01 00:00:00pages
270-295eissn
0169-409Xissn
1872-8294pii
S0169-409X(18)30182-0journal_volume
132pub_type
杂志文章,评审abstract：:While a vast array of liposomes, peptides, and molecular conjugates have been evaluated for nonviral gene transfer, the entity containing the actual gene itself is almost always a plasmid. The layout of most plasmid DNA (pDNA) vectors is usually quite simple, consisting of a promoter, transgene, polyadenylation signal...
journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
doi：10.1016/j.addr.2006.03.009
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
doi：10.1016/j.addr.2008.04.013
更新日期：2008-09-01 00:00:00
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
doi：10.1016/j.addr.2003.07.004
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
doi：10.1016/j.addr.2004.12.014
更新日期：2005-05-25 00:00:00
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
doi：10.1016/j.addr.2018.04.011
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
pub_type： 杂志文章,评审
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journal_title：Advanced drug delivery reviews
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journal_title：Advanced drug delivery reviews
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doi：10.1016/j.addr.2015.02.004
更新日期：2015-09-15 00:00:00
