Abstract:
:The development of lipid-based delivery vehicles for therapeutic molecules has become a topic of intense research. Recently, much of this effort has been directed towards mimicking the characteristics of viruses that give them an advantage for the delivery of genetic medicines. One of the most desirable properties of viral-based vectors is the ability to promote the destabilization of the host cell membrane to allow the entry of the genetic medicine into the target cell. This has been found to be largely controlled by the coat proteins on the surface of enveloped viruses. Although the exact mechanism by which proteins involved in the fusion process are able to promote the destabilization of membranes has yet to be elucidated, much understanding based upon information gained from a wide variety of studies is advancing the state of knowledge in this area. Parameters such as hydrophobic and electrostatic interactions as well as structural amphiphilicity, control to a large extent, the nature of the interaction of proteins with membranes. Thus, membrane fusion is mediated primarily by these forces acting in concert with one another. Ultimately, the knowledge gained from these studies will help to develop the ideal delivery system for the next generation of therapeutics.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Fujii Gdoi
10.1016/s0169-409x(99)00032-0subject
Has Abstractpub_date
1999-08-20 00:00:00pages
257-277issue
3eissn
0169-409Xissn
1872-8294pii
S0169-409X(99)00032-0journal_volume
38pub_type
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journal_title:Advanced drug delivery reviews
pub_type: 杂志文章,评审
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
pub_type: 杂志文章,评审
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
pub_type: 杂志文章,评审
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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pub_type: 杂志文章,评审
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journal_title:Advanced drug delivery reviews
pub_type: 杂志文章,评审
doi:10.1016/j.addr.2007.03.004
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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doi:10.1016/j.addr.2018.06.003
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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abstract::Transcutaneous immunization (TCI), the topical application of antigen and adjuvant directly onto intact skin, can safely and effectively elicit systemic immune responses in mice and humans against a variety of antigens. This novel method of vaccine delivery has the potential to provide a safe and convenient method by ...
journal_title:Advanced drug delivery reviews
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abstract::Nano- and microfabrication techniques have been widely explored in the textile, polymer and biomedical arenas, although more recently these systems have attracted considerable interest as drug delivery vehicles with concomitant considerations of physical characterization, scalability, stability and drug release. In th...
journal_title:Advanced drug delivery reviews
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doi:10.1016/j.addr.2016.01.003
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abstract::One of the most common causes of illnesses in humans is from respiratory tract infections caused by bacterial, viral or fungal pathogens. Inhaled anti-infective drugs are crucial for the prophylaxis and treatment of respiratory tract infections. The benefit of anti-infective drug delivery via inhalation is that it aff...
journal_title:Advanced drug delivery reviews
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journal_title:Advanced drug delivery reviews
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abstract::Diabetes mellitus (DM) ranks among the severest global health concerns of the 21st century. It encompasses a group of chronic disorders characterized by a dysregulated glucose metabolism, which arises as a consequence of progressive autoimmune destruction of pancreatic beta-cells (type 1 DM), or as a result of beta-ce...
journal_title:Advanced drug delivery reviews
pub_type: 杂志文章,评审
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