Abstract:
:Prior to the introduction of troglitazone, it had been more than 30 years since the last significant improvement in antidiabetic therapy. In view of the pressing need for more effective oral agents for the treatment of Type 2 diabetes mellitus, troglitazone was granted priority review by the FDA and was launched in the USA in 1997. The first of the thiazolidinedione insulin sensitizing agents, troglitazone was quickly followed by rosiglitazone and pioglitazone. The glitazones proved to be effective not only in lowering blood glucose, but also to have beneficial effects on cardiovascular risk. Troglitazone was subsequently withdrawn because of concerns about hepatotoxicity, which appears to be less of a problem with rosiglitazone and pioglitazone. Recent insights into the molecular mechanism of action of the glitazones, which are ligands for the peroxisome proliferator-activated receptors, open the prospect of designing more effective, selective and safer antidiabetic agents. This document will review the history of troglitazone from discovery through clinical development.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Parker JCdoi
10.1016/s0169-409x(02)00093-5subject
Has Abstractpub_date
2002-11-05 00:00:00pages
1173-97issue
9eissn
0169-409Xissn
1872-8294pii
S0169409X02000935journal_volume
54pub_type
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