Troglitazone: the discovery and development of a novel therapy for the treatment of Type 2 diabetes mellitus.

Abstract:

:Prior to the introduction of troglitazone, it had been more than 30 years since the last significant improvement in antidiabetic therapy. In view of the pressing need for more effective oral agents for the treatment of Type 2 diabetes mellitus, troglitazone was granted priority review by the FDA and was launched in the USA in 1997. The first of the thiazolidinedione insulin sensitizing agents, troglitazone was quickly followed by rosiglitazone and pioglitazone. The glitazones proved to be effective not only in lowering blood glucose, but also to have beneficial effects on cardiovascular risk. Troglitazone was subsequently withdrawn because of concerns about hepatotoxicity, which appears to be less of a problem with rosiglitazone and pioglitazone. Recent insights into the molecular mechanism of action of the glitazones, which are ligands for the peroxisome proliferator-activated receptors, open the prospect of designing more effective, selective and safer antidiabetic agents. This document will review the history of troglitazone from discovery through clinical development.

journal_name

Adv Drug Deliv Rev

authors

Parker JC

doi

10.1016/s0169-409x(02)00093-5

subject

Has Abstract

pub_date

2002-11-05 00:00:00

pages

1173-97

issue

9

eissn

0169-409X

issn

1872-8294

pii

S0169409X02000935

journal_volume

54

pub_type

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