Abstract：
:miRNA-based technologies provide attractive tools for several liver tissue engineering approaches. Herein, we review the current state of miRNA applications in liver tissue engineering. Several miRNAs have been implicated in hepatic disease and proper hepatocyte function. However, the clinical translation of these findings into tissue engineering has just begun. miRNAs have been successfully used to induce proliferation of mature hepatocytes and improve the differentiation of hepatic precursor cells. Nonetheless, miRNA-based approaches beyond cell generation have not yet entered preclinical or clinical investigations. Moreover, miRNA-based concepts for the biliary tree have yet to be developed. Further research on miRNA based modifications, however, holds the promise of enabling significant improvements to liver tissue engineering approaches due to their ability to regulate and fine-tune all biological processes relevant to hepatic tissue engineering, such as proliferation, differentiation, growth, and cell function.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Raschzok N,Sallmon H,Pratschke J,Sauer IMdoi
10.1016/j.addr.2015.06.005subject
Has Abstractpub_date
2015-07-01 00:00:00pages
67-77eissn
0169-409Xissn
1872-8294pii
S0169-409X(15)00117-9journal_volume
88pub_type
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