Abstract:
:Cytochrome P450 enzymes (CYPs) form one of the most important enzyme families involved in the metabolism of xenobiotics. CYPs comprise many isoforms, which catalyze a wide variety of reactions, and potentially, a large number of different metabolites can be formed. However, it is often hard to rationalize what metabolites these enzymes generate. In recent years, many different in silico approaches have been developed to predict binding or regioselective product formation for the different CYP isoforms. These comprise ligand-based methods that are trained on experimental CYP data and structure-based methods that consider how the substrate is oriented in the active site or/and how reactive the part of the substrate that is accessible to the heme group is. We will review key aspects for various approaches that are available to predict binding and site of metabolism (SOM), what outcome can be expected from the predictions, and how they could potentially be improved.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Olsen L,Oostenbrink C,Jørgensen FSdoi
10.1016/j.addr.2015.04.020subject
Has Abstractpub_date
2015-06-23 00:00:00pages
61-71eissn
0169-409Xissn
1872-8294pii
S0169-409X(15)00084-8journal_volume
86pub_type
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