Abstract:
:Drug failure due to toxicity indicators remains among the primary reasons for staggering drug attrition rates during clinical studies and post-marketing surveillance. Broader validation and use of next-generation 3-D improved cell culture models are expected to improve predictive power and effectiveness of drug toxicological predictions. However, after decades of promising research significant gaps remain in our collective ability to extract quality human toxicity information from in vitro data using 3-D cell and tissue models. Issues, challenges and future directions for the field to improve drug assay predictive power and reliability of 3-D models are reviewed.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Astashkina A,Grainger DWdoi
10.1016/j.addr.2014.02.008subject
Has Abstractpub_date
2014-04-01 00:00:00pages
1-18eissn
0169-409Xissn
1872-8294pii
S0169-409X(14)00030-1journal_volume
69-70pub_type
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