Abstract:
:Type 1 diabetes is an autoimmune disease marked by the destruction of insulin-producing beta cells in the pancreatic islets. Strategies to delay onset or prevent the autoimmune recognition of beta cell antigens or T cell-mediated killing of beta cells have mainly focused on systemic immunomodulation and antigen-specific immunotherapy. To bridge the fields of type 1 diabetes immunology and biomaterials engineering, this article will review recent trends in the etiology of type 1 diabetes immunopathology and will focus on the contributions of emerging bioengineered strategies in the fight against beta cell autoimmunity in type 1 diabetes.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Baekkeskov S,Hubbell JA,Phelps EAdoi
10.1016/j.addr.2017.06.007subject
Has Abstractpub_date
2017-05-15 00:00:00pages
256-265eissn
0169-409Xissn
1872-8294pii
S0169-409X(17)30091-1journal_volume
114pub_type
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