Potential Anticancer Mechanisms of a Novel EGFR/DNA-Targeting Combi-Molecule (JDF12) against DU145 Prostate Cancer Cells: An iTRAQ-Based Proteomic Analysis.

abstract：BACKGROUND:Inflammation has a key role in migraine pathophysiology. Vitamin D is an effective anti-inflammatory agent. The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache...

journal_title：BioMed research international

authors： Motaghi M,Haghjooy Javanmard S,Haghdoost F,Tajadini M,Saadatnia M,Rafiee L,Zandifar A

更新日期：2013-01-01 00:00:00

abstract：:Stimuli responsive pH- and temperature-sensitive hydrogel drug delivery systems, as those based on N-isopropylacrylamide (NiPAAm) and itaconic acid (IA), have been attracting much of the attention of the scientific community nowadays, especially in the field of drug release. By adjusting comonomer composition, the mat...

journal_title：BioMed research international

authors： Milašinović N,Knežević-Jugović Z,Milosavljević N,Lučić Škorić M,Filipović J,Kalagasidis Krušić M

更新日期：2014-01-01 00:00:00

abstract：:Polyetheretherketone (PEEK), which has biomechanical performance similar to that of human cancellous bone, is used widely as a spinal implant material. However, its bioinertness and hydrophobic surface properties result in poor osseointegration. This study applies a novel modification method, arc ion plating (AIP), th...

journal_title：BioMed research international

authors： Tsou HK,Chi MH,Hung YW,Chung CJ,He JL

更新日期：2015-01-01 00:00:00

abstract：:Ambient assisted living (AAL) aims to help older persons "age-in-place" and manage everyday activities using intelligent and pervasive computing technology. AAL research, however, has yet to explore how AAL might support or collaborate with informal care partners (ICPs), such as relatives and friends, who play importa...

journal_title：BioMed research international

authors： Hwang AS,Truong KN,Cameron JI,Lindqvist E,Nygård L,Mihailidis A

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To analyze the clinical relevance of the levels of TNFα blockers and anti-drug antibodies (anti-drug Ab) in patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) treated with adalimumab (ADA), etanercept (ETA), or infliximab (INF) for a prolonged period of time. METHODS:Clinical characteristics...

journal_title：BioMed research international

authors： Arstikyte I,Kapleryte G,Butrimiene I,Venalis A

更新日期：2015-01-01 00:00:00

abstract：AIM:To create a predictive score for the discrimination between benign and malignant parotid tumors using elastographic parameters and to compare its sensitivity and specificity with standard ultrasound. METHODS:A total of 124 patients with parotid gland lesions for whom surgery was planned were examined using convent...

journal_title：BioMed research international

authors： Heřman J,Sedláčková Z,Vachutka J,Fürst T,Salzman R,Vomáčka J,Heřman M

更新日期：2017-01-01 00:00:00

abstract：AIMS/INTRODUCTION:Determining the prevalence of diabetes and its cardiovascular complications and all-cause mortality in older chronic complex patients. MATERIALS AND METHODS:We carried out a multicenter retrospective study and included a randomized sample of 932 CCP people. We assessed the prevalence of diabetes acco...

journal_title：BioMed research international

authors： Clua-Espuny JL,González-Henares MA,Queralt-Tomas MLL,Campo-Tamayo W,Muria-Subirats E,Panisello-Tafalla A,Lucas-Noll J

更新日期：2017-01-01 00:00:00

abstract：:The study aimed to determine the suitability of testing the saliva of kickboxing athletes to show changes in biochemical parameters in dynamic of training. 8 elite male athletes (mean age 17.29± 0.31 years, body mass 66.82± 3.46kg, with 5.62±0.96 years of training experience) participated in the study. Indicators of l...

journal_title：BioMed research international

authors： Volodchenko OA,Podrigalo LV,Iermakov SS,Żychowska MT,Jagiełło W

更新日期：2019-01-10 00:00:00

abstract：:Exosomal miRNAs are currently being explored as a novel class of biomarkers in cardiovascular diseases. However, few reports have focused on the value of circulating exosomal miRNAs as biomarkers for stable coronary artery disease (SCAD). Here, we aimed to investigate whether miRNAs involved in cardiovascular diseases...

journal_title：BioMed research international

authors： Zhang P,Liang T,Chen Y,Wang X,Wu T,Xie Z,Luo J,Yu Y,Yu H

更新日期：2020-12-11 00:00:00

abstract：:Traumatic brain injury (TBI) is a critical public health and socioeconomic problem worldwide. The herb pair Astragali Radix (AR)-Radix Angelica Sinensis (RAS) is a common prescribed herbal formula or is added to other Chinese medicine prescriptions for traumatic brain injury (TBI) treatment. However, the underlying me...

journal_title：BioMed research international

authors： Xie G,Peng W,Li P,Xia Z,Zhong Y,He F,Tulake Y,Feng D,Wang Y,Xing Z

更新日期：2018-11-25 00:00:00

abstract：:Henoch-Schönlein purpura (HSP) is the most common systemic vasculitis in children, and renal involvement (HSP nephritis, HSPN) is a severe manifestation. HSPN is histologically classified by the International Study of Kidney Disease in Children (ISKDC) based on mesangial hypercellularity and the extent of glomerular c...

journal_title：BioMed research international

authors： Kim J,Choi SE,Lee KH,Jeong HJ,Shin JI,Lim BJ

更新日期：2019-01-20 00:00:00

abstract：:Metastasis is the leading cause of lung cancer-associated death. Downregulated expression of E-cadherin followed by epithelial-mesenchymal transition (EMT) is critical for metastasis initiation in lung cancer. BTBD7 plays essential roles in lung cancer metastasis, but the mechanisms remain unknown. This study aimed to...

journal_title：BioMed research international

authors： Shu J,Wang L,Han F,Chen Y,Wang S,Luo F

更新日期：2019-11-27 00:00:00

abstract：:Owing to its hydrophilicity, negative charge, small size, and labile degradation by endogenous nucleases, small interfering RNA (siRNA) delivery must be achieved by a carrier system. In this study, cationic copolymers composed of low-molecular-weight polyethylenimine and polythiophenes were synthesized and evaluated a...

journal_title：BioMed research international

authors： He P,Hagiwara K,Chong H,Yu HH,Ito Y

更新日期：2015-01-01 00:00:00

abstract：:Synovitis plays an important role in the pathogenesis of arthritis, which is closely related to the joint swell and pain of patients. The purpose of this study was to investigate the anti-inflammatory effects of pulsed electromagnetic fields (PEMF) on synovitis and its underlying mechanisms. Destabilization of the med...

journal_title：BioMed research international

authors： Ouyang J,Zhang B,Kuang L,Yang P,Du X,Qi H,Su N,Jin M,Yang J,Xie Y,Tan Q,Chen H,Chen S,Jiang W,Liu M,Luo X,He M,Ni Z,Chen L

更新日期：2020-05-26 00:00:00

abstract：Results:The VMAT plans showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, monitor units (MUs), and maximum dose (Dmax) to the contralateral breast compared with TSP and 9FIMRT plans. The TSP provided better protection for Dmean of the heart and left ventricle ...

journal_title：BioMed research international

authors： Hu J,Han G,Lei Y,Xu X,Ge W,Ruan C,Chang S,Zhang A,Li X

更新日期：2020-03-26 00:00:00

abstract：:Preeclampsia (PE) is a unique complication of pregnancy, the pathogenesis of which has been generally accepted to be associated with the dysfunctions of extravillous trophoblast (EVT) including proliferation, apoptosis, and migration and invasion. Decorin (DCN) has been proved to be a decidua-derived TGF-binding prote...

journal_title：BioMed research international

authors： Zou Y,Yu X,Lu J,Jiang Z,Zuo Q,Fan M,Huang S,Sun L

更新日期：2015-01-01 00:00:00

abstract：Purpose:The aim of this study is to evaluate the effectiveness of laboratory serum tests in the diagnosis of infected nonunion. Methods:Forty-two patients suspected of having infected nonunion were investigated in the study. The serum levels of white blood-cell count (WBC), C-reactive protein (CRP), erythrocyte sedime...

journal_title：BioMed research international

authors： Wang S,Yin P,Quan C,Khan K,Wang G,Wang L,Cui L,Zhang L,Zhang L,Tang P

更新日期：2017-01-01 00:00:00

abstract：:Acute leukemias are the most frequent childhood malignancies worldwide and remain a leading cause of morbidity and mortality of relapsed patients. While remarkable progress has been made in characterizing genetic aberrations that may control these hematological disorders, it has also become clear that abnormalities in...

journal_title：BioMed research international

authors： Dorantes-Acosta E,Vadillo E,Contreras-Quiroz A,Balandrán JC,Arriaga-Pizano L,Purizaca J,Huerta-Yepez S,Jiménez E,Aguilera W,Medina-Sanson A,Mayani H,Pelayo R

更新日期：2013-01-01 00:00:00

abstract：:The potential of three submerged aquatic plant species (Cabomba piauhyensis, Egeria densa, and Hydrilla verticillata) to be used for As, Al, and Zn phytoremediation was tested. The plants were exposed for 14 days under hydroponic conditions to mine waste water effluents in order to assess the suitability of the aquati...

journal_title：BioMed research international

authors： Abu Bakar AF,Yusoff I,Fatt NT,Othman F,Ashraf MA

更新日期：2013-01-01 00:00:00

abstract：:In preclinical treatment of polytraumatized patients crystalloids are preferentially used. To avoid metabolic acidosis, metabolizable anions like lactate or acetate are used to replace chloride in these solutions. We here studied the effects of malated Ringer's in resuscitation of both shock severities in comparison t...

journal_title：BioMed research international

authors： Keitel J,Hussmann B,Lendemans S,de Groot H,Rohrig R

更新日期：2015-01-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) has a significant clinical relevance of being associated with a shorter median time to relapse and death and does not respond to endocrine therapy or other available targeted agents. Increased aggressiveness of this tumor, as well as resistance to standard drug therapies, may be as...

journal_title：BioMed research international

authors： Collina F,Di Bonito M,Li Bergolis V,De Laurentiis M,Vitagliano C,Cerrone M,Nuzzo F,Cantile M,Botti G

更新日期：2015-01-01 00:00:00

abstract：:Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...

journal_title：BioMed research international

authors： Schaller A,Rudolf K,Dejonghe L,Grieben C,Froboese I

更新日期：2016-01-01 00:00:00

abstract：Background:Clinical trials based on FGFR mutation or amplification as a druggable target of FGFR inhibitors have produced disappointing clinical outcomes. Therefore, the identification of predictive biomarkers for FGFR-targeted agents has remained a crucial issue. Methods:Expression profiles of FGFs and FGFRs in 8,111...

journal_title：BioMed research international

authors： Li Y,Wu L,Tao W,Wu D,Ma F,Li N

更新日期：2020-06-03 00:00:00

abstract：:Interactions between proteins and drugs, which can lead to formation of stable drug-protein complexes, have important implications on several processes related to human health. These interactions can affect, for instance, free concentration, biological activity, and metabolism of the drugs in the blood stream. Here, w...

journal_title：BioMed research international

authors： Gorza FD,Pedro GC,Trescher TF,da Silva RJ,Silva JR,de Souza NC

更新日期：2014-01-01 00:00:00

abstract：:Background. High HDL-cholesterol (HDL-C) values are negatively correlated with cardiovascular diseases. This review analyses the effect of the supplementation with various Mediterranean diet products (artichoke, bergamot, and olive oil) and Asian diet products (red yeast rice) on the HDL-C value in dyslipidemic subjec...

journal_title：BioMed research international

authors： Rondanelli M,Giacosa A,Morazzoni P,Guido D,Grassi M,Morandi G,Bologna C,Riva A,Allegrini P,Perna S

更新日期：2016-01-01 00:00:00

abstract：:We aim to investigate the effects of curcumin on preventing diabetes-induced vascular inflammation in association with its actions on Txnip, ICAM-1, and NOX2 enzyme expressions. Male Wistar rats were divided into four groups: control (CON), diabetic (DM; streptozotocin (STZ), i.v. 55 mg/kg BW), control-treated with cu...

journal_title：BioMed research international

authors： Wongeakin N,Bhattarakosol P,Patumraj S

更新日期：2014-01-01 00:00:00

abstract：:This study was conducted to show the effect of Aspergillus awamori (AA), fructooligosaccharide (FOS), and combined Aspergillus awamori and fructooligosaccharide (AA + FOS) on growth, digestibility, blood parameters, and expression of some growth-related genes. A total of 60 broiler chicks at the age of 15 d were divid...

journal_title：BioMed research international

authors： Saleh AA,Amber K,El-Magd MA,Atta MS,Mohammed AA,Ragab MM,Abd El-Kader H

更新日期：2014-01-01 00:00:00

abstract：:Family planning coverage has improved in Ethiopia in the last decade, though fertility is still about 5.8 in the rural setup. In this paper, the major structural determinants of family planning service were analyzed using a multilevel model from 8906 individual women observation in the 2011 EDHS data. The results show...

journal_title：BioMed research international

authors： Gizachew Balew J,Cho Y,Tammy Kim C,Ko W

更新日期：2015-01-01 00:00:00

abstract：:The distribution of the induced electric field (E-field) during transcranial magnetic stimulation (TMS) depends on the individual anatomical structure of the brain as well as coil positioning. Inappropriate stimulation may degrade the efficacy of TMS or even induce adverse effects. Therefore, optimizing the E-field ac...

journal_title：BioMed research international

authors： Li C,Liu C,Yang L,He L,Wu T

更新日期：2019-11-03 00:00:00

abstract：:This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitin...

journal_title：BioMed research international

authors： Lee JH,Kim SJ,Park SI,Ko YG,Choi D,Hong MK,Jang Y

更新日期：2016-01-01 00:00:00