Age-associated changes in glutamine synthetase activity in WI-38 cells.

abstract：:Normal diploid Syrian hamster dermal mesenchymal cell strains, regardless of the age of the tissue of origin, exhibit in vitro cellular senescence. The frequency of spontaneous escape from senescence and conversion to a permanent cell line is less than 5% among replicate flasks. The overall pattern of senescence of ce...

journal_title：Mechanisms of ageing and development

authors： Bruce SA,Deamond SF,Ts'o PO

更新日期：1986-04-01 00:00:00

abstract：:The identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural characteristics were investigated in ICR-CD1 female mice at the adult age (N...

journal_title：Mechanisms of ageing and development

authors： Martínez de Toda I,Vida C,Sanz San Miguel L,De la Fuente M

更新日期：2019-09-01 00:00:00

abstract：:In this article we review the abnormalities in immune function which have been described in relation to ageing. It is suggested that thymic involution may not be the only underlying cause. Many similar changes can be induced by the endotoxins from the cell walls of Gram-negative bacteria. The colon is a large reposito...

journal_title：Mechanisms of ageing and development

authors： Horan MA,Fox RA

更新日期：1984-08-01 00:00:00

abstract：:Compelling evidence supports the importance of metabolic abnormalities in Alzheimer disease pathogenesis. Indeed, that oxidative mechanisms are involved in the neuropathology associated with Alzheimer disease is evidenced by the large number of metabolic signs of oxidative stress as well as by specific markers of oxid...

journal_title：Mechanisms of ageing and development

authors： Moreira PI,Zhu X,Lee HG,Honda K,Smith MA,Perry G

更新日期：2006-06-01 00:00:00

abstract：:This study has characterised the time course of two major transcriptional adaptive responses to exercise (changes in antioxidant defence enzyme activity and heat shock protein (HSP) content) in muscles of adult and old male mice following isometric contractions and has examined the mechanisms involved in the age-relat...

journal_title：Mechanisms of ageing and development

authors： Vasilaki A,McArdle F,Iwanejko LM,McArdle A

更新日期：2006-11-01 00:00:00

abstract：:Age-specific mortality rates from breast cancer (BC) in Japan from 1950 through 1993 were subjected to longitudinal Gompertzian and Weibull analyses. Age-specific BC mortality rate distributions between the ages of 30 and 75 years were Gompertzian in each year. Between 1950 and 1993, age-adjusted BC mortality rates in...

journal_title：Mechanisms of ageing and development

authors： Imaizumi Y

更新日期：1996-07-17 00:00:00

abstract：:Lipofuscin-specific autofluorescence of living, cultured rat neonatal myocardial myocytes was studied with respect to intensity and spectral characteristics. The autofluorescence emission spectrum changed over time indicating continuously ongoing intramolecular reorganisation of the pigment. Moreover, as compared with...

journal_title：Mechanisms of ageing and development

authors： Gao G,Johansson U,Rundquist I,Ollinger K

更新日期：1994-01-01 00:00:00

abstract：:The age-related changes in the distribution of enkephalin-immunoreactive (ENK-IR) nerve fibers in relation to the principal neurons were studied in 23 human sympathetic ganglia from patients aged between 22 and 98 years. There were no age-related changes in the diameter of nerve cells and the packing density of the ne...

journal_title：Mechanisms of ageing and development

authors： Järvi R,Helen P,Pelto-Huikko M,Rapoport SI,Hervonen A

更新日期：1988-08-01 00:00:00

abstract：:We have studied effects of long-term, low-dose growth hormone therapy on the immune function and life expectancy of Balb/c mice. Sixty male Balb/c mice were aged up to the time when they started showing signs of senescence and causal death (deaths started when they became 17 months old). The aged mice were divided int...

journal_title：Mechanisms of ageing and development

authors： Khansari DN,Gustad T

更新日期：1991-01-01 00:00:00

abstract：:The mTOR deregulation has a role in chronic kidney disease including diabetic nephropathy. SIRT1 is an important participant in renal cytoprotective responses to aging and stress. However, whether both mTOR and SIRT1 are involved in high glucose-inducing mesangial cells (MCs) senescence still remains to be explored. H...

journal_title：Mechanisms of ageing and development

authors： Zhang S,Cai G,Fu B,Feng Z,Ding R,Bai X,Liu W,Zhuo L,Sun L,Liu F,Chen X

更新日期：2012-06-01 00:00:00

abstract：:The functional deterioration of an organism with age causes the major problem of maintaining the quality of life at old age. Degenerative changes in the organism may to some extent reflect alterations that can be observed in cells during in vitro replicative senescence. At the cellular level, the receptor-mediated end...

journal_title：Mechanisms of ageing and development

authors： Park SC

更新日期：2002-04-30 00:00:00

abstract：:Amyloidosis refers to a group of protein folding diseases. Various innocuous and soluble proteins in physiological conditions polymerize to insoluble amyloid fibrils in several serious diseases, including Alzheimer's disease (AD) and prion diseases. In addition, senile amyloidosis is a form of amyloidosis in which the...

journal_title：Mechanisms of ageing and development

authors： Xing Y,Higuchi K

更新日期：2002-11-01 00:00:00

abstract：:The effect of life-long diets containing different concentrations of selenium and vitamin E on the age pigment accumulation in the rat superior cervical ganglion, vagal ganglion and dorsal root ganglion, was studied using microspectrofluorometry. All types of ganglia showed unchanged amounts of age pigments at low or ...

journal_title：Mechanisms of ageing and development

authors： Koistinaho J,Alho H,Hervonen A

更新日期：1990-01-01 00:00:00

abstract：:The plasma disappearance of endotoxin and endotoxin-induced hepatic injury were studied in two rat models: the aging rat and the subacutely hypervitaminotic A rat. The choice of these models was based on their respective association with a decreased or increased Kupffer cell endocytic activity. The half-life of endoto...

journal_title：Mechanisms of ageing and development

authors： Hendriks HF,Horan MA,Durham SK,Earnest DL,Brouwer A,Hollander CF,Knook DL

更新日期：1987-12-01 00:00:00

abstract：:Neutral endopeptidase 24.11 (NEP) inhibitors prevent breakdown of atrial natriuretic peptide (ANP), and may be useful therapeutically, in sodium overload states as often occurs in the aged. However, age-dependent changes in ANP/NEP may limit the activity of these agents in the elderly. To investigate this we conducted...

journal_title：Mechanisms of ageing and development

authors： Greenfeld Z,Engels K,Samsell L,Baylis C

更新日期：2001-09-01 00:00:00

abstract：:Chromosome analyses and Ig level determinations were carried out on seventeen aged men and women, 83--100 years of age. In men, significant correlations were found between hypodiploidy and IgA (gamma = 0.95) and between monosomy C and IgG (gamma = 0.79) while in women, monosomy G and IgG were significantly correlated ...

journal_title：Mechanisms of ageing and development

authors： Matsuyama SS,Cohen D,Jarvik LF

更新日期：1978-12-01 00:00:00

abstract：:The lipid peroxidation and activities of main enzymes involved in the peroxide metabolism were measured at resting conditions and after completion of a 2-month treatment with H2O2. At the start of the experiments 1- and 3-month-old female BALB/c mice received either a high dose of H2O2 (0.5% H2O2 in drinking water; in...

journal_title：Mechanisms of ageing and development

authors： Imre S,Tóth F,Fachet J

更新日期：1984-12-01 00:00:00

abstract：:As the endothelium ages it may become more susceptible to damage by atherogenic plasma components such as toxic lipid oxidation products. Vitamin E (vit E) might prove to be anti-atherogenic by reducing oxidative injury. This study investigated the effects of age and chronic exposure to fatty acid hydroperoxides (OFA)...

journal_title：Mechanisms of ageing and development

authors： Boissonneault GA,Hennig B,Wang Y,Wood CL

更新日期：1990-10-01 00:00:00

abstract：:To investigate the relationship between immunological potential and advance of age, patterns of humoral immune response in different aged rabbits were compared. In the primary response, the appearance of total antibody and the arrival to its peak level were retarded by advance of age. On the other hand, the appearance...

journal_title：Mechanisms of ageing and development

authors： Nomaguchi T,Okuma-Sakurai Y,Kimura I

更新日期：1976-01-01 00:00:00

abstract：:Population studies have demonstrated that telomere length (TL) displays great diversity among different populations. Previously described controversial findings associated longevity with specific mitochondrial DNA haplogroups (hgs) (e.g., J and U). These observations may be influenced by population diversity, geograph...

journal_title：Mechanisms of ageing and development

authors： Zole E,Elferts D,Kimsis J,Krumina A,Narels K,Pole I,Ranka R,Pliss L

更新日期：2015-01-01 00:00:00

abstract：:In agreement with previous studies we show an age-related increase in serum levels of hyaluronic acid in healthy individuals. Levels in Down's syndrome persons were slightly higher, especially in those with hypothyroidism. This provides further evidence that the normal ageing process is accelerated in Down's syndrome....

journal_title：Mechanisms of ageing and development

authors： Hutchin T,Martin L,Prasher V,Sinclair AJ

更新日期：1998-12-01 00:00:00

abstract：:The progression of many neurodegenerative diseases is assumed to be caused by misfolding of specific characteristic diseases related proteins, resulting in aggregation and fibril formation of these proteins. Protein misfolding associated age related diseases, although different in disease manifestations, share strikin...

journal_title：Mechanisms of ageing and development

authors： Eftekharzadeh B,Hyman BT,Wegmann S

更新日期：2016-06-01 00:00:00

abstract：:Formalinized Mycoplasma pulmonis was used to immunize 3 different age groups of Fischer 344 rats. A specific antibody to this antigen was detected in both saliva and lung lavage fluids and differences were noted in the elicitation of secretory antibody between the different ages of the animals. Few statistical differe...

journal_title：Mechanisms of ageing and development

authors： Steffen MJ,Ebersole JL

更新日期：1992-11-01 00:00:00

abstract：:Published data on age-related human biological functions are surveyed. For the many showing a linear decrease, regressions were calculated, or existing functions extrapolated, to yield an intercept on the abscissa. The values of chi(0), the age at which a function ceases, provide a tentative common means of comparison...

journal_title：Mechanisms of ageing and development

authors： Weale RA

更新日期：1993-06-01 00:00:00

abstract：:Ageing of WI-38 fibroblasts in culture was used as a model in order to investigate the evolution and the alteration of the key antioxidant enzyme glutathione peroxidase. The activity of glutathione peroxidase is influenced by the presence of selenium in the culture medium and we have also shown that the specific activ...

journal_title：Mechanisms of ageing and development

authors： Pigeolet E,Remacle J

更新日期：1991-04-01 00:00:00

abstract：:The risk for developing colorectal cancer increases exponentially with age. We demonstrate that spontaneous loss of folate in the colon results in DNA damage accumulation and aberrant DNA damage responses that may contribute to the increased genomic instability and cancer risk in colon. We find greater than 2-fold cha...

journal_title：Mechanisms of ageing and development

authors： Simon KW,Ma H,Dombkowski AA,Cabelof DC

更新日期：2012-02-01 00:00:00

abstract：:Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids leve...

journal_title：Mechanisms of ageing and development

authors： Muresan XM,Sticozzi C,Belmonte G,Savelli V,Evelson P,Valacchi G

更新日期：2018-06-01 00:00:00

abstract：:The general objective of this study was to examine the relationship between oxygen free radicals and the aging process. The rate of superoxide anion radical (O2.-) generation was measured in liver sub-mitochondrial particles from mouse, rat, rabbit, pig and cow, and in flight muscle sub-mitochondrial particles from th...

journal_title：Mechanisms of ageing and development

authors： Sohal RS,Svensson I,Sohal BH,Brunk UT

更新日期：1989-08-01 00:00:00

abstract：:Age-specific incidence rates for cancers of the female breast, ovary, corpus uteri, testis, prostate and male and female cancers of the stomach, colon, rectum, lung, and male and female Hodgkin's disease in 51 worldwide populations in the 1990 era were obtained from a published source. For each cancer in each populati...

journal_title：Mechanisms of ageing and development

authors： Dix D

更新日期：2003-03-01 00:00:00

abstract：:Oxidative energy metabolism in mouse liver mitochondria was examined during weaning using different substrates. During the post-natal development, from suckling to weanling stage, the respiration rates showed a temporary decrease. These altered levels recovered in the adults. Respiration rates with the three substrate...

journal_title：Mechanisms of ageing and development

authors： Subramanian M,Katyare SS

更新日期：1990-05-30 00:00:00