IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus.

abstract：OBJECTIVES:Vascular endothelial growth factor (VEGF) is thought to play an important role in systemic sclerosis (SSc) pathogenesis. It was found to be upregulated in the serum and in the affected skin of scleroderma patients. However, its involvement in scleroderma lung disease is not clear. This study aimed to evaluat...

journal_title：Annals of the rheumatic diseases

authors： De Santis M,Bosello SL,Capoluongo E,Inzitari R,Peluso G,Lulli P,Zizzo G,Bocci M,Tolusso B,Zuppi C,Castagnola M,Ferraccioli G

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:To assess the diagnostic value of ultrasonography (US) in the evaluation of arthritic shoulder joints. METHODS:Twenty shoulders of 20 inpatients with arthritis were evaluated by US one day before the shoulder operation. Changes in the subacromial-subdeltoid bursa, biceps tendon and tendon sheath, rotatof cuf...

journal_title：Annals of the rheumatic diseases

authors： Alasaarela E,Leppilahti J,Hakala M

更新日期：1998-06-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is highly prevalent in Malaysia, which has a mixed population of Malays, Chinese, and Indians. A quantitative enzyme linked immunosorbent assay (ELISA) was used to determine anticardiolipin antibody (aCL) levels (total immunoglobulin, IgG, and IgM) in 200 patients with SLE (164 Chine...

journal_title：Annals of the rheumatic diseases

authors： Jones HW,Ireland R,Senaldi G,Wang F,Khamashta M,Bellingham AJ,Veerapan K,Hughes GR,Vergani D

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Psoriatic arthritis (PsA) is a chronic inflammatory disease, characterised by synovitis and destruction of articular cartilage/bone. Janus-kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway is implicated in the pathogenesis of PsA. OBJECTIVES:To examine the effect of t...

journal_title：Annals of the rheumatic diseases

authors： Gao W,McGarry T,Orr C,McCormick J,Veale DJ,Fearon U

更新日期：2016-01-01 00:00:00

abstract：:The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This artic...

journal_title：Annals of the rheumatic diseases

authors： Flossmann O,Bacon P,de Groot K,Jayne D,Rasmussen N,Seo P,Westman K,Luqmani R

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:To compare patterns of arteriographic lesions of the aorta and primary branches in patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA). METHODS:Patients were selected from two North American cohorts of TAK and GCA. The frequency of arteriographic lesions was calculated for 15 large arter...

journal_title：Annals of the rheumatic diseases

authors： Grayson PC,Maksimowicz-McKinnon K,Clark TM,Tomasson G,Cuthbertson D,Carette S,Khalidi NA,Langford CA,Monach PA,Seo P,Warrington KJ,Ytterberg SR,Hoffman GS,Merkel PA,Vasculitis Clinical Research Consortium.

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with chronic knee pain. METHODS:A randomised, double-blind, four-arm, parallel-group, active controlled trial investigating short-term (day 10) and long-term (...

journal_title：Annals of the rheumatic diseases

authors： Doherty M,Hawkey C,Goulder M,Gibb I,Hill N,Aspley S,Reader S

更新日期：2011-09-01 00:00:00

abstract：:Thirteen patients were studied after jejunoileal bypass (JIB) surgery. Seven developed arthritis and six did not. Circulating immune complexes containing IgG and IgA were detected in the sera of patients with and without arthritis. IgA complexes were shown to contain secretory component, a protein predominantly associ...

journal_title：Annals of the rheumatic diseases

authors： Clegg DO,Zone JJ,Samuelson CO Jr,Ward JR

更新日期：1985-04-01 00:00:00

abstract：:Patients who develop reactive arthritis after yersinia enteritis are characterised by high and persisting IgA-anti-yersinia antibodies. We have further analysed the humoral immune response to yersinia in this condition. Total concentrations of IgM, IgG, IgA, and secretory IgA in the serum and specific anti-yersinia an...

journal_title：Annals of the rheumatic diseases

authors： Granfors K,Toivanen A

更新日期：1986-07-01 00:00:00

abstract：OBJECTIVE:Rheumatoid arthritis (RA) accompanies infiltration and activation of monocytes in inflamed joints. We investigated dominant alterations of RA monocytes in bone marrow (BM), blood and inflamed joints. METHODS:CD14+ cells from BM and peripheral blood (PB) of patients with RA and osteoarthritis (OA) were profil...

journal_title：Annals of the rheumatic diseases

authors： Smiljanovic B,Radzikowska A,Kuca-Warnawin E,Kurowska W,Grün JR,Stuhlmüller B,Bonin M,Schulte-Wrede U,Sörensen T,Kyogoku C,Bruns A,Hermann S,Ohrndorf S,Aupperle K,Backhaus M,Burmester GR,Radbruch A,Grützkau A,Maslinski

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of...

journal_title：Annals of the rheumatic diseases

authors： Kloppenburg M,Stamm T,Watt I,Kainberger F,Cawston TE,Birrell FN,Petersson IF,Saxne T,Kvien TK,Slatkowsky-Christensen B,Dougados M,Gossec L,Breedveld FC,Smolen JS

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:To investigate the elastic properties of the ascending aorta in untreated patients with giant cell arteritis compared with age and sex matched normal controls. METHODS:Distensibility of the ascending aorta and aortic strain were measured in 22 patients with a recent diagnosis of giant cell arteritis (documen...

journal_title：Annals of the rheumatic diseases

authors： Margos PN,Moyssakis IE,Tzioufas AG,Zintzaras E,Moutsopoulos HM

更新日期：2005-02-01 00:00:00

abstract：:A new method is described for separating free 35SO4-- from 35SO4 labelled proteoglycans synthesised by rabbit articular chondrocytes cultured in the presence of excess 35SO4--. The procedure uses the low solubility product of barium sulphate to remove, by precipitation, free 35SO4-- from culture medium. Optimum recove...

journal_title：Annals of the rheumatic diseases

authors： Collier S,Ghosh P

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVES:To perform a systematic literature review of effective strategies for the treatment of rheumatoid arthritis (RA). METHODS:As part of a European League Against Rheumatism (EULAR) Task Force investigation, a literature search was carried out from January 1962 until February 2009 in PubMed/Ovid Embase/Cochrane...

journal_title：Annals of the rheumatic diseases

authors： Knevel R,Schoels M,Huizinga TW,Aletaha D,Burmester GR,Combe B,Landewé RB,Smolen JS,Sokka T,van der Heijde DM

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To study the long term effectiveness of intravenous immunoglobulin and plasmapheresis associated with prednisone and cyclophosphamide in Churg-Strauss syndrome. SUBJECTS:and methods: We studied 18 subjects with new onset Churg-Strauss syndrome. All received the "standard" treatment based on prednisone (1 mg/...

journal_title：Annals of the rheumatic diseases

authors： Danieli MG,Cappelli M,Malcangi G,Logullo F,Salvi A,Danieli G

更新日期：2004-12-01 00:00:00

abstract：:This article gives a short overview of the development and characteristics of the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS), followed by an introduction to the use of the EULAR-OMERACT rheumatoid arthritis MRI reference image atlas. With this atlas, MRIs of wrist and metacarpophalangeal joints of patien...

journal_title：Annals of the rheumatic diseases

authors： Østergaard M,Edmonds J,McQueen F,Peterfy C,Lassere M,Ejbjerg B,Bird P,Emery P,Genant H,Conaghan P

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:High resolution ultrasound (HRUS) was used to investigate the effects of tumour necrosis factor alpha (TNFalpha) blockade on pannus formation and vascularisation of small finger joints in patients with active rheumatoid arthritis (RA). METHODS:Five patients with active RA were treated with etanercept, a solu...

journal_title：Annals of the rheumatic diseases

authors： Hau M,Kneitz C,Tony HP,Keberle M,Jahns R,Jenett M

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Regulatory T cells (Tregs) with the plasticity of producing proinflammatory cytokine IL-17 have been demonstrated under normal and pathogenic conditions. However, it remains unclear whether IL-17-producing Tregs lose their suppressive functions because of their plasticity toward Th17 in autoimmunity. The aim ...

journal_title：Annals of the rheumatic diseases

authors： Wang T,Sun X,Zhao J,Zhang J,Zhu H,Li C,Gao N,Jia Y,Xu D,Huang FP,Li N,Lu L,Li ZG

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Immunogenicity of aTNFs is one of the mechanisms behind treatment failure. OBJECTIVE:To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab, adalimumab and etanercept, and the effect of immunosuppression on ADA detection, in patients with Rheumatoid Arthritis, Spondyloarthritis, P...

journal_title：Annals of the rheumatic diseases

authors： Garcês S,Demengeot J,Benito-Garcia E

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:To assess the effect of an intra-articular presentation of stress (heat shock) proteins (hsp) on joint inflammation. METHODS:Wistar rats were sensitised with a suspension of heat killed Mycobacterium tuberculosis in oil in the scruff of the neck and challenged intra-articularly with stress protein or M tube...

journal_title：Annals of the rheumatic diseases

authors： Winrow VR,Ragno S,Morris CJ,Colston MJ,Mascagni P,Leoni F,Gromo G,Coates AR,Blake DR

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVES:To describe the influence of the reading order (chronological v paired) on radiographic scoring results in ankylosing spondylitis. To investigate whether this method is sufficiently sensitive to change because paired reading is requested for establishing drug efficacy in clinical trials. METHODS:Films obtai...

journal_title：Annals of the rheumatic diseases

authors： Wanders A,Landewé R,Spoorenberg A,de Vlam K,Mielants H,Dougados M,van der Linden S,van der Heijde D

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:An investigator-initiated, double-blinded, placebo-controlled, treat-to-target protocol (Clinical Trials:NCT00660647) studied whether adalimumab added to methotrexate and intra-articular triamcinolone as first-line treatment in early rheumatoid arthritis (ERA) increased the frequency of low disease activity ...

journal_title：Annals of the rheumatic diseases

authors： Hørslev-Petersen K,Hetland ML,Junker P,Pødenphant J,Ellingsen T,Ahlquist P,Lindegaard H,Linauskas A,Schlemmer A,Dam MY,Hansen I,Horn HC,Ammitzbøll CG,Jørgensen A,Krintel SB,Raun J,Johansen JS,Østergaard M,Stengaard-Pe

更新日期：2014-04-01 00:00:00

abstract：:The circulating levels of sialic acid (N-acetylneuraminic acid) and glycosaminoglycans (GAGs) were measured in 69 patients with spinal disorders of orthopaedic interest (ankylosing spondylitis 17, osteofluorosis 6, idiopathic backache 10, osteoarthrosis 16, osteoporosis 20). The serum GAG levels showed no statisticall...

journal_title：Annals of the rheumatic diseases

authors： Susheela AK,Das TK,Khurana JS,Jayaswal A,Dave PK

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of tumour necrosis factor alpha (TNFalpha) blockers on the presence of liver fibrosis in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA) treated with methotrexate (MTX). METHODS:Participants were consecutive patients with RA and PsA who had undergone MTX treatment...

journal_title：Annals of the rheumatic diseases

authors： Seitz M,Reichenbach S,Möller B,Zwahlen M,Villiger PM,Dufour JF

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Whether preradiographic lesions in knees at risk for osteoarthritis are incidental versus disease is unclear. We hypothesised, in persons without but at higher risk for knee osteoarthritis, that: 12-48 month MRI lesion status worsening is associated with 12-48 month incident radiographic osteoarthritis (obje...

journal_title：Annals of the rheumatic diseases

authors： Sharma L,Nevitt M,Hochberg M,Guermazi A,Roemer FW,Crema M,Eaton C,Jackson R,Kwoh K,Cauley J,Almagor O,Chmiel JS

更新日期：2016-09-01 00:00:00

abstract：:In view of the association of congenital heart block with maternal antibody to cellular antigen Ro (SSA), and one report linking anti-Ro with myocarditis in a patient with myositis an association between anti-Ro antibodies and cardiac disease was sought in adults with systemic lupus erythematosus (SLE). Among 67 patie...

journal_title：Annals of the rheumatic diseases

authors： Logar D,Kveder T,Rozman B,Dobovisek J

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:Gout, caused by hyperuricaemia, is a multifactorial disease. Although genome-wide association studies (GWASs) of gout have been reported, they included self-reported gout cases in which clinical information was insufficient. Therefore, the relationship between genetic variation and clinical subtypes of gout r...

journal_title：Annals of the rheumatic diseases

authors： Matsuo H,Yamamoto K,Nakaoka H,Nakayama A,Sakiyama M,Chiba T,Takahashi A,Nakamura T,Nakashima H,Takada Y,Danjoh I,Shimizu S,Abe J,Kawamura Y,Terashige S,Ogata H,Tatsukawa S,Yin G,Okada R,Morita E,Naito M,Tokumasu

更新日期：2016-04-01 00:00:00

abstract：:The prevalence of anticardiolipin antibodies was evaluated in 70 children with juvenile chronic arthritis (JCA), in 25 adult patients with rheumatoid arthritis, in 42 healthy children and in 40 adult controls. Thirty seven (53%) patients with JCA were positive for IgG or IgM anticardiolipin antibodies, or both, and 30...

journal_title：Annals of the rheumatic diseases

authors： Caporali R,Ravelli A,De Gennaro F,Neirotti G,Montecucco C,Martini A

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVES:Improved DNA sequencer-aided fluorophore-assisted carbohydrate electrophoresis (DSA-FACE) technology was used to monitor the changes in the galactosylation status of serum immunoglobulins during the immune response and therapy of autoimmune arthritis. METHODS:Collagen-induced arthritis (CIA) was induced in ...

journal_title：Annals of the rheumatic diseases

authors： Van Beneden K,Coppieters K,Laroy W,De Keyser F,Hoffman IE,Van den Bosch F,Vander Cruyssen B,Drennan M,Jacques P,Rottiers P,Verbruggen G,Contreras R,Callewaert N,Elewaut D

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy and safety of innovator infliximab (INX) and CT-P13, an INX biosimilar, in active rheumatoid arthritis patients with inadequate response to methotrexate (MTX) treatment. METHODS:Phase III randomised, double-blind, multicentre, multinational, parallel-group study. Patients with active...

journal_title：Annals of the rheumatic diseases

authors： Yoo DH,Hrycaj P,Miranda P,Ramiterre E,Piotrowski M,Shevchuk S,Kovalenko V,Prodanovic N,Abello-Banfi M,Gutierrez-Ureña S,Morales-Olazabal L,Tee M,Jimenez R,Zamani O,Lee SJ,Kim H,Park W,Müller-Ladner U

更新日期：2013-10-01 00:00:00