Tofacitinib regulates synovial inflammation in psoriatic arthritis, inhibiting STAT activation and induction of negative feedback inhibitors.

abstract：OBJECTIVES:A prospective randomised trial to compare two different durations of maintenance immunosuppressive therapy for the prevention of relapse in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV). METHODS:Patients with AAV were recruited 18-24 months after diagnosis if they were in stable ...

journal_title：Annals of the rheumatic diseases

authors： Karras A,Pagnoux C,Haubitz M,Groot K,Puechal X,Tervaert JWC,Segelmark M,Guillevin L,Jayne D,European Vasculitis Society.

更新日期：2017-10-01 00:00:00

abstract：:Symptomatic osteonecrosis occurred in 8 out of 68 patients with systemic lupus erythematosus. Multiple joints were involved in 3 patients, and weight-bearing joints were most frequently affected. Osteonecrosis tended to occur early in the disease, and the patients had all received corticosteroids. Symptoms tended to o...

journal_title：Annals of the rheumatic diseases

authors： Griffiths ID,Maini RN,Scott JT

更新日期：1979-10-01 00:00:00

abstract：OBJECTIVE:To study the value of antibodies to citrullinated proteins/peptides for predicting joint outcomes in patients with recent onset rheumatoid arthritis (RA). METHODS:191 patients with RA onset within the past year were followed up prospectively for five years. Serum samples obtained from 145 patients at baselin...

journal_title：Annals of the rheumatic diseases

authors： Meyer O,Labarre C,Dougados M,Goupille P,Cantagrel A,Dubois A,Nicaise-Roland P,Sibilia J,Combe B

更新日期：2003-02-01 00:00:00

abstract：:A family is described in which the mother and 2 of the 5 children had Felty's syndrome, a pattern of inheritance suggesting a dominant defect and one which has not previously been reported. The family is also of interest in that the other sib had rheumatoid arthritis. ...

journal_title：Annals of the rheumatic diseases

authors： Blendis LM,Jones KL,Hamilton EB,Williams R

更新日期：1976-06-01 00:00:00

abstract：:It has been proposed that the process of hypoxic-reperfusion injury contributes to the persistence of synovitis in the inflamed human joint. The generation of pathological, exercise induced, intra-articular pressure leading to occlusion of the synovial microcirculation is central to this mechanism. However, acute trau...

journal_title：Annals of the rheumatic diseases

authors： Merry P,Williams R,Cox N,King JB,Blake DR

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis of the skin and the internal organs. Except for anticentromere, antitopoisomerase I and antipolymerase III antibodies, there are no reliable circulating markers predicting susceptibility and internal organ complications. This study h...

journal_title：Annals of the rheumatic diseases

authors： van Bon L,Cossu M,Loof A,Gohar F,Wittkowski H,Vonk M,Roth J,van den Berg W,van Heerde W,Broen JC,Radstake TR

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVES:Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. In most studies, neutrophils were analysed for mPR3 expression without prim...

journal_title：Annals of the rheumatic diseases

authors： van Rossum AP,Huitema MG,Stegeman CA,Bijl M,de Leeuw K,Van Leeuwen MA,Limburg PC,Kallenberg CG

更新日期：2007-10-01 00:00:00

abstract：:Gout and classical rheumatoid arthritis rarely coexist. We report a patient with strong evidence for both these diseases. Possible reasons for the negative correlation between these diseases are summarised. One hypothesis suggests inhibition of surface activity of monosodium urate crystals (MSU) by binding of rheumato...

journal_title：Annals of the rheumatic diseases

authors： Gordon TP,Ahern MJ,Reid C,Roberts-Thomson PJ

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:To localise and characterise follicular dendritic cells (FDC) present in autoimmune lesions of primary Sjögren syndrome. METHODS:Cryostat sections of labial salivary glands from 15 patients with primary Sjögren syndrome were examined by an indirect immunoperoxidase technique and monoclonal antibodies to a pa...

journal_title：Annals of the rheumatic diseases

authors： Aziz KE,McCluskey PJ,Wakefield D

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:To study the correlation between ankle and knee cartilage morphology to test the hypothesis that knee joint cartilage loss in gonarthritis can be estimated retrospectively using quantitative MRI analysis of the knee and ankle and established regression equations; and to test the hypothesis that sex difference...

journal_title：Annals of the rheumatic diseases

authors： Eckstein F,Siedek V,Glaser C,Al-Ali D,Englmeier KH,Reiser M,Graichen H

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Several inflammatory conditions are associated with an increased risk of lymphoma. The specific features of inflammation that mediate this risk are unknown. There are few studies on whether ankylosing spondylitis increases the risk of lymphoma. Besides inflammation-lymphoma aetiology, information on risk of ...

journal_title：Annals of the rheumatic diseases

authors： Askling J,Klareskog L,Blomqvist P,Fored M,Feltelius N

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:To develop evidence-based EULAR recommendations for cardiovascular (CV) risk management in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA). METHODS:A multidisciplinary expert committee was convened as a task force of the EULAR Standing Committee for Clinica...

journal_title：Annals of the rheumatic diseases

authors： Peters MJ,Symmons DP,McCarey D,Dijkmans BA,Nicola P,Kvien TK,McInnes IB,Haentzschel H,Gonzalez-Gay MA,Provan S,Semb A,Sidiropoulos P,Kitas G,Smulders YM,Soubrier M,Szekanecz Z,Sattar N,Nurmohamed MT

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVES:To compare patterns of arteriographic lesions of the aorta and primary branches in patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA). METHODS:Patients were selected from two North American cohorts of TAK and GCA. The frequency of arteriographic lesions was calculated for 15 large arter...

journal_title：Annals of the rheumatic diseases

authors： Grayson PC,Maksimowicz-McKinnon K,Clark TM,Tomasson G,Cuthbertson D,Carette S,Khalidi NA,Langford CA,Monach PA,Seo P,Warrington KJ,Ytterberg SR,Hoffman GS,Merkel PA,Vasculitis Clinical Research Consortium.

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:Annual echocardiography screening is widely used in scleroderma, but the utility of longitudinal assessment is unknown. We evaluated whether change in right ventricular systolic pressure (RVSP) was a risk factor for mortality and development of pulmonary arterial hypertension (PAH) in a cohort of scleroderma...

journal_title：Annals of the rheumatic diseases

authors： Shah AA,Chung SE,Wigley FM,Wise RA,Hummers LK

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:To measure hyaluronic acid (HA) levels, which are raised in active rheumatoid arthritis (RA), in patients with early RA, and to assess the correlation with clinical and laboratory indices of disease activity and with subsequent radiographic erosive status. PATIENTS AND METHODS:Patients fulfilling ACR criter...

journal_title：Annals of the rheumatic diseases

authors： Majeed M,McQueen F,Yeoman S,McLean L

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:To identify potential risk factors for the onset of inflammatory arthritis (IA) in a large cohort of patients with psoriatic arthritis (PsA) of recent onset. METHODS:We recruited cases with psoriasis and an onset of IA within the past 5 years. Controls were patients who had psoriasis but no arthritis. We ass...

journal_title：Annals of the rheumatic diseases

authors： Pattison E,Harrison BJ,Griffiths CE,Silman AJ,Bruce IN

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To compare the clinical, radiological, and biological profile of patients presenting late onset spondylarthropathy (LOSPA) with patients with early onset spondylarthropathy (EOSPA). METHODS:During the period April 1987 to April 1995 a retrospective chart review of inpatients and outpatients identified eight ...

journal_title：Annals of the rheumatic diseases

authors： Caplanne D,Tubach F,Le Parc JM

更新日期：1997-03-01 00:00:00

abstract：:A 35 year old woman presented with headache and fever. Computed brain tomography showed diffuse low attenuation in the cerebral white matter. Several months later, serological tests for systemic lupus erythematosus (SLE) became positive. In spite of immunosuppressive therapy she relapsed after six months of treatment,...

journal_title：Annals of the rheumatic diseases

authors： Boulter M,Brink A,Mathias C,Peart S,Stevens J,Stewart G,Unwin R

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE:To investigate the involvement of interleukin-1 (IL-1) in the induction or maintenance of the insulin-like growth factor 1 (IGF-1) non-responsive state of chondrocytes during experimental arthritis in mouse knee joints. METHODS:To characterise IGF-1 nonresponsiveness during arthritis, we measured chondrocyte...

journal_title：Annals of the rheumatic diseases

authors： Verschure PJ,Joosten LA,Van de Loo FA,Van den Berg WB

更新日期：1995-12-01 00:00:00

abstract：:Serum IgG antibodies to native and denatured human type II collagen (Col II) were measured using an enzyme linked immunosorbent assay (ELISA). One hundred and thirty one patients with various forms of arthritis such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PSA). Reiter's Syndrome...

journal_title：Annals of the rheumatic diseases

authors： Choi EK,Gatenby PA,McGill NW,Bateman JF,Cole WG,York JR

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:To describe the associations between overweight measures in childhood and knee pain, stiffness and dysfunction among adults 25 years later. METHODS:Subjects broadly representative of the Australian population (n=449, aged 31-41 years, female 48%) were selected from the Australian Schools Health and Fitness S...

journal_title：Annals of the rheumatic diseases

authors： Antony B,Jones G,Venn A,Cicuttini F,March L,Blizzard L,Dwyer T,Cross M,Ding C

更新日期：2015-04-01 00:00:00

abstract：:Twenty-five patients (22 males and 3 females) are described who had 'unclassifiable' seronegative peripheral arthritis affecting mainly the large joints of the lower limbs with other typical features of spondyloarthropathies such as heel pain, low back pain, and mucosal ulcers. But their disorders could not be diagnos...

journal_title：Annals of the rheumatic diseases

authors： Prakash S,Mehra NK,Bhargava S,Malaviya AN

更新日期：1983-12-01 00:00:00

abstract：:The incidence of exacerbations in the disease course was investigated in 110 patients with systemic lupus erythematosus (SLE) who were studied prospectively at our institute for lupus research. At the time of disease onset and diagnosis the male patients were much older than the female patients (about 10 years); exace...

journal_title：Annals of the rheumatic diseases

authors： Swaak AJ,Nossent JC,Bronsveld W,van Rooyen A,Nieuwenhuys EJ,Theuns L,Smeenk RJ

更新日期：1989-06-01 00:00:00

abstract：:Superantigens are bacterial, viral, or retroviral proteins which can activate specifically a large proportion of T cells. In contrast with classical peptide antigen recognition, superantigens do not require processing to small peptides but act as complete or partially processed proteins. They can bind to major histoco...

journal_title：Annals of the rheumatic diseases

authors： Acha-Orbea H

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:The prevalence and clinical outcomes of COVID-19 in patients with autoimmune diseases who are frequently treated with disease modifying therapies remains poorly understood. This meta-analysis aims to assess the prevalence and clinical outcomes of COVID-19 in autoimmune diseases. METHODS:Electronic databases...

journal_title：Annals of the rheumatic diseases

authors： Akiyama S,Hamdeh S,Micic D,Sakuraba A

更新日期：2020-10-13 00:00:00

abstract：OBJECTIVES:To perform a systematic literature review of effective strategies for the treatment of rheumatoid arthritis (RA). METHODS:As part of a European League Against Rheumatism (EULAR) Task Force investigation, a literature search was carried out from January 1962 until February 2009 in PubMed/Ovid Embase/Cochrane...

journal_title：Annals of the rheumatic diseases

authors： Knevel R,Schoels M,Huizinga TW,Aletaha D,Burmester GR,Combe B,Landewé RB,Smolen JS,Sokka T,van der Heijde DM

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVES:Lipid profiles are altered by active disease in patients with rheumatoid arthritis (RA) and may be further modified by treatment with Janus kinase inhibitors and other disease-modifying antirheumatic drugs. METHODS:Lipid data were analysed from phase II and III studies of 4 mg (n=997) and 2 mg (n=479) oral ...

journal_title：Annals of the rheumatic diseases

authors： Taylor PC,Kremer JM,Emery P,Zuckerman SH,Ruotolo G,Zhong J,Chen L,Witt S,Saifan C,Kurzawa M,Otvos JD,Connelly MA,Macias WL,Schlichting DE,Rooney TP,de Bono S,McInnes IB

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVES:The balance between interferon gamma (IFN gamma) and interleukin 4 (IL4) producing T cells (T1 and T2 cells) seems to be of importance in many (auto)immune disorders. In general, T1 cell activity is important in cellular immunity whereas T2 cell activity plays a part in humoral responses. T1 cell activity pr...

journal_title：Annals of the rheumatic diseases

authors： Verhoef CM,van Roon JA,Vianen ME,Bruijnzeel-Koomen CA,Lafeber FP,Bijlsma JW

更新日期：1998-05-01 00:00:00

abstract：:Biological therapies directed at proinflammatory cytokines have irrevocably changed the landscape of treatment of rheumatoid arthritis (RA) and other autoimmune diseases. With the advances in our knowledge in cytokine signalling, the question emerges whether targeting intracellular signalling might also be a safe and ...

journal_title：Annals of the rheumatic diseases

authors： O'Shea JJ,Kontzias A,Yamaoka K,Tanaka Y,Laurence A

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:To analyse the similarities and discrepancies between the official rheumatology specialty training programmes across Europe. METHODS:A steering committee defined the main aspects of training to be assessed. In 2013, the rheumatology official training programmes were reviewed for each of the European League ...

journal_title：Annals of the rheumatic diseases

authors： Sivera F,Ramiro S,Cikes N,Dougados M,Gossec L,Kvien TK,Lundberg IE,Mandl P,Moorthy A,Panchal S,da Silva JA,Bijlsma JW,Working Group on Training in Rheumatology across Europe.

更新日期：2015-06-01 00:00:00