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Characterisation of follicular dendritic cells in labial salivary glands of patients with primary Sjögren syndrome: comparison with tonsillar lymphoid follicles.

Abstract：

OBJECTIVE:To localise and characterise follicular dendritic cells (FDC) present in autoimmune lesions of primary Sjögren syndrome. METHODS:Cryostat sections of labial salivary glands from 15 patients with primary Sjögren syndrome were examined by an indirect immunoperoxidase technique and monoclonal antibodies to a panel of dendritic cell markers. Tonsils from two controls were also examined for the same markers. RESULTS:FDC were localised in the centre of 75% of lymphoid focal structures in labial salivary glands biopsies. FDC in labial salivary glands of patients with primary Sjögren syndrome expressed CD35, CD11c, and CD106 (VCAM-1) in a pattern similar to FDC in tonsils, but they did not express either CD14 or CD11b. This indicates that they may not be of myeloid origin, while FDC in tonsillar lymphoid follicles strongly expressed both CD14 and CD11b. FDC in labial salivary glands of patients also lacked VLA-2 alpha and VLA-3 alpha, which were expressed by FDC in tonsils. CONCLUSIONS:The characteristic phenotype and origin of these cells may be of importance in the immune responses involved in Sjögren syndrome and the retention of infiltrating lymphocytes in the glands.

journal_name

Ann Rheum Dis

journal_title

Annals of the rheumatic diseases

authors

Aziz KE,McCluskey PJ,Wakefield D

doi

10.1136/ard.56.2.140

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

140-3

issue

2

eissn

0003-4967

issn

1468-2060

journal_volume

56

pub_type

杂志文章

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