Hepatoprotective effect of tumour necrosis factor alpha blockade in psoriatic arthritis: a cross-sectional study.

abstract：OBJECTIVE:To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis. METHODS:Patients diagnosed as having axSpA in the Swiss Clinical Quality Management cohort ...

journal_title：Annals of the rheumatic diseases

authors： Micheroli R,Tellenbach C,Scherer A,Bürki K,Niederman K,Nissen MJ,Zufferey P,Exer P,Möller B,Kyburz D,Ciurea A

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Hospitalisation is a risk factor for flares in people with gout. However, the predictors of inpatient gout flare are not well understood. The aim of this study was to develop a prediction model for inpatient gout flare among people with comorbid gout. METHODS:We used data from a retrospective cohort of hosp...

journal_title：Annals of the rheumatic diseases

authors： Jatuworapruk K,Grainger R,Dalbeth N,Taylor WJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To assess sensory function in skin overlying the joints of patients with rheumatoid arthritis, in relation to the pain and tenderness which commonly arises in structures not directly involved in the inflammatory process. METHODS:An intradermal injection of capsaicin 0.05 microgram in 10 microliters was made ...

journal_title：Annals of the rheumatic diseases

authors： Jolliffe VA,Anand P,Kidd BL

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:To report 4-year imaging outcomes in the RAPID-axSpA (NCT01087762) study of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA), treated with certolizumab pegol (CZP). METHODS:This phase III, randomised trial was placebo-controlled and double-blind to week 24, d...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde D,Baraliakos X,Hermann KA,Landewé RBM,Machado PM,Maksymowych WP,Davies OR,de Peyrecave N,Hoepken B,Bauer L,Nurminen T,Braun J

更新日期：2018-05-01 00:00:00

abstract：:The circulating levels of sialic acid (N-acetylneuraminic acid) and glycosaminoglycans (GAGs) were measured in 69 patients with spinal disorders of orthopaedic interest (ankylosing spondylitis 17, osteofluorosis 6, idiopathic backache 10, osteoarthrosis 16, osteoporosis 20). The serum GAG levels showed no statisticall...

journal_title：Annals of the rheumatic diseases

authors： Susheela AK,Das TK,Khurana JS,Jayaswal A,Dave PK

更新日期：1988-10-01 00:00:00

abstract：:It has been proposed that the process of hypoxic-reperfusion injury contributes to the persistence of synovitis in the inflamed human joint. The generation of pathological, exercise induced, intra-articular pressure leading to occlusion of the synovial microcirculation is central to this mechanism. However, acute trau...

journal_title：Annals of the rheumatic diseases

authors： Merry P,Williams R,Cox N,King JB,Blake DR

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVES:While new treatments for rheumatoid arthritis (RA) have markedly improved disease control by targeting immune/inflammatory pathways, current treatments rarely induce remission, underscoring the need for therapies that target other aspects of the disease. Little is known about the regulation of disease severi...

journal_title：Annals of the rheumatic diseases

authors： Laragione T,Brenner M,Lahiri A,Gao E,Harris C,Gulko PS

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:To forecast, on the basis of the past and present position of rheumatologists in Europe, the competence needed in the future to secure and promote the specialty within the healthcare network. METHODS:Union Européenne des Médecins Spécialistes/European Board of Rheumatology (UEMS/EBR) questionnaire on (a) tr...

journal_title：Annals of the rheumatic diseases

authors： Amor B

更新日期：2000-08-01 00:00:00

abstract：:Whole gut lavage fluid is a useful source of material for the study of intestinal immunity and inflammation in humans. Systemic and mucosal antibodies to Klebsiella pneumoniae were measured by enzyme linked immunosorbent assay (ELISA) in serum samples and whole gut lavage fluid from 14 patients with ankylosing spondyl...

journal_title：Annals of the rheumatic diseases

authors： O'Mahony S,Anderson N,Nuki G,Ferguson A

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVES:To examine the expression of the natural killer (NK) antigen CD56, and T cell receptor delta chain antigen (TCR delta), expressed on the gamma delta T cell subset, in patients with scleroderma, and to correlate levels of expression with clinical characteristics. METHODS:Peripheral blood mononuclear cells (P...

journal_title：Annals of the rheumatic diseases

authors： Holcombe RF,Baethge BA,Wolf RE,Betzing KW,Stewart RM

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Earlier publications have suggested a possible role for the efflux transporter breast cancer resistance protein (BCRP) in acquired resistance to disease-modifying antirheumatic drugs (DMARDs) such as leflunomide and its metabolite A771726 (teriflunomide). However, there is no direct evidence that BCRP intera...

journal_title：Annals of the rheumatic diseases

authors： Kis E,Nagy T,Jani M,Molnár E,Jánossy J,Ujhellyi O,Német K,Herédi-Szabó K,Krajcsi P

更新日期：2009-07-01 00:00:00

abstract：:The prevalence of grade III or IV osteoarthritis was determined in 210 patients with chronic renal failure, of whom 94 were receiving chronic haemodialysis and 116 had functioning renal transplants. The prevalence of grade III or IV osteoarthritis was three times greater in patients under 65 than in a control populati...

journal_title：Annals of the rheumatic diseases

authors： Duncan IJ,Hurst NP,Sebben R,Milazzo SC,Disney A

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Entheseal fibrocartilage (EF) derangement is hypothesised to be pivotal to the pathogenesis of spondyloarthritis. Ultrasound is useful for visualisation of the enthesis but its role in EF visualisation is uncertain. This work aimed to demonstrate face and content validity of ultrasound for EF visualisation b...

journal_title：Annals of the rheumatic diseases

authors： Aydin SZ,Bas E,Basci O,Filippucci E,Wakefield RJ,Celikel C,Karahan M,Atagunduz P,Benjamin M,Direskeneli H,McGonagle D

更新日期：2010-12-01 00:00:00

abstract：:In a search for aspects of behaviour related to oral contraceptive use which might explain the favourable effect of oral contraception on the onset of rheumatoid arthritis (RA), cigarette smoking and alcohol consumption were studied as possible risk factors. Information on cigarette smoking and alcohol consumption was...

journal_title：Annals of the rheumatic diseases

authors： Hazes JM,Dijkmans BA,Vandenbroucke JP,de Vries RR,Cats A

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVES:The aim of this report is to demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) equivalence as well as similar efficacy, safety and immunogenicity between GP2013, a biosimilar rituximab, and innovator rituximab (RTX) in patients with rheumatoid arthritis (RA) with inadequate response or intolerance to...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Cohen SB,Tony HP,Scheinberg M,Kivitz A,Balanescu A,Gomez-Reino J,Cen L,Zhu P,Shisha T

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:To evaluate the influences of radiographic severity, quadriceps strength, knee pain, age, and gender on functional ability in patients with osteoarthritis of the knee. METHODS:Equal numbers of knee pain positive and negative respondents to a survey of registrants aged more than 55 years at a general practic...

journal_title：Annals of the rheumatic diseases

authors： McAlindon TE,Cooper C,Kirwan JR,Dieppe PA

更新日期：1993-04-01 00:00:00

abstract：:One hundred and two rural patients and 100 urban patients with rheumatoid arthritis and osteoarthrosis and 203 age and sex matched controls were visited in their homes to evaluate their problems, needs, and expectations. Although one would expect disability to affect the mobility of a person, it was found that rural p...

journal_title：Annals of the rheumatic diseases

authors： Cornelissen PG,Rasker JJ,Valkenburg HA

更新日期：1988-02-01 00:00:00

abstract：OBJECTIVE:In an unselected community sample of adults, to assess the role and importance of exposure to mechanical factors both at work and leisure in the aetiology of hip pain. METHOD:A population based prevalence case-control study. Cases and controls were identified from a population survey of 3847 subjects registe...

journal_title：Annals of the rheumatic diseases

authors： Pope DP,Hunt IM,Birrell FN,Silman AJ,Macfarlane GJ

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To investigate the possibility of drug-free remission in patients with psoriatic arthritis (PsA) in continuous remission. METHODS:Prospective observational study in disease-modifying antirheumatic drug (DMARD)-treated PsA patients in continuous disease remission (no musculoskeletal symptoms, no or minimal sk...

journal_title：Annals of the rheumatic diseases

authors： Araujo EG,Finzel S,Englbrecht M,Schreiber DA,Faustini F,Hueber A,Nas K,Rech J,Schett G

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:To examine objectively spatial patterns of osteophytes around the distal end of the femur and to identify distinct subgroups. METHODS:A sample of 107 human femora from a large skeletal population were selected for study. These femora included subjects with evidence of late stage osteoarthritis (that is, wit...

journal_title：Annals of the rheumatic diseases

authors： Shepstone L,Rogers J,Kirwan J,Silverman B

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:To test the hypothesis that PVAC, delipidated, deglycolipidated heat killed Mycobacterium vaccae, is an effective and safe treatment for psoriatic arthritis (PsA). This treatment has shown promising results in psoriasis. METHODS:36 patients with PsA in two centres were studied in this double blind, placebo ...

journal_title：Annals of the rheumatic diseases

authors： Dalbeth N,Yeoman S,Dockerty JL,Highton J,Robinson E,Tan PL,Herman D,McQueen FM

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:To evaluate changes in health-related quality of life (HRQoL) in patients with refractory juvenile idiopathic arthritis (JIA) who are being treated with etanercept. METHODS:53 patients with JIA from seven Dutch centres were included. HRQoL was measured by the Childhood Health Assessment Questionnaire (CHAQ),...

journal_title：Annals of the rheumatic diseases

authors： Prince FH,Geerdink LM,Borsboom GJ,Twilt M,van Rossum MA,Hoppenreijs EP,Cate RT,Koopman-Keemink Y,van Santen-Hoeufft M,Raat H,van Suijlekom-Smit LW

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:To identify potential risk factors for the onset of inflammatory arthritis (IA) in a large cohort of patients with psoriatic arthritis (PsA) of recent onset. METHODS:We recruited cases with psoriasis and an onset of IA within the past 5 years. Controls were patients who had psoriasis but no arthritis. We ass...

journal_title：Annals of the rheumatic diseases

authors： Pattison E,Harrison BJ,Griffiths CE,Silman AJ,Bruce IN

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:Although TNF-α inhibitors' striking effect on clinical symptoms have revolutionised the treatment of ankylosing spondylitis (AS), no certain influence on the development of spinal ankylosis and joint destruction has been documented. We wished to investigate whether improved treatment has affected the use of ...

journal_title：Annals of the rheumatic diseases

authors： Nystad TW,Furnes O,Havelin LI,Skredderstuen AK,Lie SA,Fevang BT

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:To investigate the first-ever incidence of acute myocardial infarction and stroke in a community based RA cohort compared with the general population. METHODS:The RA cohort consisted of all patients in a local RA register in Malmö, Sweden (n = 1022). The patients were recruited from private and hospital base...

journal_title：Annals of the rheumatic diseases

authors： Turesson C,Jarenros A,Jacobsson L

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVES:Rheumatoid arthritis (RA) is less common among men than women, and sex hormones have been suggested to play a part in the pathogenesis. Lower levels of testosterone have been demonstrated in men with RA, but it is not known if these changes precede the disease. METHODS:In a nested case-control study, using ...

journal_title：Annals of the rheumatic diseases

authors： Pikwer M,Giwercman A,Bergström U,Nilsson JÅ,Jacobsson LT,Turesson C

更新日期：2014-03-01 00:00:00

abstract：:The modulation of interleukin 1 (IL-1) effects on proteoglycan metabolism in intact murine patellar cartilage by transforming growth factor beta (TGF-beta) was investigated in vitro and in vivo. In vitro TGF-beta (400 pmol/l) had no effect on basal proteoglycan degradation. Proteoglycan degradation induced by IL-1, ho...

journal_title：Annals of the rheumatic diseases

authors： van Beuningen HM,van der Kraan PM,Arntz OJ,van den Berg WB

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:(1) To compare clinical outcome and symptomatology of rheumatoid cervical myelopathy between patients managed conservatively and surgically. (2) To determine if surgical outcome has improved since the series published from this unit in 1987. (3) To examine the role of magnetic resonance imaging (MRI) in the ...

journal_title：Annals of the rheumatic diseases

authors： Hamilton JD,Gordon MM,McInnes IB,Johnston RA,Madhok R,Capell HA

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Comprehensive multisystem clinical assessment using the Birmingham Vasculitis Activity score (BVAS) is widely used in therapeutic studies of systemic vasculitis. Extensive use suggested a need to revise the instrument. The previous version of BVAS has been revised, according to usage and reviewed by an exper...

journal_title：Annals of the rheumatic diseases

authors： Mukhtyar C,Lee R,Brown D,Carruthers D,Dasgupta B,Dubey S,Flossmann O,Hall C,Hollywood J,Jayne D,Jones R,Lanyon P,Muir A,Scott D,Young L,Luqmani RA

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:To determine if serum urate concentration is associated with development of hypertension in young adults. METHODS:Retrospective cohort analysis from 4752 participants with available serum urate and without hypertension at baseline from the Coronary Artery Risk Development in Young Adults (CARDIA) study; a mi...

journal_title：Annals of the rheumatic diseases

authors： Gaffo AL,Jacobs DR Jr,Sijtsma F,Lewis CE,Mikuls TR,Saag KG

更新日期：2013-08-01 00:00:00