Abstract:
:It has been proposed that the process of hypoxic-reperfusion injury contributes to the persistence of synovitis in the inflamed human joint. The generation of pathological, exercise induced, intra-articular pressure leading to occlusion of the synovial microcirculation is central to this mechanism. However, acute traumatic inflammatory joint effusions rarely result in chronic synovitis, suggesting that either the basic hypothesis is incorrect, or that joints with acute traumatic effusions show different intra-articular pressure dynamics. In this study the intra-articular pressure was measured at rest and during isometric exercise in five patients with acute traumatic joint effusions and in nine patients with chronic inflammatory joint effusions. The generation of intra-articular pressure in the patients with acute traumatic effusions was significantly lower at rest (mean 2.0 v 19.6 mm Hg) and during exercise (mean 13.7 v 222.5 mm Hg) than in the patients with chronic effusions. This was due to reflex muscular inhibition around the joint, which inhibited the pathological generation of intra-articular pressure. This difference in the ability to generate intra-articular pressure might mitigate against hypoxic-reperfusion injury in joints with acute traumatic effusions, thereby explaining the paradoxical clinical observation that patients with acute traumatic inflammatory joint effusions rarely develop chronic synovitis.
journal_name
Ann Rheum Disjournal_title
Annals of the rheumatic diseasesauthors
Merry P,Williams R,Cox N,King JB,Blake DRdoi
10.1136/ard.50.12.917subject
Has Abstractpub_date
1991-12-01 00:00:00pages
917-20issue
12eissn
0003-4967issn
1468-2060journal_volume
50pub_type
杂志文章abstract::The incidence of exacerbations in the disease course was investigated in 110 patients with systemic lupus erythematosus (SLE) who were studied prospectively at our institute for lupus research. At the time of disease onset and diagnosis the male patients were much older than the female patients (about 10 years); exace...
journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
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更新日期:1989-06-01 00:00:00
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journal_title:Annals of the rheumatic diseases
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
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journal_title:Annals of the rheumatic diseases
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doi:10.1136/ard.44.2.89
更新日期:1985-02-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究
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doi:10.1136/ard.36.6.569
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journal_title:Annals of the rheumatic diseases
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doi:10.1136/annrheumdis-2020-218946
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2006.068528
更新日期:2007-11-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/annrheumdis-2018-214644
更新日期:2019-05-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.51.1.61
更新日期:1992-01-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2009.108951
更新日期:2010-05-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2003.017210
更新日期:2004-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1136/ard.2005.039032
更新日期:2006-04-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.35.6.521
更新日期:1976-12-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/annrheumdis-2013-204235
更新日期:2015-01-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/annrheumdis-2015-208410
更新日期:2016-11-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2004.022970
更新日期:2005-03-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.51.2.272
更新日期:1992-02-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究
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更新日期:2021-02-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2007.080713
更新日期:2008-11-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2008.094706
更新日期:2009-10-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.2004.029538
更新日期:2005-06-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.44.10.716
更新日期:1985-10-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,随机对照试验
doi:10.1136/ard.2008.106484
更新日期:2009-12-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,评审
doi:10.1136/annrheumdis-2015-207841
更新日期:2015-12-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 临床试验,杂志文章
doi:10.1136/ard.62.6.534
更新日期:2003-06-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2013-10-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章
doi:10.1136/ard.34.4.298
更新日期:1975-08-01 00:00:00
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journal_title:Annals of the rheumatic diseases
pub_type: 杂志文章,多中心研究
doi:10.1136/ard.2007.085704
更新日期:2009-03-01 00:00:00