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Distribution of arterial lesions in Takayasu's arteritis and giant cell arteritis.

Abstract：

OBJECTIVES:To compare patterns of arteriographic lesions of the aorta and primary branches in patients with Takayasu's arteritis (TAK) and giant cell arteritis (GCA). METHODS:Patients were selected from two North American cohorts of TAK and GCA. The frequency of arteriographic lesions was calculated for 15 large arteries. Cluster analysis was used to derive patterns of arterial disease in TAK versus GCA and in patients categorised by age at disease onset. Using latent class analysis, computer derived classification models based upon patterns of arterial disease were compared with traditional classification. RESULTS:Arteriographic lesions were identified in 145 patients with TAK and 62 patients with GCA. Cluster analysis demonstrated that arterial involvement was contiguous in the aorta and usually symmetric in paired branch vessels for TAK and GCA. There was significantly more left carotid (p=0.03) and mesenteric (p=0.02) artery disease in TAK and more left and right axillary (p<0.01) artery disease in GCA. Subclavian disease clustered asymmetrically in TAK and in patients ≤55 years at disease onset and clustered symmetrically in GCA and patients >55 years at disease onset. Computer derived classification models distinguished TAK from GCA in two subgroups, defining 26% and 18% of the study sample; however, 56% of patients were classified into a subgroup that did not strongly differentiate between TAK and GCA. CONCLUSIONS:Strong similarities and subtle differences in the distribution of arterial disease were observed between TAK and GCA. These findings suggest that TAK and GCA may exist on a spectrum within the same disease.

journal_name

Ann Rheum Dis

journal_title

Annals of the rheumatic diseases

authors

Grayson PC,Maksimowicz-McKinnon K,Clark TM,Tomasson G,Cuthbertson D,Carette S,Khalidi NA,Langford CA,Monach PA,Seo P,Warrington KJ,Ytterberg SR,Hoffman GS,Merkel PA,Vasculitis Clinical Research Consortium.

doi

10.1136/annrheumdis-2011-200795

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

1329-34

issue

eissn

0003-4967

issn

1468-2060

pii

annrheumdis-2011-200795

journal_volume

pub_type

杂志文章,多中心研究

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Distribution of arterial lesions in Takayasu's arteritis and giant cell arteritis.