Reproductive history, hormonal factors and the incidence of hip and knee replacement for osteoarthritis in middle-aged women.


OBJECTIVES:To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS:A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission records was conducted. The adjusted relative risk (RR) of hip and knee replacement for osteoarthritis was examined in relation to parity, age at menarche, menopausal status, age at menopause and use of hormonal therapies. RESULTS:Over a mean of 6.1 person-years of follow-up, 12 124 women had a hip replacement and 9977 a knee replacement. The risk of joint replacement increased with increasing parity and the effect was greater for the knee than the hip: increase in RR of 2% (95% CI 1 to 4%) per birth for hip replacement and 8% (95% CI 6 to 10%) for knee replacement. An early age at menarche slightly increased the risk of hip and knee replacement (relative risk for menarche < or =11 years versus 12 years, 1.09 (95% CI 1.03 to 1.16) and 1.15 (95% CI 1.08 to 1.22), respectively). Menopausal status and age at menopause were not clearly associated with risk. Current use of postmenopausal hormone therapy was associated with a significant increase in the incidence of hip and knee replacement (RR 1.38 (95% CI 1.30 to 1.46) and RR 1.58 (95% CI 1.48 to 1.69), respectively) while previous use of oral contraceptives was not (RR 1.02 (95% CI 0.98 to 1.06) and RR 1.00 (95% CI 0.96 to 1.04) for hip and knee, respectively). CONCLUSIONS:Hormonal and reproductive factors affect the risk of hip and knee replacement, more so for the knee than the hip. The reasons for this are unclear.


Ann Rheum Dis


Liu B,Balkwill A,Cooper C,Roddam A,Brown A,Beral V,Million Women Study Collaborators.




Has Abstract


2009-07-01 00:00:00














  • In erosive hand osteoarthritis more inflammatory signs on ultrasound are found than in the rest of hand osteoarthritis.

    abstract:OBJECTIVE:To compare inflammation as assessed by ultrasound between patients with the subset erosive hand osteoarthritis (EOA) versus non-EOA. METHODS:Consecutive hand osteoarthritis (HOA) patients (fulfilling ACR criteria) were included. Eighteen interphalangeal joints were scored on radiographs using the Verbruggen-...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Kortekaas MC,Kwok WY,Reijnierse M,Huizinga TW,Kloppenburg M

    更新日期:2013-06-01 00:00:00

  • Shoulder-hand syndrome and symmetrical arthralgia in patients with tubo-ovarian carcinoma.

    abstract::Two cases of bilateral shoulder-hand syndrome and symmetrical arthralgia are described in patients with tubo-ovarian carcinoma. Swelling and contracture of the hands continued to develop despite oral corticosteroid therapy, and one patient underwent surgery in an attempt to prevent the development of further deformity...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Taggart AJ,Iveson JM,Wright V

    更新日期:1984-06-01 00:00:00

  • Efficacy of etanercept in the treatment of acute, severe sciatica: a pilot study.

    abstract:OBJECTIVES:To explore the efficacy of a tumour necrosis factor alpha (TNFalpha) inhibitor (etanercept, Enbrel) in patients with severe sciatica. METHODS:A pilot study of etanercept was conducted in patients admitted to hospital for acute severe sciatica. Ten consecutive patients received three subcutaneous injections ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章


    authors: Genevay S,Stingelin S,Gabay C

    更新日期:2004-09-01 00:00:00

  • Viscosity of plasma in patients with rheumatoid arthritis.

    abstract::The viscosity of plasma (PV) was investigated in 27 outpatients with classical or definite rheumatoid arthritis (RA) according to the American Rheumatism Association (ARA) criteria. The measurements showed a significantly raised PV in patients with RA (p less than 10(-5)) compared with a control group. There was a pos...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Harreby M,Danneskiold-Samsøe B,Kjer J,Lauritzen M

    更新日期:1987-08-01 00:00:00

  • Abdominal pain with free peritoneal fluid detected by ultrasonography as a presenting manifestation of acute rheumatic fever.

    abstract::The clinical and laboratory data for an 8 year old girl with abdominal pain as a presenting manifestation of acute rheumatic fever are reported. An abdominal investigation with ultrasonography carried out at the same time showed free peritoneal fluid. These findings support the proposal that the abdominal pain classic...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Picard E,Gedalia A,Benmeir P,Zucker N,Barki Y

    更新日期:1992-03-01 00:00:00

  • Bone loss in patients with active early rheumatoid arthritis: infliximab and methotrexate compared with methotrexate treatment alone. Explorative analysis from a 12-month randomised, double-blind, placebo-controlled study.

    abstract:OBJECTIVE:To examine the effect of infliximab plus methotrexate (MTX) compared with placebo plus MTX on bone loss in patients with early rheumatoid arthritis (RA) in a double-blind randomised study design. Further, to explore the associations between bone loss and markers of RA disease. METHODS:All 20 patients with RA...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验


    authors: Haugeberg G,Conaghan PG,Quinn M,Emery P

    更新日期:2009-12-01 00:00:00

  • Cardiovascular admissions and mortality in an inception cohort of patients with rheumatoid arthritis with onset in the 1980s and 1990s.

    abstract:BACKGROUND:There is increased cardiovascular disease mortality in rheumatoid arthritis. This may reflect an increased prevalence of cardiovascular disease or an increased case fatality in patients with rheumatoid arthritis. OBJECTIVES:To examine whether rheumatoid patients with disease onset in the 1980s-1990s have in...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究


    authors: Goodson N,Marks J,Lunt M,Symmons D

    更新日期:2005-11-01 00:00:00

  • Budd-Chiari syndrome as the major thrombotic complication of systemic lupus erythematosus with the lupus anticoagulant.

    abstract::A patient with systemic lupus erythematosus was first diagnosed after she had developed the Budd-Chiari syndrome. We believe that the Budd-Chiari syndrome was part of her tendency for thrombosis, induced by the presence of a lupus anticoagulant. The association between enhanced thrombosis and the lupus anticoagulant i...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Averbuch M,Levo Y

    更新日期:1986-05-01 00:00:00

  • Treatment of idiopathic retroperitoneal fibrosis using cyclosporin.

    abstract::The main goal of traditional treatment of idiopathic retroperitoneal fibrosis is limitation of morbidity, and surgery of already formed fibrous masses has been the main therapeutic approach. More recently, the knowledge that the disorder may be the result of an allergic reaction to atherosclerotic lipids has prompted ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Marzano A,Trapani A,Leone N,Actis GC,Rizzetto M

    更新日期:2001-04-01 00:00:00

  • Pyrophosphate arthropathy: a clinical and radiological study of 105 cases.

    abstract::105 consecutive patients who presented to a rheumatologist because of joint disease and who also had evidence of deposition of calcium pyrophosphate dihydrate (CPD) were studied clinically and radiologically. There were 76 women (mean age 73) and 29 men (mean age 62). Of only 18 patients below the age of 60 at present...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Dieppe PA,Alexander GJ,Jones HE,Doherty M,Scott DG,Manhire A,Watt I

    更新日期:1982-08-01 00:00:00

  • Osteoarthritis and articular chondrocalcinosis in the elderly.

    abstract::One hundred consecutive admissions to an acute geriatric unit were examined for clinical and radiographic evidence of osteoarthritis (OA) and articular chondrocalcinosis (ACC). Thirty-four patients had ACC. This was age related, the prevalence rising from 15% in patients aged 65-74 years to 44% in patients over 84 yea...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Wilkins E,Dieppe P,Maddison P,Evison G

    更新日期:1983-06-01 00:00:00

  • Clinical and radiological features of osteonecrosis in systemic lupus erythematosus.

    abstract::Symptomatic osteonecrosis occurred in 8 out of 68 patients with systemic lupus erythematosus. Multiple joints were involved in 3 patients, and weight-bearing joints were most frequently affected. Osteonecrosis tended to occur early in the disease, and the patients had all received corticosteroids. Symptoms tended to o...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Griffiths ID,Maini RN,Scott JT

    更新日期:1979-10-01 00:00:00

  • FoxO3a involved in neutrophil and T cell survival is overexpressed in rheumatoid blood and synovial tissue.

    abstract:OBJECTIVE:FoxO3a is a transcriptional factor implicated in cell cycle regulation and apoptosis. Since rheumatoid arthritis (RA) is associated with apoptosis defects, the expression level, regulation and phosphorylation status of FoxO3a was investigated in blood and synovium from patients with RA. METHODS:In microarray...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Turrel-Davin F,Tournadre A,Pachot A,Arnaud B,Cazalis MA,Mougin B,Miossec P

    更新日期:2010-04-01 00:00:00

  • Lysosomal activation by neutral saccharides in cell cultures of synovium.

    abstract::On exposure to sucrose or neutral polysaccharides, cell cultures from human synovium showed cytoplasmic vacuolation, increased numbers of lysosomes, and ultrastructural changes simulating those described in rheumatoid synovial intima and similarly treated embryonic caritlage and bone. These changes were accompanied by...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Marshall JL,Fraser JR,Muirden KD

    更新日期:1977-04-01 00:00:00

  • Histological evidence that infliximab treatment leads to downregulation of inflammation and tissue remodelling of the synovial membrane in spondyloarthropathy.

    abstract:OBJECTIVE:To confirm and extend the immunopathological evidence of effects of infliximab on the synovium in active spondyloarthropathy. METHODS:Synovial biopsies obtained in patients with spondyloarthropathy at baseline and week 12 were stained and scored by two independent observers. Two study populations were evalua...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kruithof E,Baeten D,Van den Bosch F,Mielants H,Veys EM,De Keyser F

    更新日期:2005-04-01 00:00:00

  • 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis.

    abstract::This paper presents the second update of the Assessment in SpondyloArthritis international Society (ASAS) consensus statement on the use of anti-tumour necrosis factor (anti-TNF) agents in patients with axial spondyloarthritis (SpA). A major change from the previous recommendations is that patients fulfilling the ASAS...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章


    authors: van der Heijde D,Sieper J,Maksymowych WP,Dougados M,Burgos-Vargas R,Landewé R,Rudwaleit M,Braun J,Assessment of SpondyloArthritis international Society.

    更新日期:2011-06-01 00:00:00

  • The complement system in systemic lupus erythematosus: an update.

    abstract::The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the str...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Leffler J,Bengtsson AA,Blom AM

    更新日期:2014-09-01 00:00:00

  • Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis.

    abstract:BACKGROUND:There is emerging evidence that the development and progression of osteoarthritis (OA) is associated with inflammation. C reactive protein (CRP), a systemic marker for inflammation, may be elevated in OA patients but the evidence is conflicting. OBJECTIVE:To systematically review the literature for the rela...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Jin X,Beguerie JR,Zhang W,Blizzard L,Otahal P,Jones G,Ding C

    更新日期:2015-04-01 00:00:00

  • Efficacy and safety of adalimumab as monotherapy in patients with rheumatoid arthritis for whom previous disease modifying antirheumatic drug treatment has failed.

    abstract:OBJECTIVE:To evaluate the efficacy and safety of monotherapy with adalimumab in patients with RA for whom previous DMARD treatment has failed. METHODS:In a 26 week, double blind, placebo controlled, phase III trial, 544 patients with RA were randomised to monotherapy with adalimumab 20 mg every other week, 20 mg weekl...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: van de Putte LB,Atkins C,Malaise M,Sany J,Russell AS,van Riel PL,Settas L,Bijlsma JW,Todesco S,Dougados M,Nash P,Emery P,Walter N,Kaul M,Fischkoff S,Kupper H

    更新日期:2004-05-01 00:00:00

  • Conventional treatments for ankylosing spondylitis.

    abstract::Management of ankylosing spondylitis (AS) is challenged by the progressive nature of the disease. To date, no intervention is available that alters the underlying mechanism of inflammation in AS. Currently available conventional treatments are palliative at best, and often fail to control symptoms in the long term. Cu...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审


    authors: Dougados M,Dijkmans B,Khan M,Maksymowych W,van der Linden S,Brandt J

    更新日期:2002-12-01 00:00:00

  • Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study.

    abstract:OBJECTIVE:To evaluate the safety, efficacy and therapeutic mechanism of BI 655064, an antagonistic anti-CD40 monoclonal antibody, in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX-IR). METHODS:In total, 67 patients were randomised to receive weekly subcutaneous doses of 120 mg ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Visvanathan S,Daniluk S,Ptaszyński R,Müller-Ladner U,Ramanujam M,Rosenstock B,Eleftheraki AG,Vinisko R,Petříková A,Kellner H,Dokoupilova E,Kwiatkowska B,Alten R,Schwabe C,Baum P,Joseph D,Fine JS,Padula SJ,Steffgen J

    更新日期:2019-06-01 00:00:00

  • Allele *2 of the HS1,2A enhancer of the Ig regulatory region associates with rheumatoid arthritis.

    abstract:OBJECTIVE:To investigate the role of the HS1,2 enhancer polymorphisms as a new candidate marker for rheumatoid arthritis (RA) and to define the possible association with autoantibody positivity and clinical outcome. METHODS:Genomic DNA was obtained from two cohorts of patients with RA (100 with early RA (ERA) and 114 ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Tolusso B,Frezza D,Mattioli C,Fedele AL,Bosello S,Faustini F,Peluso G,Giambra V,Pietrapertosa D,Morelli A,Gremese E,De Santis M,Ferraccioli GF

    更新日期:2009-03-01 00:00:00

  • Listeria monocytogenes infection in a prosthetic knee joint in rheumatoid arthritis.

    abstract::The prosthetic knee joint of a 64 year old woman with severe rheumatoid arthritis was found to be infected with Listeria monocytogenes. After treatment with intravenous antibiotics, symptoms gradually resolved. She subsequently received prolonged treatment with oral co-trimoxazole and 18 months later remained well. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Booth LV,Walters MT,Tuck AC,Luqmani RA,Cawley MI

    更新日期:1990-01-01 00:00:00

  • Studies of the effect of D-penicillamine and sodium aurothiomalate therapy on superoxide anion production by monocytes from patients with rheumatoid arthritis: evidence for in vivo stimulation of monocytes.

    abstract::The capacity of monocytes from patients with rheumatoid arthritis to generate superoxide anion in vitro after stimulation with serum treated zymosan (STZ) or IgG treated zymosan (IgTZ) was studied before and during therapy with penicillamine (n = 9) or sodium aurothiomalate (AuTM) (n = 12). Significant increases in ra...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Hurst NP,Bell AL,Nuki G

    更新日期:1986-01-01 00:00:00

  • Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis.

    abstract:BACKGROUND:Increased subchondral bone turnover may contribute to pain in osteoarthritis (OA). OBJECTIVES:To investigate the analgesic potential of a modified version of osteoprotegerin (osteoprotegerin-Fc (OPG-Fc)) in the monosodium iodoacetate (MIA) model of OA pain. METHODS:Male Sprague Dawley rats (140-260 g) were...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Sagar DR,Ashraf S,Xu L,Burston JJ,Menhinick MR,Poulter CL,Bennett AJ,Walsh DA,Chapman V

    更新日期:2014-08-01 00:00:00

  • Serum osteocalcin concentrations in patients with rheumatoid arthritis.

    abstract::Osteocalcin is a non-collagenous bone matrix protein which is released into the circulation and can be measured by radioimmunoassay. Recent studies indicate that serum osteocalcin concentrations are a marker of bone formation. Because bone demineralisation is a common finding in patients with rheumatoid arthritis (RA)...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Pietschmann P,Machold KP,Wolosczuk W,Smolen JS

    更新日期:1989-08-01 00:00:00

  • HLA antigens in Behçet's disease: a reappraisal by a comparative study of Turkish and British patients.

    abstract::We have compared the distribution of histocompatibility antigens of 22 Turkish and 14 British patients with Behçet's disease with those of their respective controls. There was a strong association of B5, specifically its Bw51 split, with the disease. A modest increase in the incidence of HLA B27 was noted in British p...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Yazici H,Chamberlain MA,Schreuder I,D'Amaro J,Muftuoglu M

    更新日期:1980-08-01 00:00:00

  • Anticardiolipin antibodies: isotype distribution and phospholipid specificity.

    abstract::Quantitative isotype specific enzyme linked immunosorbent assay (ELISA) was used to determine the distribution of immunoglobulin isotypes and phospholipid specificities of anticardiolipin (anti-CL) antibodies in 40 patients with one or more of the following 'antiphospholipid (anti-PL) antibody associated clinical comp...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Gharavi AE,Harris EN,Asherson RA,Hughes GR

    更新日期:1987-01-01 00:00:00

  • Short-term progression of interstitial lung disease in systemic sclerosis predicts long-term survival in two independent clinical trial cohorts.

    abstract:OBJECTIVE:To assess survival and identify predictors of survival in patients with systemic sclerosis-interstitial lung disease (SSc-ILD) who participated in the Scleroderma Lung Studies (SLS) I and II. METHODS:SLS I randomised 158 patients with SSc-ILD to 1  year of oral cyclophosphamide (CYC) vs placebo. SLS II rando...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,随机对照试验


    authors: Volkmann ER,Tashkin DP,Sim M,Li N,Goldmuntz E,Keyes-Elstein L,Pinckney A,Furst DE,Clements PJ,Khanna D,Steen V,Schraufnagel DE,Arami S,Hsu V,Roth MD,Elashoff RM,Sullivan KM,SLS I and SLS II study groups.

    更新日期:2019-01-01 00:00:00

  • Synovitis associated with serum IgM rheumatoid factor arising spontaneously in 'Old English' rabbits.

    abstract::This paper reports the spontaneous development of synovitis in 'Old English' rabbits concurrent with serum IgM rheumatoid factor. Female rabbits developed lesions at a higher incidence than males (42% compared with 17%) and the pathology was of a more severe nature. In the female rabbits synovitis was associated with ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章


    authors: Hanglow AC,Welsh CJ,Conn P,Thomas DS,Coombs RR

    更新日期:1986-04-01 00:00:00