Fibrosis regression induced by intravenous gammaglobulin treatment.

abstract：QUESTION:Which is the best strategy to achieve (drug-free) inactive disease in juvenile idiopathic arthritis (JIA)? METHODS:In a randomised, single-blinded, study in disease-modifying anti-rheumatic drug (DMARD)-naive patients with JIA, three treatment-strategies were compared: (1) sequential DMARD-monotherapy (sulfas...

journal_title：Annals of the rheumatic diseases

authors： Hissink Muller P,Brinkman DMC,Schonenberg-Meinema D,van den Bosch WB,Koopman-Keemink Y,Brederije ICJ,Bekkering PW,Kuijpers TW,Van Rossum M,van Suijlekom-Smit LWA,van den Berg JM,Boehringer S,Allaart CF,Ten Cate R

更新日期：2019-01-01 00:00:00

abstract：:The microfocal x-ray unit, a new type of x-ray machine characterised by an extremely small x-ray source, enables great detail to be recorded in the projection radiographs owing to the high object magnification and resolution obtained with this system. Microfocal radiographic examinations were carried out on the wrists...

journal_title：Annals of the rheumatic diseases

authors： Buckland-Wright JC

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:To determine the influence of TAP1 and TAP2 alleles in northwestern Colombian patients with systemic lupus erythematosus (SLE). METHODS:Unselected patients with SLE (n=140) and controls (n=120) matched for sex, age, and ethnicity were analysed. Clinical manifestations, clinical activity, and severity of dise...

journal_title：Annals of the rheumatic diseases

authors： Correa PA,Molina JF,Pinto LF,Arcos-Burgos M,Herrera M,Anaya JM

更新日期：2003-04-01 00:00:00

abstract：:In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in response to alterations in the environment owing to mechanical injury and inflammation. These processes not only stimulate the production of enzymes that degrade the cartilage matrix but also inhibit repair. With the use of in vitro ...

journal_title：Annals of the rheumatic diseases

authors： Goldring MB,Otero M,Tsuchimochi K,Ijiri K,Li Y

更新日期：2008-12-01 00:00:00

abstract：:Osteocalcin is a non-collagenous bone matrix protein which is released into the circulation and can be measured by radioimmunoassay. Recent studies indicate that serum osteocalcin concentrations are a marker of bone formation. Because bone demineralisation is a common finding in patients with rheumatoid arthritis (RA)...

journal_title：Annals of the rheumatic diseases

authors： Pietschmann P,Machold KP,Wolosczuk W,Smolen JS

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Low serum vitamin D concentrations have been reported in several autoimmune disorders. OBJECTIVE:To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE). METHODS:378 patients from several European and Israeli cohorts were pool...

journal_title：Annals of the rheumatic diseases

authors： Amital H,Szekanecz Z,Szücs G,Dankó K,Nagy E,Csépány T,Kiss E,Rovensky J,Tuchynova A,Kozakova D,Doria A,Corocher N,Agmon-Levin N,Barak V,Orbach H,Zandman-Goddard G,Shoenfeld Y

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that high concentrations of extracellular inorganic pyrophosphate (PPi), which associate with increased cell synthesis and turnover in cartilage, may act as a marker for structural outcome in knee osteoarthritis (OA). METHOD:One hundred and thirty five consecutive patients referred to ...

journal_title：Annals of the rheumatic diseases

authors： Doherty M,Belcher C,Regan M,Jones A,Ledingham J

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVES:To assess the prevalence and patterns of cardiac abnormalities as detected by cardiac magnetic resonance imaging (MRI) in systemic sclerosis (SSc). METHODS:Fifty-two consecutive patients with SSc underwent cardiac MRI to determine morphological, functional, perfusion at rest and delayed enhancement abnormal...

journal_title：Annals of the rheumatic diseases

authors： Hachulla AL,Launay D,Gaxotte V,de Groote P,Lamblin N,Devos P,Hatron PY,Beregi JP,Hachulla E

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:To examine the expression of the natural killer (NK) antigen CD56, and T cell receptor delta chain antigen (TCR delta), expressed on the gamma delta T cell subset, in patients with scleroderma, and to correlate levels of expression with clinical characteristics. METHODS:Peripheral blood mononuclear cells (P...

journal_title：Annals of the rheumatic diseases

authors： Holcombe RF,Baethge BA,Wolf RE,Betzing KW,Stewart RM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of age on the effectiveness and tolerance of antitumour necrosis factor alpha (TNFalpha) therapy in rheumatoid arthritis (RA). METHODS:730 patients of the Dutch Rheumatoid Arthritis Monitoring (DREAM) register were categorised into three groups according to their age at initiatio...

journal_title：Annals of the rheumatic diseases

authors： Radovits BJ,Kievit W,Fransen J,van de Laar MA,Jansen TL,van Riel PL,Laan RF

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVES:To test the hypothesis that PVAC, delipidated, deglycolipidated heat killed Mycobacterium vaccae, is an effective and safe treatment for psoriatic arthritis (PsA). This treatment has shown promising results in psoriasis. METHODS:36 patients with PsA in two centres were studied in this double blind, placebo ...

journal_title：Annals of the rheumatic diseases

authors： Dalbeth N,Yeoman S,Dockerty JL,Highton J,Robinson E,Tan PL,Herman D,McQueen FM

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Ankylosing spondylitis (AS) and periodontal disease (PD) are characterised by dysregulation of the host inflammatory response, resulting in soft and hard connective tissue destruction. AS has been related to other inflammatory diseases, however, there is a paucity of data on whether AS is associated with infl...

journal_title：Annals of the rheumatic diseases

authors： Pischon N,Pischon T,Gülmez E,Kröger J,Purucker P,Kleber BM,Landau H,Jost-Brinkmann PG,Schlattmann P,Zernicke J,Burmester GR,Bernimoulin JP,Buttgereit F,Detert J

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an...

journal_title：Annals of the rheumatic diseases

authors： Möller I,Janta I,Backhaus M,Ohrndorf S,Bong DA,Martinoli C,Filippucci E,Sconfienza LM,Terslev L,Damjanov N,Hammer HB,Sudol-Szopinska I,Grassi W,Balint P,Bruyn GAW,D'Agostino MA,Hollander D,Siddle HJ,Supp G,Schmidt W

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) have an increased risk of certain solid cancers, in particular lung cancer, compared to the general population. Treatment with tumour necrosis factor (TNF) inhibitors (TNFi) may further enhance this risk. OBJECTIVES:To compare the risk of solid cancer in patients with...

journal_title：Annals of the rheumatic diseases

authors： Mercer LK,Lunt M,Low AL,Dixon WG,Watson KD,Symmons DP,Hyrich KL,BSRBR Control Centre Consortium.

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the presence of anti-PDGFR-alpha antibodies by immunological methods in patients with systemic sclerosis (SSc). METHODS:Fifty-eight women diagnosed with SSc and 36 healthy women controls were included. IgG anti-PDGFR-alpha were measured by ELISA and immunoblot. Associations with clinical and immu...

journal_title：Annals of the rheumatic diseases

authors： Balada E,Simeón-Aznar CP,Ordi-Ros J,Rosa-Leyva M,Selva-O'Callaghan A,Pardos-Gea J,Fonollosa-Pla V,Vilardell-Tarrés M

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVE:To study prescription patterns of biological treatment in rheumatoid arthritis (RA) patients in southern Sweden, a region with no formal or economic restrictions for the use of biological treatment in rheumatological diseases. Specifically, we studied conformity with the national Swedish guidelines for biolog...

journal_title：Annals of the rheumatic diseases

authors： Söderlin MK,Geborek P

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS:Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA...

journal_title：Annals of the rheumatic diseases

authors： Glinatsi D,Baker JF,Hetland ML,Hørslev-Petersen K,Ejbjerg BJ,Stengaard-Pedersen K,Junker P,Ellingsen T,Lindegaard HM,Hansen I,Lottenburger T,Møller JM,Ørnbjerg L,Vestergaard A,Jurik AG,Thomsen HS,Torfing T,Møller-Bisgaa

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Antenatal and postnatal treatment with dexamethasone (DEX) may negatively affect the neuropsychological development in children. Maternal anti-Ro/Sjögren's syndrome A (SSA) antibodies may also be associated with learning disabilities in offspring. OBJECTIVE:To assess neuropsychological development in babies...

journal_title：Annals of the rheumatic diseases

authors： Brucato A,Astori MG,Cimaz R,Villa P,Li Destri M,Chimini L,Vaccari R,Muscarà M,Motta M,Tincani A,Neri F,Martinelli S

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:To determine the relationship of disease activity to infections in patients with rheumatoid arthritis (RA). METHODS:From the CORRONA database, the incidence of physician-reported infections in RA patients on stable disease-modifying antirheumatic drug, biological, and corticosteroid therapy for at least 6 mo...

journal_title：Annals of the rheumatic diseases

authors： Au K,Reed G,Curtis JR,Kremer JM,Greenberg JD,Strand V,Furst DE,CORRONA Investigators.

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To investigate the first-ever incidence of acute myocardial infarction and stroke in a community based RA cohort compared with the general population. METHODS:The RA cohort consisted of all patients in a local RA register in Malmö, Sweden (n = 1022). The patients were recruited from private and hospital base...

journal_title：Annals of the rheumatic diseases

authors： Turesson C,Jarenros A,Jacobsson L

更新日期：2004-08-01 00:00:00

abstract：OBJECTIVE:To determine whether a multimodal physiotherapy programme including taping, exercises, and massage is effective for knee osteoarthritis, and if benefits can be maintained with self management. METHODS:Randomised, double blind, placebo controlled trial; 140 community volunteers with knee osteoarthritis partic...

journal_title：Annals of the rheumatic diseases

authors： Bennell KL,Hinman RS,Metcalf BR,Buchbinder R,McConnell J,McColl G,Green S,Crossley KM

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:To compare the risk of keratinoctye skin cancer (basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)) in patients treated for rheumatoid arthritis (RA) compared with the general population, and to determine whether anti-tumour necrosis factor (TNF) therapy exacerbates this risk. METHODS:Patients wi...

journal_title：Annals of the rheumatic diseases

authors： Mercer LK,Green AC,Galloway JB,Davies R,Lunt M,Dixon WG,Watson KD,British Society for Rheumatology Biologics Register Control Centre Consortium.,Symmons DP,Hyrich KL,British Society for Rheumatology Biologics Register.

更新日期：2012-06-01 00:00:00

abstract：:A 46 year old man presented with a growing mass over his wrist. Erosions of the triquetrum and hamate were present radiographically. Magnetic resonance imaging (MRI) showed a solid mass arising from the extensor carpi ulnaris tendon, which was T(1) hypointense and isointense, T(2) hypointense, and bloomed on gradient ...

journal_title：Annals of the rheumatic diseases

authors： Peh WC,Shek TW,Ip WY

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:In an unselected community sample of adults, to assess the role and importance of exposure to mechanical factors both at work and leisure in the aetiology of hip pain. METHOD:A population based prevalence case-control study. Cases and controls were identified from a population survey of 3847 subjects registe...

journal_title：Annals of the rheumatic diseases

authors： Pope DP,Hunt IM,Birrell FN,Silman AJ,Macfarlane GJ

更新日期：2003-04-01 00:00:00

abstract：:Circulating immune complexes (CIC) were measured in 4 normal controls and 8 patients with systemic lupus erythematosus (SLE) by a polyethylene glycol precipitation (PEG) method during a 24-hour period. In all the normal controls levels fell during sleep and after drinking 1 pint (568 ml) of milk and rose before gettin...

journal_title：Annals of the rheumatic diseases

authors： Isenberg DA,Crisp AJ,Morrow WJ,Newham D,Snaith ML

更新日期：1981-10-01 00:00:00

abstract：OBJECTIVE:To define the mechanisms whereby methotrexate (MTX) manifests its effects in patients with rheumatoid arthritis. METHODS:T and B cells from peripheral blood and rheumatoid synovial tissues, synovial adherent cells, and the human fibrosarcoma cell line HT1080 and its mutant (defective in an enzyme in the nucl...

journal_title：Annals of the rheumatic diseases

authors： Nakajima A,Hakoda M,Yamanaka H,Kamatani N,Kashiwazaki S

更新日期：1996-04-01 00:00:00

abstract：:Monoclonal antibodies have proved to be extremely valuable additions to conventional treatment for rheumatic diseases. However, despite the general trend towards "humanisation", these drugs remain immunogenic in clinical settings, baffling drug developers. In principle, humanised and fully human monoclonal antibodies ...

journal_title：Annals of the rheumatic diseases

authors： Scott DW,De Groot AS

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Immunogenicity of aTNFs is one of the mechanisms behind treatment failure. OBJECTIVE:To assess the effect of anti-drug antibodies (ADA) on drug response to infliximab, adalimumab and etanercept, and the effect of immunosuppression on ADA detection, in patients with Rheumatoid Arthritis, Spondyloarthritis, P...

journal_title：Annals of the rheumatic diseases

authors： Garcês S,Demengeot J,Benito-Garcia E

更新日期：2013-12-01 00:00:00

abstract：OBJECTIVES:In salivary glands from patients with Sjögren syndrome, overexpression of laminins 1 and 5 and disorganisation of the acinar basal lamina have been reported. Laminin 5 mediates association of the basal lamina with epithelial cells by forming adhesion complexes upon interaction with alpha6beta4 integrin. In t...

journal_title：Annals of the rheumatic diseases

authors： Velozo J,Aguilera S,Alliende C,Ewert P,Molina C,Pérez P,Leyton L,Quest A,Brito M,González S,Leyton C,Hermoso M,Romo R,González MJ

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:While various monocyte chemokine systems are increased in expression in osteoarthritis (OA), the hierarchy of chemokines and chemokine receptors in mediating monocyte/macrophage recruitment to the OA joint remains poorly defined. Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/C...

journal_title：Annals of the rheumatic diseases

authors： Raghu H,Lepus CM,Wang Q,Wong HH,Lingampalli N,Oliviero F,Punzi L,Giori NJ,Goodman SB,Chu CR,Sokolove JB,Robinson WH

更新日期：2017-05-01 00:00:00