Natural killer cells and gamma delta T cells in scleroderma: relationship to disease duration and anti-Scl-70 antibodies.

abstract：:During 1978 a survey was carried out on 34 036 people in Nagano Prefecture, Japan, in an epidemiological study of hyperuricaemia; 15 713 males and 18 324 females were examined by means of our health examination car. The subjects of the survey were all volunteers. The results have shown that the serum uric acid (SUA) l...

journal_title：Annals of the rheumatic diseases

authors： Akizuki S

更新日期：1982-06-01 00:00:00

abstract：:Two patients with sickle cell disease presented with joint pain and early x-ray evidence of articular cartilage loss. Both later developed increasingly destructive arthritis with chronic synovitis identified in synovial biopsies. One patient developed demonstrable aseptic necrosis. Destructive arthropathy is much less...

journal_title：Annals of the rheumatic diseases

authors： Schumacher HR,Dorwart BB,Bond J,Alavi A,Miller W

更新日期：1977-10-01 00:00:00

abstract：:Fifteen consecutive patients with acute arthritis were studied. Careful culture and microscopy of swabs from mucosal sites were performed to examine the hypothesis that the acute tropical polyarthritis commonly seen in Zimbabwe is due to undiagnosed gonococcal infection. Rheumatic fever and Reiter's disease accounted ...

journal_title：Annals of the rheumatic diseases

authors： Stein CM,Hanly MG

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Anti-tumour necrosis factor (TNF) treatment is clinically efficacious in patients with active ankylosing spondylitis (AS) and leads to improvement of spinal inflammation, as assessed by magnetic resonance imaging. It is unclear whether anti-TNF treatment affects chronic spinal changes in AS. OBJECTIVES:To a...

journal_title：Annals of the rheumatic diseases

authors： Baraliakos X,Listing J,Rudwaleit M,Brandt J,Sieper J,Braun J

更新日期：2005-10-01 00:00:00

abstract：:Three patients presented with septal fasciitis and panniculitis, associated with clinical and laboratory features which precluded straight-forward classification into eosinophilic fasciitis, localised scleroderma, or lupus erythematosus profundus. Treatment with cimetidine caused the remission of cutaneous manifestati...

journal_title：Annals of the rheumatic diseases

authors： Naschitz JE,Yeshurun D,Rosner I,Abrahamson JE,Misselevitch I,Boss JH

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Interferon (IFN) beta displays anti-inflammatory and immunosuppressive activity and has been considered for the treatment of rheumatoid arthritis (RA). Information about the effects of this molecule on joint cells is scarce, however. OBJECTIVE:To investigate the effects of IFNbeta on the production of inter...

journal_title：Annals of the rheumatic diseases

authors： Palmer G,Mezin F,Juge-Aubry CE,Plater-Zyberk C,Gabay C,Guerne PA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Medical management of adults with osteoarthritis (OA) who require non-steroidal anti-inflammatory drugs (NSAIDs) must be decided after assessing prevalent gastrointestinal (GI) and cardiovascular (CV) risks in the individual patient. OBJECTIVE:To evaluate the GI and CV risk profile of patients with OA who r...

journal_title：Annals of the rheumatic diseases

authors： Lanas A,Tornero J,Zamorano JL

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with unknown aetiology. Epstein-Barr virus (EBV) is an environmental factor associated with SLE. EBV maintains latency in B cells with frequent reactivation measured by antibodies against viral capsid antigen (VCA) and early antigen (EA). In ...

journal_title：Annals of the rheumatic diseases

authors： Jog NR,Young KA,Munroe ME,Harmon MT,Guthridge JM,Kelly JA,Kamen DL,Gilkeson GS,Weisman MH,Karp DR,Gaffney PM,Harley JB,Wallace DJ,Norris JM,James JA

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Fractalkine expressed on endothelial cells mediates activation and adhesion of leucocytes expressing its receptor, CX(3)CR1. Soluble fractalkine exhibits chemotactic activity for leucocytes expressing CX(3)CR1. OBJECTIVE:To determine the role of fractalkine and its receptor in systemic sclerosis (SSc) by as...

journal_title：Annals of the rheumatic diseases

authors： Hasegawa M,Sato S,Echigo T,Hamaguchi Y,Yasui M,Takehara K

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early,...

journal_title：Annals of the rheumatic diseases

authors： Gohar F,McArdle A,Jones M,Callan N,Hernandez B,Kessel C,Miranda-Garcia M,Lavric M,Holzinger D,Pretzer C,Lainka E,Vastert SJ,de Roock S,FitzGerald O,Pennington SR,Foell D

更新日期：2019-08-01 00:00:00

abstract：:A nutritional assessment of 50 patients with rheumatoid arthritis (RA) showed evidence of malnutrition in 13 (26%), while all 50 control subjects had normal nutritional status. Of the anthropometric measurements the body-mass index and triceps skinfold thickness values in men and women were significantly reduced in RA...

journal_title：Annals of the rheumatic diseases

authors： Helliwell M,Coombes EJ,Moody BJ,Batstone GF,Robertson JC

更新日期：1984-06-01 00:00:00

abstract：:Leucopenia appears to be a more frequent complication of sulphasalazine treatment in rheumatoid arthritis than in inflammatory bowel disease and poses a management problem. In this study leucopenia was found in 20 patients, 14 of whom were participating in prospective studies (252 patients), giving an incidence of 5.6...

journal_title：Annals of the rheumatic diseases

authors： Marabani M,Madhok R,Capell HA,Hunter JA

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:There is emerging evidence that the development and progression of osteoarthritis (OA) is associated with inflammation. C reactive protein (CRP), a systemic marker for inflammation, may be elevated in OA patients but the evidence is conflicting. OBJECTIVE:To systematically review the literature for the rela...

journal_title：Annals of the rheumatic diseases

authors： Jin X,Beguerie JR,Zhang W,Blizzard L,Otahal P,Jones G,Ding C

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:To elucidate the differential role of peptidyl arginine deiminase 4 (PADI4) polymorphism in rheumatoid arthritis (RA) between Asian and European populations, possible gene-environmental interactions among the PADI4 polymorphism, sex and smoking status were analysed. METHODS:Three independent sets of case-con...

journal_title：Annals of the rheumatic diseases

authors： Kochi Y,Thabet MM,Suzuki A,Okada Y,Daha NA,Toes RE,Huizinga TW,Myouzen K,Kubo M,Yamada R,Nakamura Y,Yamamoto K

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To examine the association between body mass index (BMI) and osteoarthritis (OA) leading to total hip (THR) or knee (TKR) joint replacement. METHODS:Case-control study design. All patients still living in Iceland who had had a THR or TKR resulting from OA before the end of 2002 were invited to participate. F...

journal_title：Annals of the rheumatic diseases

authors： Franklin J,Ingvarsson T,Englund M,Lohmander LS

更新日期：2009-04-01 00:00:00

abstract：:The aim of this report was to propose a definition for erosive disease in the context of inflammatory arthritis in light of the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria for use in clinical practice and studies. A EULAR task force was form...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde D,van der Helm-van Mil AH,Aletaha D,Bingham CO,Burmester GR,Dougados M,Emery P,Felson D,Knevel R,Kvien TK,Landewé RB,Lukas C,McInnes I,Silman AJ,Smolen JS,Stanislawska-Biernat E,Zink A,Combe B

更新日期：2013-04-01 00:00:00

abstract：:Platelet serotonin concentrations were measured in 43 patients with systemic sclerosis, in 11 patients with primary Raynaud's phenomenon, and in 38 normal controls. Patients with the CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) had significantly lower platele...

journal_title：Annals of the rheumatic diseases

authors： Klimiuk PS,Grennan A,Weinkove C,Jayson MI

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:To report the efficacy of conservative treatment with cervical traction and immobilisation with a Halo vest, in two consecutive rheumatoid arthritis patients with progressive cervical myelopathy caused by subaxial subluxation. METHODS:Description of neurological symptoms and signs and findings in plain radio...

journal_title：Annals of the rheumatic diseases

authors： Oostveen JC,van de Laar MA,Geelen JA,de Graaff R

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Qualitative differences in synovitis between the cartilage-pannus junction (CPJ) region and the adjoining suprapatellar pouch (SPP) have been reported in rheumatoid arthritis and the spondyloarthropathies. OBJECTIVE:To determine if the distribution of synovitis is the same in osteoarthritis (OA) using sensi...

journal_title：Annals of the rheumatic diseases

authors： Rhodes LA,Conaghan PG,Radjenovic A,Grainger AJ,Emery P,McGonagle D

更新日期：2005-09-01 00:00:00

abstract：:One hundred acute geriatric inpatients were assessed to investigate the prevalence of shoulder disorders; 21 had symptoms due to shoulder disease. Conditions included supraspinatus tendinitis (five), chronic rotator cuff rupture (seven), frozen shoulder (two), glenohumeral osteoarthritis (two), apatite related shoulde...

journal_title：Annals of the rheumatic diseases

authors： Chard MD,Hazleman BL

更新日期：1987-09-01 00:00:00

abstract：:Plasma DNA has been measured by a new physiochemical approach based on fluorimetric analysis of phenol extracted nucleic acids electrophoresed on polyacrylamide gels. This method is specific for native double-stranded DNA of molecular weight greater than 5 x 10(6). The use of plasma rigorously freed of leucocytes is e...

journal_title：Annals of the rheumatic diseases

authors： Klemp P,Meyers OL,Harley EH

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND:Reaching the therapeutic target of remission or low-disease activity has improved outcomes in patients with rheumatoid arthritis (RA) significantly. The treat-to-target recommendations, formulated in 2010, have provided a basis for implementation of a strategic approach towards this therapeutic goal in routi...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Breedveld FC,Burmester GR,Bykerk V,Dougados M,Emery P,Kvien TK,Navarro-Compán MV,Oliver S,Schoels M,Scholte-Voshaar M,Stamm T,Stoffer M,Takeuchi T,Aletaha D,Andreu JL,Aringer M,Bergman M,Betteridge N,Bijls

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Several studies suggest a role of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in the pathophysiology of primary osteoarthritis (OA). A common polymorphism of the GH receptor (exon 3 deletion, d3-GHR) is associated with increased GH/IGF-1 activity. OBJECTIVE:To study associations betwee...

journal_title：Annals of the rheumatic diseases

authors： Claessen KM,Kloppenburg M,Kroon HM,Bijsterbosch J,Pereira AM,Romijn JA,van der Straaten T,Nelissen RG,Hofman A,Uitterlinden AG,Duijnisveld BJ,Lakenberg N,Beekman M,van Meurs JB,Slagboom PE,Biermasz NR,Meulenbelt I

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVES:Little data are available regarding the rate and predicting factors of serious infections in patients with rheumatoid arthritis (RA) treated with abatacept (ABA) in daily practice. We therefore addressed this issue using real-life data from the Orencia and Rheumatoid Arthritis (ORA) registry. METHODS:ORA is...

journal_title：Annals of the rheumatic diseases

authors： Salmon JH,Gottenberg JE,Ravaud P,Cantagrel A,Combe B,Flipo RM,Schaeverbeke T,Houvenagel E,Gaudin P,Loeuille D,Rist S,Dougados M,Sibilia J,Le Loët X,Meyer O,Solau-Gervais E,Marcelli C,Bardin T,Pane I,Baron G,Perrod

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (PSORS1C1, TNIP1 and RHOB) as novel genetic risk factors for the disease. The aim of this study was to replicate the previously mentioned findings in a large multicentre independent SSc cohort of Cauc...

journal_title：Annals of the rheumatic diseases

authors： Bossini-Castillo L,Martin JE,Broen J,Simeon CP,Beretta L,Gorlova OY,Vonk MC,Ortego-Centeno N,Espinosa G,Carreira P,García de la Peña P,Oreiro N,Román-Ivorra JA,Castillo MJ,González-Gay MA,Sáez-Comet L,Castellví I,Schuer

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to analyse retrospectively adult patients with acute joint or muscle symptoms and a high antistreptolysin O (ASO) titre to find out which syndromes of clinical arthritis are associated with serological evidence of streptococcal infection. METHODS:Seventy six adult patients with...

journal_title：Annals of the rheumatic diseases

authors： Valtonen JM,Koskimies S,Miettinen A,Valtonen VV

更新日期：1993-07-01 00:00:00

abstract：:No consensus has previously been formed regarding the types and presentations of infectious pathogens to be considered as 'opportunistic infections' (OIs) within the setting of biologic therapy. We systematically reviewed published literature reporting OIs in the setting of biologic therapy for inflammatory diseases. ...

journal_title：Annals of the rheumatic diseases

authors： Winthrop KL,Novosad SA,Baddley JW,Calabrese L,Chiller T,Polgreen P,Bartalesi F,Lipman M,Mariette X,Lortholary O,Weinblatt ME,Saag M,Smolen J

更新日期：2015-12-01 00:00:00

abstract：:A novel, constitutively expressed and secreted interleukin 18 (IL18) binding protein (IL18BP) neutralises IL18. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited a...

journal_title：Annals of the rheumatic diseases

authors： Dinarello CA

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS:A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission rec...

journal_title：Annals of the rheumatic diseases

authors： Liu B,Balkwill A,Cooper C,Roddam A,Brown A,Beral V,Million Women Study Collaborators.

更新日期：2009-07-01 00:00:00

abstract：:Three hundred and twenty-one synovial fluids from the knees of patients with six different inflammatory arthropathies have been examined for the presence of cytophagocytic monocytes (CPM) and mast cells. Both cell types were seen independently in many of the fluids examined but were found together only in those patien...

journal_title：Annals of the rheumatic diseases

authors： Freemont AJ,Denton J

更新日期：1985-05-01 00:00:00