Up regulated expression of fractalkine/CX3CL1 and CX3CR1 in patients with systemic sclerosis.

abstract：OBJECTIVES:To determine concentrations of chondroitin sulphate (CS) and keratan sulphate (KS) epitopes, glycosaminoglycans (GAGs) and hyaluronan (HA) in knee synovial fluid (SF) from normal subjects and patients with osteoarthritis (OA) or rheumatoid arthritis (RA), to test whether these variables may be used as marker...

journal_title：Annals of the rheumatic diseases

authors： Belcher C,Yaqub R,Fawthrop F,Bayliss M,Doherty M

更新日期：1997-05-01 00:00:00

abstract：:Persistent infectious polyarthritis caused by Ureaplasma urealyticum in a patient with common variable hypogammaglobulinaemia is described. The patient developed a symmetrical, destructive polyarthritis and tenosynovitis associated with a markedly depressed synovial fluid glucose concentration and characteristic soft ...

journal_title：Annals of the rheumatic diseases

authors： Lehmer RR,Andrews BS,Robertson JA,Stanbridge EJ,de la Maza L,Friou GJ

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:Hyperplasia of synovial fibroblasts, infiltration with lymphocytes and tissue hypoxia are major characteristics of rheumatoid arthritis (RA). Extensive data support a key role for toll-like receptors (TLRs) in RA. Little is known regarding the impact of hypoxia on TLR-induced inflammation in RA. The aim of t...

journal_title：Annals of the rheumatic diseases

authors： Hu F,Mu R,Zhu J,Shi L,Li Y,Liu X,Shao W,Li G,Li M,Su Y,Cohen PL,Qiu X,Li Z

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To compare ultrasound measurement of median nerve cross-sectional area (CSA) at different anatomical landmarks and to assess the value of power Doppler signals within the median nerve for diagnosis of carpal tunnel syndrome (CTS). METHODS:A prospective study of 135 consecutive patients with suspected CTS und...

journal_title：Annals of the rheumatic diseases

authors： Dejaco C,Stradner M,Zauner D,Seel W,Simmet NE,Klammer A,Heitzer P,Brickmann K,Gretler J,Fürst-Moazedi FC,Thonhofer R,Husic R,Hermann J,Graninger WB,Quasthoff S

更新日期：2013-12-01 00:00:00

abstract：:Sepsis is a severe complication of abdominal infections such as peritonitis and is associated with high mortality. Unfortunately, the molecular mechanisms controlling the development of sepsis are still incompletely understood. Interestingly, the interleukin (IL) 12 family member IL27 seems to play a key role in sepsi...

journal_title：Annals of the rheumatic diseases

authors： Neurath MF

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To analyse tender and swollen joint counts in three cohorts of patients with rheumatoid arthritis (RA), with a focus on the proportions of patients who had fewer than 6-12 tender or swollen joints, as possible evidence based information toward more generalisable inclusion criteria for current and future RA cl...

journal_title：Annals of the rheumatic diseases

authors： Pincus T,Sokka T,Chung CP,Cawkwell G

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVE:To propose e-learning methods that address the fundamental problems related to sonographic training in rheumatology. METHODS:The project was designed for rheumatologists with strong motivation to learn ultrasound. A modular approach was constructed, consisting of a basic 3-day residential course, followed by...

journal_title：Annals of the rheumatic diseases

authors： Filippucci E,Meenagh G,Ciapetti A,Iagnocco A,Taggart A,Grassi W

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA). OBJECTIVE:/st> To develop recommendations for achieving optimal therapeutic outcomes in RA. METHODS:A task force of rheuma...

journal_title：Annals of the rheumatic diseases

authors： Smolen JS,Aletaha D,Bijlsma JW,Breedveld FC,Boumpas D,Burmester G,Combe B,Cutolo M,de Wit M,Dougados M,Emery P,Gibofsky A,Gomez-Reino JJ,Haraoui B,Kalden J,Keystone EC,Kvien TK,McInnes I,Martin-Mola E,Montecucco C,

更新日期：2010-04-01 00:00:00

abstract：OBJECTIVES:To characterise renal tissue metabolic pathway gene expression in different forms of glomerulonephritis. METHODS:Patients with nephrotic syndrome (NS), antineutrophil cytoplasmic antibody-associated vasculitis (AAV), systemic lupus erythematosus (SLE) and healthy living donors (LD) were studied. Clinically ...

journal_title：Annals of the rheumatic diseases

authors： Grayson PC,Eddy S,Taroni JN,Lightfoot YL,Mariani L,Parikh H,Lindenmeyer MT,Ju W,Greene CS,Godfrey B,Cohen CD,Krischer J,Kretzler M,Merkel PA,Vasculitis Clinical Research Consortium, the European Renal cDNA Bank cohort, and th

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Despite the importance of timely management of patients with inflammatory arthritis (IA), delays exist in its diagnosis and treatment. OBJECTIVE:To perform a systematic literature review to identify strategies addressing these delays to inform an American College of Rheumatology (ACR)/European League Agains...

journal_title：Annals of the rheumatic diseases

authors： Villeneuve E,Nam JL,Bell MJ,Deighton CM,Felson DT,Hazes JM,McInnes IB,Silman AJ,Solomon DH,Thompson AE,White PH,Bykerk VP,Emery P

更新日期：2013-01-01 00:00:00

abstract：:The effect of transforming growth factor beta (TGF beta) on proteoglycan synthesis and degradation in anatomically intact articular cartilage of murine patellae was studied. Exogenously added TGF beta up to a concentration of 200 pmol/l had no effect on proteoglycan synthesis in intact articular cartilage. Neutralisat...

journal_title：Annals of the rheumatic diseases

authors： van der Kraan PM,Vitters EL,van den Berg WB

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVES:The humoral immune response against a broad spectrum of cartilage antigens (cellular and matrix antigens) was studied in a group of patients who showed resorption and/or rejection of transplanted cartilage in nasal surgery. METHODS:Sera were obtained from patients with successful and unsuccessful cartilage ...

journal_title：Annals of the rheumatic diseases

authors： Bujia J,Alsalameh S,Naumann A,Wilmes E,Sittinger M,Burmester GR

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To investigate the incidence of new cancer diagnoses in a community sample of patients with polymyalgia rheumatica (PMR). METHODS:All incident cases of PMR in the UK General Practice Research Database (GPRD) (1987-99), without pre-existing cancer or vascular disease and treated with corticosteroids (n=2877) ...

journal_title：Annals of the rheumatic diseases

authors： Muller S,Hider SL,Belcher J,Helliwell T,Mallen CD

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:To clarify the deleterious effects of Mayer's haematoxylin staining procedure which result in a decrease in, or complete loss of, the number of calcium pyrophosphate dihydrate (CPPD) crystals, and to determine the proper staining period for preserving the crystals in a histological paraffin section of articul...

journal_title：Annals of the rheumatic diseases

authors： Ohira T,Ishikawa K

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Individuals with psoriasis have increased blood levels of uric acid. However, there is no prospective data on the association between psoriasis and uric acid levels and subsequent development of gout. In this study, we examined the risk of gout among individuals with psoriasis and psoriatic art...

journal_title：Annals of the rheumatic diseases

authors： Merola JF,Wu S,Han J,Choi HK,Qureshi AA

更新日期：2015-08-01 00:00:00

abstract：:Alefacept is a bioengineered fusion protein of soluble lymphocyte function antigen (LFA-3) with Fc fragments of IgG1. It is marketed in many countries for the treatment of moderate to severe psoriasis. This paper reviews the data supporting the use of alefacept in psoriasis and psoriatic arthritis. ...

journal_title：Annals of the rheumatic diseases

authors： Gottlieb AB

更新日期：2005-11-01 00:00:00

abstract：:There is no agreement as to which variable best mirrors disease activity in rheumatoid arthritis (RA) and no studies have been performed on the validity of disease activity variables. In this study the validity of 10 commonly used single variables and three composite indices was tested. All patients participated in a ...

journal_title：Annals of the rheumatic diseases

authors： van der Heijde DM,van't Hof MA,van Riel PL,van Leeuwen MA,van Rijswijk MH,van de Putte LB

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:To present and analyse the literature sources regarding the management of Behçet disease (BD) identified during the systematic literature research, which formed the basis for the European League Against Rheumatism (EULAR) evidence-based recommendations for the management of BD. METHODS:Problem areas and rel...

journal_title：Annals of the rheumatic diseases

authors： Hatemi G,Silman A,Bang D,Bodaghi B,Chamberlain AM,Gul A,Houman MH,Kötter I,Olivieri I,Salvarani C,Sfikakis PP,Siva A,Stanford MR,Stübiger N,Yurdakul S,Yazici H

更新日期：2009-10-01 00:00:00

abstract：:A novel explanation for the natural history of joint destruction in the early phase of ankylosing spondylitis is proposed on the basis of the clinical history, x-ray appearance, operative findings, and histopathology of a young patient believed to be suffering from the peripheral form of this disease. ...

journal_title：Annals of the rheumatic diseases

authors： Pasion EG,Goodfellow JW

更新日期：1975-02-01 00:00:00

abstract：OBJECTIVE:To explore the safety, efficacy, and lymphocyte activation of a triple therapeutic regimen with infliximab, methotrexate (MTX), and ciclosporin A (CsA) by an open label, pilot study. PATIENTS AND METHODS:19 patients (mean age 52.9 years) with active rheumatoid arthritis (mean DAS28 7.3) after a mean of 16.8 ...

journal_title：Annals of the rheumatic diseases

authors： Sidiropoulos PI,Siakka P,Raptopoulou A,Mamoulaki M,Choulaki C,Koutala H,Kouroumali H,Kritikos H,Boumpas DT

更新日期：2006-04-01 00:00:00

abstract：:Two patients with sickle cell disease presented with joint pain and early x-ray evidence of articular cartilage loss. Both later developed increasingly destructive arthritis with chronic synovitis identified in synovial biopsies. One patient developed demonstrable aseptic necrosis. Destructive arthropathy is much less...

journal_title：Annals of the rheumatic diseases

authors： Schumacher HR,Dorwart BB,Bond J,Alavi A,Miller W

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:An association between major histocompatibility complex (MHC) genes, particularly those within the class II HLA region, and rheumatoid arthritis (RA) is well established, and accounts for an estimated 30% of the genetic component in RA. The MHC class II transactivator gene (MHC2TA) on chromosome 16p13 has re...

journal_title：Annals of the rheumatic diseases

authors： Bronson PG,Criswell LA,Barcellos LF

更新日期：2008-07-01 00:00:00

abstract：:The effect of two gold(I) compounds on stability of lysosomes in vitro was studied. Lysosomes from homogenates of rat kidney cortex were isolated by differential centrifugation. These lysosomes were incubated at 37 degrees C with widely varied concentrations of sodium aurothiomalate and sodium aurothiosulphate for 5, ...

journal_title：Annals of the rheumatic diseases

authors： Graabaek PM,Pedersen SM

更新日期：1988-06-01 00:00:00

abstract：OBJECTIVES:Increased numbers of neutrophils expressing proteinase 3 on their membrane (mPR3) have been reported in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and are suggested to be involved in AAV immunopathogenesis. In most studies, neutrophils were analysed for mPR3 expression without prim...

journal_title：Annals of the rheumatic diseases

authors： van Rossum AP,Huitema MG,Stegeman CA,Bijl M,de Leeuw K,Van Leeuwen MA,Limburg PC,Kallenberg CG

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase (MMP)1, interleukin(IL)6 and vitamin D receptor (VDR) have been implicated in the biological cascade of events initiated by particulate wear debris and bacterial infection, resulting in periprosthetic bone loss around loosened total hip replacements (THRs). The individual responses t...

journal_title：Annals of the rheumatic diseases

authors： Malik MH,Jury F,Bayat A,Ollier WE,Kay PR

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:To assess the impact of certolizumab pegol (CZP) on patient-reported outcomes (PROs) in rheumatoid arthritis (RA), and to interpret these results using number needed to treat (NNT), and associations between PRO responses and longer term outcomes. METHODS:A total of 619 patients with active RA were randomised...

journal_title：Annals of the rheumatic diseases

authors： Strand V,Smolen JS,van Vollenhoven RF,Mease P,Burmester GR,Hiepe F,Khanna D,Nikaï E,Coteur G,Schiff M

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVES:To develop evidence-based EULAR recommendations for cardiovascular (CV) risk management in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA). METHODS:A multidisciplinary expert committee was convened as a task force of the EULAR Standing Committee for Clinica...

journal_title：Annals of the rheumatic diseases

authors： Peters MJ,Symmons DP,McCarey D,Dijkmans BA,Nicola P,Kvien TK,McInnes IB,Haentzschel H,Gonzalez-Gay MA,Provan S,Semb A,Sidiropoulos P,Kitas G,Smulders YM,Soubrier M,Szekanecz Z,Sattar N,Nurmohamed MT

更新日期：2010-02-01 00:00:00

abstract：:Volatile short-chain fatty acids (SCFA) in synovial fluid from 80 patients were quantified by gas-liquid chromatography (GLC). Characteristic patterns of volatile SCFA could not be associated with septic, nonseptic inflammatory, or noninflammatory groups. Mean concentrations of pentanoic and hexanoic acids were simila...

journal_title：Annals of the rheumatic diseases

authors： Borenstein DG,Gibbs CA,Jacobs RP

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVES:Examine whether osteoarthritis (OA) progression can be delayed by halofuginone in anterior cruciate ligament transection (ACLT) rodent models. METHODS:3-month-old male C57BL/6J (wild type; WT) mice and Lewis rats were randomised to sham-operated, ACLT-operated, treated with vehicle, or ACLT-operated, treate...

journal_title：Annals of the rheumatic diseases

authors： Cui Z,Crane J,Xie H,Jin X,Zhen G,Li C,Xie L,Wang L,Bian Q,Qiu T,Wan M,Xie M,Ding S,Yu B,Cao X

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:To define the relationship between autoantigen citrullination and different peptidylarginine deiminase (PAD) enzymes in rheumatoid arthritis (RA). METHODS:Citrullinated autoantigens were identified by immunoblotting control and ionomycin-activated human primary neutrophil lysate with RA sera. Autoantigen ide...

journal_title：Annals of the rheumatic diseases

authors： Darrah E,Rosen A,Giles JT,Andrade F

更新日期：2012-01-01 00:00:00